NT Flashcards
dopamine hypothesis
based on the idea that patients with SZ have excess dopamine in their brains
explained by amphetamines- dopamine agonists - increase level of dop in brain
when taken in large quantities experince similar symotoms to SZ positive symptoms such as hallucinations and dellusions
A03.1 strength
lindstrom et al used PET scans to trace L- DOPA chemical used by brain produce dopamine
administered L-DOPA to 10 untreated patients with SZ and a control without SZ .
L-DOPA taken up more quicklu in SZ patients
suggesting producing more dopamine then control group - supports dopamine hypothesis
A03.1 weakness
BOWERS suggested HVA major metabolite of dopamine was not found in greater quantities with SZ patients
A01.2 glutamate and dopamine
glutamate binds to NMDA receotors
dop and glutamate work as a break and accelorator causing SZ increased glut decreased dop and vise versa
low glut in cerebra cortex - negative symtoms
perception, thought, language, and decision-making, integrating sensory- poverty of speech and difficulty following sentances.
low glutamate in basal ganglia + posititve symptoms
voluntary motor control, motor learning, and routine behaviors or habits.
- repetitive behaviours
A03.2 strength
carlson found PCP can incuce a psychotic conditon mimicking SZ more failthfully than amphetamines
antagonist of NMDA glutamte deficiency-r role in psychosis
carlsson and carlsson found NMDA antagonist- lowers glutamate caused mice to move forward with no intention
A03.2 weakness
laxks gen - animsals less developed PFC problem solving not able to see most symtoms
decrease cred
A03.2 strength2-
wong et al post morten studies brains with DZ DA receptirs are hypersensitive and in great nuumber
too many receptors is similar to having too much dopamine as have greater opp for dopamine to stimulate receport and cause over activity and + symtpms
A03.2 weakness2
ignores brain structure…. explain
suddath- MRI MZ twins could tell 12/15
A01.3
increased levels of DA in mesolimbic areas of brain cause positive symptoms
reward, pleasure, and reinforcement of behaviors.
positive symptoms like hallucinations and delusions by amplifying abnormal reward and perception processing.
low DA in mesocorital area- negative
cognitive functions, such as decision-making, attention, and emotional regulation.
such as lack of motivation, flattened affect, and cognitive difficulties.
seritonin
associated with mood regulation, body temp and sleep
balences dopamine levels in mesolimbic pathway so low levels lead to + symptoms
A03.3 strength
antipsychotics reduce + symtpoms by blocking DA recepotors to prevent over activiity demonstrating that excess dop role in SZ
A03.3 weakness
ignores role of enviro, triggger for SZ freeman or vassos sweeden, denmark, netherlands 2,37X more likely in urban than in rural
conclusion
suggests SZ NT imbalence treatment == anti psycs block dop - improve qual life
stress diatheisis