Obese cat SDL

Question 1

What is the physiologic principle behind weight gain in hyperadrenocorticism?

Answer 1

Increased cortisol (opposes action of insulin) => increased insulin secretion => increased storage of glucose as fat

Question 2

What is the physiologic principle behind weight gain in hypothyroidism

Answer 2

Lack of thyroid hormone - determines the basic metabolic rate and the rate at which calories are used

Question 3

What is the physiologic principle behind weight gain in acromegaly

Answer 3

Excess GH = short term antagonist of insulin
Promotes bone, cartilage and soft tissue growth
Not related to fat deposition so does not cause obesity

Question 4

How does obesity cause insulin resistance?

Answer 4

Chronic hyperglycaemia -> downregulation of insulin receptors, impaired receptor binding affinity for insulin, affects post-receptor insulin action intracellularly