Hubbard - Bleeding Disorders

Question 1

Which drugs commonly cause thrombocytopenia

Answer 1

Chemo
Thiazides
Ethanol
Estrogen
Quinine

Question 2

Sx’s = fever, microangiopathic hemolytic anemia, thrombocytopenia, and neuro dysfunction

Answer 2

TTP

Question 3

Sx’s = fever, microangiopathic hemolytic anemia, thrombocytopenia, neuro dysfunction, and renal dysfunction

Answer 3

HUS

Question 4

Sx’s = hyaline thrombi that occlude capillaries

Answer 4

TTP

Question 5

What mutations are seen in Essential Thrombocytosis

Answer 5

JAK2
MPL
CALR

Question 6

What is the Tx for Essential Thrombocytosis

Answer 6

ASA

Question 7

What drugs can cause disordered platelet function leading to prolonged bleeding w/ normal platelet count

Answer 7

ASA, NSAIDs
Clopidogrel
Heparin

Question 8

In Bernard-Soulier, vWF, and Glanzmann syndromes, what is the rxn to Ristocetin and the other tests

Answer 8

Bernard-Soulier, vWF = no aggregation w/ Ristocetin, yes to others
Glanzmann = yes aggregation w/ Ristocetin, no to others

Question 9

Thinning of the vessel walls d/t AD inheritance of CD105 (Endoglin) mutation

Answer 9

Hereditary Hemorrhagic Telangiectasia

Question 10

Sx’s = petechiae around the mouth, epistaxis

Answer 10

Hereditary Hemorrhagic Telangiectasia

Question 11

What is the Tx for Hereditary Hemorrhagic Telangiectasia

Answer 11

Surgery/Photoablation

Question 12

What is the Tx for chronic ITP

Answer 12

Prednisone

Question 13

What is the Tx for TTP

Answer 13

Plasmapheresis

Question 14

What is the Tx for vWF

Answer 14

Desmopressin

Question 15

What is the Tx for liver disease causing thrombocytopenia

Answer 15

FFP