NME 2.17 Flashcards
what happens when concentration of calcium is low?
- there is absorption by active transport
what happens when concentration of calcium is high?
- absorbed through passive diffusion
what carrier protein does calcium bind to?
- bind to carrier protein
- intestinal membrane calcium binding protein
what protein does calcium bind to inside the cell?
- calcium binding protein
what stimulates the absorption of calcium?
- derivative of vitamin D3
- parathyroid hormone
which two mechanisms help with keeping cell concentration for calcium to be low?
- sodium/calcium exchanger at basolateral border
- primary active transport carried out by calcium-ATPase
how does bile salts indirectly facilitate absorption of calcium?
- promotion formation of micelles
what causes secretory diarrhoea?
- ion transport defect which cause over secretion and motility disturbances
which type of diarrhoea does food poisoning cause?
- secretory diarrhoea
how does bacteria of food poisoning cause diarrhoea?
- produce toxins binding to secreting crypts cells to increase intracellular cAMP
- stimulate massive secretion
- excessive activation of intrinsic neuron cause secretory diarrhoea
how is secretory diarrhoea characterised?
- continuation with fasting
- high electrolyte concentration in stools
how is osmotic diarrhoea characterised?
- cessation with fasting
- acidic and hyperosmotic stools
what cause osmotic diarrhoea?
- mal-absorption
- high concentration of salts
- cause water to be transported to lumen