NFS284 Chapter 3 Flashcards
Path of nutrients in the body
- Digestion
- Absorption
- Metabolism in cells
- Eliminate waste
4 major types of tissue
- Muscle
- Nerve
- Epithelial
- Connective
Tissues play a role in the…
Digestion stage of food
2 types of tissue found in the stomach
- nervous
- connective
Purpose of tissue in the stomach
signals brain when stomach is empty or full
Purpose of muscles in the stomach
Begin digestion process by churing ingested food
Purpose of specialized epithelial cells in the stomach
Produce acids and enzymes that help break down the food (faster)
Digestion
Break down food chemically and mechanically into parts that are small enough to be absorbed by the body
Absorption
Taking substances obtained from food into the interior of the body
The digestive system is broken down into 2 steps.
- Digestion
2. Absorption
Food can be broken down in 2 ways
- Chemically
2. Mechanically
What does the GI tract include?
- mouth
- pharynx
- esophagus
- stomach
- small intestines
- large intestines
- anus
What are the accessory organs that aid the digestive process?
- salivary glands
- liver
- pancreas
- gallbladder
Function of:
mouth
chew food, mix food with saliva
Function of:
salivary glands
produce saliva (contains amylase which break down starch)
Function of:
pharynx
swallows chewed food + saliva
Function of:
esophagus
moves food into stomach
Function of:
liver
makes bile
Function of:
bile
helps digestion & absorption of fat
Function of:
pancreas
- Secretes bicarbonate to neutralize intestinal contents
- Produce enzymes that break down carbs, proteins, fats
Function of:
gallbladder
stores bile, and release it into small intestines when needed
Function of:
small intestines
- Finishes digestion process
- Absorption of nutrients into blood / lymph
Function of:
large intestines
- Absorbs water, vitamins, minerals
- Intestinal bacteria
- Passes waste
The large intestines consist of…
- Colon
- Rectum
Function of:
anus
opens to allow waste to leave body
Transit time
Time it takes for food to pass through the GI tract
How long is transit time typically?
24 - 72 h
What impacts transit time?
- Food that is being digested
- Fibres
How is transit time measured?
A dye that can’t be absorbed by the body is added to the meal
How long does it take for dye to appear in poop?
What type of food passes through GI tract without absorption taking place?
Indigestible food
Which nutrient influences transit time?
Dietary fibre
What is the gut wall made up of?
- small intestine = layer of tissue
- lumen
- mucosa / mucosal cells / epithelial cells
Anatomy of the gut wall
(out -> in)
- connective tissue
- smooth muscle
- connective tissue
- mucosa
- lumen
Mucosa
layer of tissue lining the lumen in the GI tract
Function of mucosal cells
- absorb nutrients
- secrete mucus
2 things secreted by the digestive system
- digestive enzymes
2. mucus
What is gastric motility?
More gastric juices secreted
More muscle activity
Amylase
Breaks down starch -> sugars
Where is salivary amylase found?
mouth
What causes increased gastric motility?
Senses food -> brain -> tells stomach to increase gastric motility
Where is rennin found?
stomach
Distension
Stretching
Where is trypsin found?
pancreas
What does stretching of the stomach stimulate?
send signals to brain
brain: release gastrin
gastrin: increase gastric secretions and motility
Where is carboxypeptidase, aminopeptidase, and dipeptidase found?
small intestines
What does gastrin do?
Increase gastric secretions (HCl), which is needed to convert pepsinogen to pepsin.
Also increases motility
Function of salivary amylase
break starch -> smaller carbohydrate molecules
What are 2 ways to increase gastric secretion & motility?
- Brain
2. Gastrin
Function of rennin
Curdles milk protein casein
Hormones in the intestines do what?
Decrease gastric secretion & motility
Casein
A milk protein
Where is the pyloric valve?
Between stomach & small intestines
Function of pepsin
Proteins & polypeptides -> AA
How long does it take for food to go through the stomach?
2-6 h
Function of trypsin
proteins & polypeptides -> shorter polypeptides
The small intestines is the major site for…
Digestion & absorption
Function of chymotrypsin
proteins & polypeptides -> shorter polypeptides
What are 3 ways in which the small intestines increase SA?
