Drugs Interactions

Question 1

Effect of drug A is greater in the presence of drug B:

Answer 1

Potentiation

Question 2

Total effect is equal to effect of drug A plus effect of drug B:

Answer 2

Additive

Question 3

Total effect is greater than the effect of drug A plus effect of drug B:

Answer 3

Synergistic

Question 4

Effect of drug A is weaker in the presence of drug B

Answer 4

Antagonistic

Question 5

Why L-DOPA is giving with Carbidopa?

Answer 5

Beneficial interaction: Allow most of the L-DOPA to cross the BBB and be metabolized into Dopamine (DA).
Need lower dose of L-DOPA and reduce peripheral side-effects.

Question 6

Carbidopa:

Answer 6

DOPA-Decarboxylase inhibitor

Cannot cross the BBB

Question 7

DOPA-Decarboxylase inhibitor is:

Answer 7

Inhibit DDC, inhibit the formation of DA in the peripheral.

Question 8

In the Dosage-Response Curves,

Pharmacodynamics interaction moves the curves…

Answer 8

up or down.

Question 9

In the Dosage-Response Curves,

Pharmacokinetics interaction moves the curves…

Answer 9

right to left.

Question 10

Ibuprofen should be avoid when we take: rx___

Because:__

Answer 10

Aspirin bc it inhibit the anti-platelet effect

Question 11

Respiratory failure due to combination of opioid and CNS depressants is an example of (type de interaction).

Answer 11

Synergetic interaction

Question 12

St-John’s Wort induce (enzyme).

Answer 12

CYP3A4

Question 13

Using SJW in the same time of Statins or immunosupressant cause:

Answer 13

decrease of efficacy.

Question 14

Antibiotics and anti-fungal agent inhibit (enzyme)

Answer 14

CYP3A4

Question 15

Taking antibiotics or anti-fungal agent with Statins cause:

Answer 15

Increase accumulation and risk of toxic effect. (stay longer in the circulation)

Question 16

What happen when oral contraceptives interact with antimicrobial agents?

Answer 16

Antimocrobial agents decrease the serum estradiol level (by altering the GI flora, which disrupts the Enterohepatic cycle of estradiol)

Question 17

Pharmacokinetics interaction mechanisms: (it alter..)

Answer 17

• Alter the PLASMA level

- moving the curve dose-response from left to right

Question 18

Calcium Carbonate interaction with Synthroid:

Answer 18

Inhibit Absorption of Synthroid.

Question 19

Tetracycline interact with Milk/ anti-acid:

Answer 19

Decrease/inhibit the absorption or Tetracycline.

Question 20

p-Glycoprotein is found in:

Answer 20

BBB, intestinal epithelium, renal and liver.

Question 21

Ethanol induce (enzyme):

Answer 21

CYP2E1

Question 22

Smoking induce (enzyme):

Answer 22

CYP1A2

Question 23

St-john wort increase the effect of:

Answer 23

Plavix

Question 24

Grapefruit contain:

Answer 24

Naringen

Question 25

Grapefruit inhibit the metabolism of:

Answer 25

Statin and coffee..

Question 26

P-Glycoproteins function:

Answer 26

efflux pump transporting xenobiotic (toxic, anti-cancer drugs,..) compounds out the cell.