Nicotine

Question 1

Absorption of nicotine if swallowed.

Answer 1

Weak base: Absorption in the INTESTINE if swallowed.

Question 2

half-life

Answer 2

2hours

Question 3

Metabolised by

Answer 3

CYP2A6

Question 4

Pharmacodynamic of nicotine

Answer 4

Nicotinic acetylcholine Receptor (nAChRs)

Question 5

Classic agonist of mAChRs

Answer 5

MUSCARINE

Question 6

Classic agonist of nAChRs

Answer 6

Nicotine

Question 7

nAChR-nicotinic cholinergic receptor is (witch type of receptor)

Answer 7

Classic Ion channel

Question 8

mAChR-muscarinic cholinergic receptor is (witch type of receptor)

Answer 8

G-protein couple receptor

Question 9

Structure of nAChRs

Answer 9

PENTAMERIC: 5 subunits

4 domains

Question 10

For the activation of the receptor nAChRs we need

Answer 10

2x alpha4 and 3x beta2

TWO BINDING SITES for stimultaneous binding (between each a2 and b2)

Question 11

The defect of CYP2A6 decrease carcinogenicity and a smaller risk of comorbidity from cigarette-related to:

Answer 11

CYP2A6 is resposible to activate procarcinogen into carcinogen and convert nicotine into cotinine (nicotine’s metabolite)

Question 12

nAChRs can be blocked by:

Answer 12

Curare

Question 13

mAChRs can be blocked by:

Answer 13

Atropine

Question 14

alpha 7 is a (type of channel)

Answer 14

Calcium channel ONLY.

Question 15

alpha 4 beta 2 is (type of channel)

Answer 15

Mainly sodium channel (but also calcium channel)