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BECOM Exam 1 > Nucleic Acids > Flashcards

Nucleic Acids Flashcards

1
Q

what is PRPP used in?

A
  • de novo synthesis of purine/pyrimidines
  • salvage of purine/pyrimidines
  • synthesis of NAD from tryptophan
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2
Q

NAD is from which amino acid?

A

tryptophan

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3
Q

where on PRPP does building start?

A

C1 (anomeric carbon)

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4
Q

where does the ribose 5- phosphate used to make PRPP come from?

A

pentose phosphate pathway

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5
Q

what is the rate determining step of purine synthesis?

A

PRPP to 5-phosphoribosyl 1-amine

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6
Q

what enzyme is involved in the rate determining step of purine synthesis?

A

glutamine phosphoribosyl amidotransferase

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7
Q

what activates the rate determining step of purine synthesis?

A

PRPP

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8
Q

what other things are involved in the rate determining step of purine synthesis?

A
  • glutamine

- H2O

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9
Q

what enzyme does allopurinol inhibit?

A

xanthine oxidase

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10
Q

Gout management

A
  • NSAIDS
  • Dietary changes
  • Colchicine
  • Probenicid
  • Allopurinol
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11
Q

symptoms of Lesch-Nyhan Syndrome

A

HGPRT

H- Hyperuricemia
G- Gout
P- Pissed off (aggressive/self mutilation)
R- Retardation
T- dysTonia (spasticity)
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12
Q

what is the first step in pyrimidine biosynthesis?

A

formation of carbamoyl phosphate

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13
Q

what inhibits CPS II?

A

UTP

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14
Q

what activates CPS II?

A

PRPP

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15
Q

what is the nitrogen source for CPS II?

A

glutamine

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16
Q

what is the nitrogen source for CPS I?

A

ammonia

17
Q

CPS II location

A

cytosol

18
Q

CPS I location

A

mitochondria

19
Q

how many ATP does CPS II use?

A

2 ATP

20
Q

what is the order of enzymes for forming UMP from aspartate and carbamoyl phosphate?

A

1- Aspartate trans carbamoylase
2- Dihydroorotase, Dihydroorotate dehydrogenase
3- Orotate phosphoribosyl transferase
4- Orotate monophosphate decarboxylase

21
Q

deficiency in what enzyme(s) causes increase in orotic acid

A
  • orotate phosphorybosyl transferase

- OMP decarboxylase

22
Q

what enzyme does 6-mercaptopurine eventually act on?

A

inhibits amido transferase

23
Q

what enzyme does 5-flurouracil eventually act on?

A

inhibits thymidylate synthase (irreversibly)

BECOM Exam 1 (13 decks)

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