Antipsychotics

Question 1

typical antipsychotic
blocks D2 receptors
SE: failure of ejaculation, marked sedation, CORNEAL & LENS DEPOSITS, neuroleptic malignant syndrome, contact dermatitis, decreased seizure threshold

Answer 1

chlorpromazine
thiothexene
brand name: thorazene

Question 2

typical antipsychotic
blocks D2 receptors
for anti-emesis
SE: failure of ejaculation, retinal deposits, cardiotoxicity (QT prolongation - arrythmias in prototype)
STRONGEST AUTONOMIC EFFECTS
ONLY ANTIPSYCHOTIC WITH FATAL OVERDOSE

Answer 2

thioridazine

fluphenazine, perphenazine, prochlorperazine, trifluoroperazine

Question 3

typical antipsychotic
blocks D2 receptors
SE: EPS, NEUROLEPTIC MALGINANT SYNDROME
WEAKEST AUTONOMIC EFFECTS
LEAST SEDATING among typical antipsychotics

Answer 3

haloperidol

droperidol

Question 4

atypical antipsychotic
blocks 5-HT receptors
for REFRACTORY, SUICIDAL schizophrenia
SE: weight gain, hyperglycemia, hyperlipidemia, myocarditis, AGRANULOCYTOSIS, seizures, ileus, hypersalivation (sialorrhea)
REDUCES RISK OF SUICIDE

Answer 4

clozapine

if ANC < 1500, stop clozapine

Question 5

atypical antipsychotic
blocks 5-HT receptors
SE: weight gain, hyperglycemia, hyperlipidemia

Answer 5

olanzapine

Question 6

atypical antipsychotic
blocks 5-HT receptors
SE: somnolence, fatigue, sleep paralysis, hypnagogic hallucinations, CATARACTS, PRIAPISM

Answer 6

quetiapine

Question 7

atypical antipsychotic
blocks 5-HT receptors
SE: hyperprolactinemia (marked), photosensitivity
only antipsychotic approved for SCHIZOPHRENIA IN THE YOUNG

Answer 7

risperidone

Question 8

atypical antipsychotic
blocks 5-HT receptors
SE: postural hypotension, QT PROLONGATION (TORSADES)
LITTLE OR NO TENDENCY TO CAUSE HYPERGLYCEMIA, HYPERPROLACTINEMIA, WEIGHT GAIN
increased mortality in elderly patients with dementia-related psychosis
with some histamine and alpha blockade

Answer 8

ziprasidone

Question 9

atypical antipsychotic
blocks 5-HT receptors
LEAST SEDATING among atypical antipsychotics
NO ATROPINE-LIKE EFFECTS
LITTLE OR NO TENDENCY TO CAUSE HYPERGLYCEMIA, HYPERPROLACTINEMIA, OR WEIGHT GAIN

Answer 9

aripiprazole

Question 10

features of neuroleptic malignant syndrome

Answer 10

FEVER

Fever
Encephalopathy
Vitals unstable
elevated CPK
Rigidity