Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Zak, Heme/Lymph > Hubbard - AML, ALL, CML, CLL, HCL > Flashcards

Hubbard - AML, ALL, CML, CLL, HCL Flashcards

1
Q

Sx’s = poorly differentiated myeloid precursors in the BM and circulation in pts > 60 yo

A

Acute Myeloid Leukemia/Lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Sx’s = increased production of lymphoblasts (thymic cells) in children

A

Acute Lymphoid Leukemia/Lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Sx’s = Increased proliferation of granulocyte and megakaryocyte progenitor cells in older men

A

Chronic Myelogenous Leukemia/Lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Sx’s = Abnormal proliferation of mature B-cells in pts > 60 yo

A

Chronic Lymphoid Leukemia/Lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which cancers can progress to AML

A

CML
MDS
MPS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

AML’s that have gingival hypertrophy

A

M4 and M5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Sx’s = cutaneous manifestations of AML showing myeloblasts in the dermis

A

Sweet’s syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the LDH level in AML, CML, ALL

A

Elevated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the Tx for APL

A

All-trans retinoic acid

Arsenic compounds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the AlkPhos level in CML

A

Low AlkPhos

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

CML can transform to…

A

AML or ALL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the first line Tx for CML

A

Imatinib

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Sx’s = testicular enlargement and bone pain

A

ALL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which mutation has a favorable prognosis in ALL

A

HOX11

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the Tx for CNS prophylaxis in ALL

A

Methotrexate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which trisomy is most common in CLL

A

Trisomy 12

17
Q

CLL can transform to…

A

DLBCL (Richter Syndrome)

18
Q

Positive staining for which markers indicates a worse prognosis in CLL

A

CD38

ZAP-70

19
Q

What are the stage classifications for CLL

A 
Stage 0 = Lymphocytosis only
Stage 1 = + lymphadenopathy
Stage 2 = + HSM
Stage 3 = + anemia
Stage 4 = + thrombocytopenia
20
Q

Sx’s = pancytopenia w/ splenomegaly and increased reticulin fibers in BM d/t tumors of small lymphocytes w/ oval nuclei

A

Hairy Cell Leukemia

21
Q

What markers will stain + in HCL and are specific to that cancer

A

CD22, 25, 103

TRAP

Zak, Heme/Lymph (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions