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Zak, Heme/Lymph > Neutropenic Fever Pharmacology > Flashcards

Neutropenic Fever Pharmacology Flashcards

1
Q

Most common microbes from indwelling catheters

A

S. Aureus
S. Epidermidis
Klebsiella

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2
Q

Most common fungi

A

Candida*

Aspergillus

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3
Q

Which ABX are used in 1˚ prophylaxis

A

Fluoroquinolones (Levofloxacin, Ciprofloxacin)

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4
Q

Which Antifungal is used in 1˚ prophylaxis

A

Fluconazole

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5
Q

Which Antifungals are used as alternative Tx for 1˚ prophylaxis

A

Echinocandins (Caspofungin, Micafungin, Anidulafungin)

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6
Q

What ABX is used as 2˚ prophylaxis against Aspergillus

A

Voriconazole

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7
Q

What type of drugs can Voriconazole not be given with

A

Chemo drugs (Cytarabine, Fludarabine, Vincristine)

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8
Q

What are the IV ABX used in empiric Tx

A

Piperacillin + Tazobactam
Carbapenems (-enem)
Ceftazidime, Cefepime

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9
Q

If the pt has cellulitis or pneumonia, what ABX would be used as empiric Tx

A

Vancomycin or Linezolid

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10
Q

If the pt has Gram negative bacteremia, what ABX would be used as empiric Tx

A

Add Gentamicin

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11
Q

If the pt is suspected of having C. Diff, what ABX would be used as empiric Tx

A

Metronidazole

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12
Q

What is the standard PO ABX given for outpatient Tx

A

Ciprofloxacin + Amoxicillin/Clavulanic acid

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13
Q

If the fever persists for > 5 days, which Antifungal is added to the Tx

A

Caspofungin

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14
Q

What drug is given to increase the production of neutrophils and decrease the length of stay in the hospital

A

Filgrastim (G-CSF)

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Zak, Heme/Lymph (15 decks)

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