Hubbard - Hypercoagulable State

Question 1

Sx’s = recurrent DVT and PE

Answer 1

Deficiency of AT-III

Question 2

What is the Tx for Protein C and S deficiencies

Answer 2

Warfarin

Question 3

Sx’s = unabated thrombosis d/t inherited mutation

Answer 3

Factor V Leiden

Question 4

What is the Tx for Factor V Leiden

Answer 4

aSx Hx = observation

Sx Hx = anticoagulation

Question 5

Heparin inhibits which part of the coagulation cascade

Answer 5

Intrinsic

Question 6

Warfarin/Coumadin inhibits which part of the coagulation cascade

Answer 6

Extrinsic

Question 7

Sx’s = increased activity of prothrombin w/ inability to deactivate creating a very high risk of thrombosis

Answer 7

Prothrombin 20210

Question 8

Sx’s = circulating Abs causing increased clotting

Answer 8

Antiphospholipid Ab Syndrome

Question 9

What 3 things are needed to make the Dx of Antiphospholipid Ab Syndrome

Answer 9

Prolonged PTT
Lack of correction w/ mixing study
Neutralization of inhibitor w/ excess phospholipid

Question 10

What test is more specific than the PTT for Antiphospholipid Ab Syndrome

Answer 10

DRVVT

Question 11

What is the Tx for Antiphospholipid Ab Syndrome

Answer 11

aSx Hx = observation
Sx Hx = anticoagulation
Preggo = Heparin

Question 12

What does tPA do?

Answer 12

Activates plasmin mediating clot lysis via fibrin degradation