CNS stimulant

Question 1

2 major effect of COCAINE (pharmacodynamics)

Answer 1

Block the reuptake of transmitters

Blocking the voltage-gated sodium channels on the axons.

Question 2

Blocking Voltage-gated sodium channels is effective in the PERIPHERY

Answer 2

block transmission of pain into nerve fibers

block feeling of temperature, pressure, touch…

Question 3

High dose of cocaine effect

Answer 3

Convulsion
Respiratory arrest
Block SA node (pacemaker) or His-Purkinje system (cardiac arrrest)

Question 4

Effect of Cocaine in the Neurotransmitter/sodium symporter (NSS)

Answer 4

block the reuptake of the three major amines (Dopamine, norepinephrine & serotonin)

Question 5

Dopaminergic receptor are (witch type of receptor)

Answer 5

Classic GPCRs

Question 6

Toxic metabilite when take cocaine and alcohol

Answer 6

Cocaethylene

Question 7

Cocaine is Metabolize by

Answer 7

Majority by Human carboxylesterase 1 enzymes

and some by CYP450s

Question 8

Normal esterification of cocaine by the enzyme will produce

Answer 8

Benzoylecgonine

Question 9

Addiction altering glutamate receptor

Answer 9

AMPA receptor for glutamate by change numbers and types of glutaminergic receptor and new receptors appear during withdrawal

Question 10

Amphetamine pharmacodynamic effect

Answer 10

Increase release of dopamine & noradrenaline
Blocking reuptake
Increase breakdown of amines

Question 11

Methamphetamine is

Answer 11

amphetamine derivatives, smokable form name ICE

Question 12

Methamphetamine damage..

Answer 12

Dopaminergic neurons –> risk of Parkinson disease

Question 13

MDMA (ecstasy) is

Answer 13

ampetamine derivatives, stimulant and hallucinogenic effect

Question 14

MDMA affect (pharmacodynamic)

Answer 14

Block serotonin transporter

Affect 5HT, dopaminergic and noradrenalinergic pathways

Question 15

Harbal ecstasy is

Answer 15

Ephedrine DANGEROUS

Question 16

Chronic use MDMA

Answer 16

loss of 5HT transporters (permanent loss od nerve endings)

Question 17

Caffeine act on (pharmacodynamic)

Answer 17

Adenosine receptors (Competitive antagonist)

Question 18

Adenosine is a

Answer 18

neuromodulator that inhibits release of various transmitter

Question 19

Caffeine role in the A1 receptor

Answer 19

Block the inhibitor receptor (adenosine receptor activity) result in increased activity in the cholinergic networks.