Hubbard - AML, ALL, CML, CLL, HCL Flashcards
Sx’s = poorly differentiated myeloid precursors in the BM and circulation in pts > 60 yo
Acute Myeloid Leukemia/Lymphoma
Sx’s = increased production of lymphoblasts (thymic cells) in children
Acute Lymphoid Leukemia/Lymphoma
Sx’s = Increased proliferation of granulocyte and megakaryocyte progenitor cells in older men
Chronic Myelogenous Leukemia/Lymphoma
Sx’s = Abnormal proliferation of mature B-cells in pts > 60 yo
Chronic Lymphoid Leukemia/Lymphoma
Which cancers can progress to AML
CML
MDS
MPS
AML’s that have gingival hypertrophy
M4 and M5
Sx’s = cutaneous manifestations of AML showing myeloblasts in the dermis
Sweet’s syndrome
What is the LDH level in AML, CML, ALL
Elevated
What is the Tx for APL
All-trans retinoic acid
Arsenic compounds
What is the AlkPhos level in CML
Low AlkPhos
CML can transform to…
AML or ALL
What is the first line Tx for CML
Imatinib
Sx’s = testicular enlargement and bone pain
ALL
Which mutation has a favorable prognosis in ALL
HOX11
What is the Tx for CNS prophylaxis in ALL
Methotrexate
Which trisomy is most common in CLL
Trisomy 12
CLL can transform to…
DLBCL (Richter Syndrome)
Positive staining for which markers indicates a worse prognosis in CLL
CD38
ZAP-70
What are the stage classifications for CLL
Stage 0 = Lymphocytosis only Stage 1 = + lymphadenopathy Stage 2 = + HSM Stage 3 = + anemia Stage 4 = + thrombocytopenia
Sx’s = pancytopenia w/ splenomegaly and increased reticulin fibers in BM d/t tumors of small lymphocytes w/ oval nuclei
Hairy Cell Leukemia
What markers will stain + in HCL and are specific to that cancer
CD22, 25, 103
TRAP