- Large folds
- Villi
- Microvilli
Function of lipase
monoglycerides -> FA & glycerol
Villi are well supported by…
- Bld vessels (oxygen, nutrients)
- Lacteal
Function of carboxypeptidase
polypeptides -> AA
How are dietary fats removed from the digestive tract?
Through lacteal -> lymphatic system
Function of pancreatic lipase
triglyceride -> monoglycerides & FA & glycerol
___ cells are on the surface of the villi
mucosal
Function of pancreatic amylase
starch -> shorter glucose chains & maltose
Nutrients pass from lumen through ___ to enter ___ or ____. This is then transported to the rest of the body.
Mucosal cells
Blood stream
Lympth
Function of carboxypeptidase, aminopeptidase, dipeptidase
Polypeptides -> AA
Another name for microvilli
brush border
Which 3 enzymes found in the small intestine tend to be grouped together?
carboxypeptidase
aminopeptidase
dipeptidase
Where are microvilli located?
On the mucosal cells that face the lumen in the small intestines
Function of sucrase
sucrose -> glucose & fructose
Enterocytes
mucosal cells with microvilli
Mucosal cells with microvilli on them are called…
enterocytes
Function of lactase
lactose -> glucose & galactose
What is secreted from the pancreas?
- bicarb
2. digestive enzymes (amylases, proteases, lipases)
Function of maltase
maltose -> glucose
Which proteases are secreted by the pancreas?
- trypsin
- chymotrypsin
Function of dextrinase
short chains of glucose -> individual glucose
Why are bicarb ions secreted by the pancreas?
Neutralize the HCl entering the small intestines along with the chyme
Location of pepsin
stomach
location of chymotrypsin
pancreas
Lipases are used for the digestion of…
triglycerides
Location of carboxypeptidase
pancreas
Which accessory organ in the digestive system can we live without?
Gall bladder
Location of lipase
small intestines
What is the purpose of the gall bladder?
Store bile
Location of sucrase
small intestines
What is the purpose of bile?
- Emulsify fats
- Break fat into smaller droplets & keep them stabilized to be absorbed (digestive tract is polar)
Location of lactase
small intestines
Small intestines secrete…
- intestinal juices
2. brush border enzymes
Purpose of intestinal juice
substance containing water & mucus.
Mix chyme with digestive juices
Location of maltase
small intestines
Location of dextrinase
small intestines
Purpose of brush border enzymes
Break down polypeptides -> AA
Digest carbohydrates
The digestive tract is made up of ____. Without mucus, it would be digested by the enzymes.
Proteins
Which 2 hormones are released when food enters the small intestine?
- secretin
2. CCK
Enzymes protect cells from…
Autodigestion
Secretin stimulates secretion of…
- Bile: liver -> gall bladder
2. Bicarb from pancreas
Mucus is secreted by
Mucous membranes (which are made up of epithelial cells)
CCK stimulates the release of…
- Bile: gall bladder -> intestines
2. Digestive enzymes from pancreas
Cells in the mucosa layer is [long / short] lived. Why?
Short.
Mucosa cells have high nutrient requirements (one of the first to be affected by nutrient deficiencies)
What is the valve that separates small and large intestine?
ileocecal valve
Intestinal cells need…
High levels of nutrients
What enters the large intestine?
Food not absorbed in the small intestine
What are some parts of the body that is first affected by nutrient deficiency?
- Intestinal cells
- Cells of the immune system
What are reabsorbed in the small intestine?
- water
- micronutrients (continued from small intestines)
What regulates the function of the digestive system?
Nerve signals between brain GI tract
How long does food spend in the small intestines?
3-4h
Where can nerve signals be found in the digestive system?
Between GI tract and brain.
Between different parts of the GI tract.
How long does food spend in the large intestines?
24h
What are the 5 hormones of the digestive system?
- gastrin
- somatostatin
- secretin
- CCK
- Gastric inhibitory peptide
What happens to materials not absorbed in the colon?
excreted as feces
CCK
cholecystokinin