Mutations/Stains

Question 1

Mutation/Translocation for B-ALL

Answer 1

t(12;21): t(9;22), t(1;19), t(4;11)

Question 2

Stains for B-ALL

Answer 2

CD10, 19, 20, PAX5

Question 3

Mutation/Translocation for T-ALL

Answer 3

NOTCH1, BCL6

Question 4

Stains for T-ALL

Answer 4

CD1, 2, 3, 5, 7, 8

Question 5

All ALL’s will stain + for

Answer 5

TdT, PAS

Question 6

Mutation/Translocation for Follicular Lymphoma

Answer 6

t(14;18) - BCL2 MLL2

Question 7

Stains for Follicular Lymphoma

Answer 7

CD10,19,20,BCL2 ~BCL6

Question 8

Mutation/Translocation for DLBCL

Answer 8

BCL6

Question 9

Virus associated w/ Immunodeficient CBCL

Answer 9

EBV

Question 10

Virus associated w/ 1˚ Pleural Effusion type of DLBCL

Answer 10

HHV8

Question 11

Stains for DLBCL

Answer 11

CD19, 20, BCL6 ~BCL2, ~CD10

Question 12

Mutation/Translocation for Burkitt Lymphoma

Answer 12

t(8;14) - MYC

Question 13

Stains for Burkitt Lymphoma

Answer 13

CD10, 19, 20, BCL6, Ki-67

Question 14

Mutation/Translocation for Mantle Cell Lymphoma

Answer 14

t(11;14) - Cyclin D1

Question 15

Stains for Mantle Cell Lymphoma

Answer 15

CD5, 19, 20

Question 16

Mutation/Translocation for Marginal Zone Lymphoma

Answer 16

t(11;18) t(14;18) t(1;14)

Question 17

Stains for Marginal Zone Lymphoma

Answer 17

BCL10, MALT1, BCL2?

Question 18

Stains for HL - Classic Types

Answer 18

CD15, 30

Question 19

Stains for HL - Lymphocyte Predominant Type

Answer 19

CD 19, 20, BCL6

Question 20

Mutation/Translocation for Multiple Myeloma

Answer 20

Cyclin D1 = good 13q, 17p, t(4;14) = bad

Question 21

Stains for Multiple Myeloma

Answer 21

CD56, 138

Question 22

Mutation/Translocation for Waldenstrom’s Macroglobulinemia (Lymphoplasmacytic Lymphoma)

Answer 22

MYD88

Question 23

Stains for Waldenstrom’s Macroglobulinemia (Lymphoplasmacytic Lymphoma)

Answer 23

CD19, 20, 22, PAS

Question 24

Mutation/Translocation for Hairy Cell Leukemia

Answer 24

BRAF

Question 25

Stains for Hairy Cell Leukemia

Answer 25

CD19, 20, 25, 11c, 103 TRAP, Annexin A1

Question 26

Mutation/Translocation for Anaplastic Large Cell Lymphoma

Answer 26

ALK t(2;5)

Question 27

Stains for Anaplastic Large Cell Lymphoma

Answer 27

CD30

Question 28

Stains for Mycosis/Sezary

Answer 28

CLA, CCR4, CCR10

Question 29

Mutation/Translocation for Large Granular Lymphocytic Leukemia

Answer 29

STAT3

Question 30

Stains for Large Granular Lymphocytic Leukemia

Answer 30

T-cell = CD3 NK-cell = CD56

Question 31

Stain for Extranodal NK/T-cell Lymphoma

Answer 31

CD56

Question 32

Mutation/Translocation for Myelodysplastic Syndrome

Answer 32

Chrom 5q- Chrom 7, 9 deletions SF3B1

Question 33

Mutation/Translocation for Polycythemia Vera

Answer 33

JAK2

Question 34

Mutation/Translocation for Idiopathic/1˚ Myelofibrosis

Answer 34

JAK2, ~MPL

Question 35

Mutation/Translocation for Essential Thrombocytosis

Answer 35

JAK2, MPL CALR

Question 36

Mutation/Translocation for Langerhans Cell Histiocytosis

Answer 36

BRAF

Question 37

Stains for Langerhans Cell Histiocytosis

Answer 37

HLA-DR3, S-100, CD1a

Question 38

Mutation/Translocation for CML

Answer 38

t(9;22) - BCR/ABL

Question 39

Stains for AML-M0

Answer 39

MPO-, NSE-

Question 40

Stains for AML-M1

Answer 40

MPO+, NSE-

Question 41

Mutation/Translocation for AML-M2

Answer 41

t(8;21) - RUNX1

Question 42

Mutation/Translocation for AML-M3

Answer 42

t(15;17) - RARa

Question 43

Mutation/Translocation for AML-M4

Answer 43

inv(16)

Question 44

Stains for AML-M4

Answer 44

MPO+, NSE+

Question 45

Mutation/Translocation for AML-M5

Answer 45

11q23

Question 46

Stains for AML-M5

Answer 46

MPO-, NSE+

Question 47

All AML will stain for

Answer 47

CD33, 34

Question 48

Mutation/Translocation for AML d/t Topo2 inhibitors

Answer 48

MLL