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Zak, Heme/Lymph > Mutations/Stains > Flashcards

Mutations/Stains Flashcards

1
Q

Mutation/Translocation for B-ALL

A

t(12;21): t(9;22), t(1;19), t(4;11)

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2
Q

Stains for B-ALL

A

CD10, 19, 20, PAX5

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3
Q

Mutation/Translocation for T-ALL

A

NOTCH1, BCL6

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4
Q

Stains for T-ALL

A

CD1, 2, 3, 5, 7, 8

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5
Q

All ALL’s will stain + for

A

TdT, PAS

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6
Q

Mutation/Translocation for Follicular Lymphoma

A

t(14;18) - BCL2 MLL2

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7
Q

Stains for Follicular Lymphoma

A

CD10,19,20,BCL2 ~BCL6

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8
Q

Mutation/Translocation for DLBCL

A

BCL6

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9
Q

Virus associated w/ Immunodeficient CBCL

A

EBV

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10
Q

Virus associated w/ 1˚ Pleural Effusion type of DLBCL

A

HHV8

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11
Q

Stains for DLBCL

A

CD19, 20, BCL6 ~BCL2, ~CD10

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12
Q

Mutation/Translocation for Burkitt Lymphoma

A

t(8;14) - MYC

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13
Q

Stains for Burkitt Lymphoma

A

CD10, 19, 20, BCL6, Ki-67

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14
Q

Mutation/Translocation for Mantle Cell Lymphoma

A

t(11;14) - Cyclin D1

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15
Q

Stains for Mantle Cell Lymphoma

A

CD5, 19, 20

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16
Q

Mutation/Translocation for Marginal Zone Lymphoma

A

t(11;18) t(14;18) t(1;14)

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17
Q

Stains for Marginal Zone Lymphoma

A

BCL10, MALT1, BCL2?

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18
Q

Stains for HL - Classic Types

A

CD15, 30

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19
Q

Stains for HL - Lymphocyte Predominant Type

A

CD 19, 20, BCL6

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20
Q

Mutation/Translocation for Multiple Myeloma

A

Cyclin D1 = good 13q, 17p, t(4;14) = bad

21
Q

Stains for Multiple Myeloma

22
Q

Mutation/Translocation for Waldenstrom’s Macroglobulinemia (Lymphoplasmacytic Lymphoma)

23
Q

Stains for Waldenstrom’s Macroglobulinemia (Lymphoplasmacytic Lymphoma)

A

CD19, 20, 22, PAS

24
Q

Mutation/Translocation for Hairy Cell Leukemia

25
Q

Stains for Hairy Cell Leukemia

A

CD19, 20, 25, 11c, 103 TRAP, Annexin A1

26
Q

Mutation/Translocation for Anaplastic Large Cell Lymphoma

A

ALK t(2;5)

27
Q

Stains for Anaplastic Large Cell Lymphoma

28
Q

Stains for Mycosis/Sezary

A

CLA, CCR4, CCR10

29
Q

Mutation/Translocation for Large Granular Lymphocytic Leukemia

30
Q

Stains for Large Granular Lymphocytic Leukemia

A

T-cell = CD3 NK-cell = CD56

31
Q

Stain for Extranodal NK/T-cell Lymphoma

32
Q

Mutation/Translocation for Myelodysplastic Syndrome

A

Chrom 5q- Chrom 7, 9 deletions SF3B1

33
Q

Mutation/Translocation for Polycythemia Vera

34
Q

Mutation/Translocation for Idiopathic/1˚ Myelofibrosis

A

JAK2, ~MPL

35
Q

Mutation/Translocation for Essential Thrombocytosis

A

JAK2, MPL CALR

36
Q

Mutation/Translocation for Langerhans Cell Histiocytosis

37
Q

Stains for Langerhans Cell Histiocytosis

A

HLA-DR3, S-100, CD1a

38
Q

Mutation/Translocation for CML

A

t(9;22) - BCR/ABL

39
Q

Stains for AML-M0

A

MPO-, NSE-

40
Q

Stains for AML-M1

A

MPO+, NSE-

41
Q

Mutation/Translocation for AML-M2

A

t(8;21) - RUNX1

42
Q

Mutation/Translocation for AML-M3

A

t(15;17) - RARa

43
Q

Mutation/Translocation for AML-M4

44
Q

Stains for AML-M4

A

MPO+, NSE+

45
Q

Mutation/Translocation for AML-M5

46
Q

Stains for AML-M5

A

MPO-, NSE+

47
Q

All AML will stain for

48
Q

Mutation/Translocation for AML d/t Topo2 inhibitors

Zak, Heme/Lymph (15 decks)

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