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Pharmacology > Adrenergic Pharmacology > Flashcards

Adrenergic Pharmacology Flashcards

1
Q

primary NT at sympathetic post-ganglionic neuron-effector cell synapses

A

Norepinephrine

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2
Q

EXCEPTIONS

A
  1. eccrine sweat glands

2. vasodilator sympathetic fibers

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3
Q

VasoDILATORY

A

Dopamine

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4
Q

VasoCONSTRICTIVE

A

Norepinephrine

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5
Q

Inhibits rate-limiting step in NE synthesis

inhibits tyrosine hydroxylation to DOPA

A

Metyrosine

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6
Q

vesicular transport of NE and Dopa inhibited…

A

Reserpine

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7
Q

transport of NE and Dopa into vesicles inactivated by…

A

monoamine oxidase

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8
Q

increase stores of NE and Dopa

A

MAOIs

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9
Q

inhibit entry of Ca, which triggers interaction among SNARE proteins

A

Guanethidine

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10
Q

promoted entry of Ca

A

Amphetamines and Tyramine (can also increase tryptophan)

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11
Q

diffusion and reuptake via NET and DAT in synaptic cleft inhibited by…

A

Cocaine and TCAs

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12
Q

metabolisation by MAO and COMT into metanephrines and VMA inhibited by…

A

MAOIs and COMT inhibitors (capone)

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Pharmacology (31 decks)

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