Non-Hormonal Regulators

Question 1

Suppresses activity of osteoclasts
Inhibits bone resorption and bone formation
FOR PAGET’S DISEASE OF BONE, HYPERCALCEMIA, OSTEOPOROSIS, BONE METS
SE: Adynamic bone, ESOPHAGITIS (ESOPHAGEAL ULCERS), OSTEONECROSIS OF JAW, renal impairment
Take with large quantities of water and avoid situations that permit esophageal reflux
CI IN PATIENTS WITH RENAL IMPAIRMENT, ESOPHAGEAL MOTILITY DISORDERS AND PEPTIC ULCERS

Answer 1

Alendronate

Etidronate, Ibandronate, Pamidronate, Risedronate, Tiludronate, Zoledronic Acid

Question 2

Phosphate binding resin
For HYPERPHOSPHATEMIA IN CKD
can significantly reduce uric acid levels
CI IN HYPOPHOSPHATEMIA AND
BOWEL OBSTRUCTION

Answer 2

Sevelamer