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Zak, Heme/Lymph > Ch. 13 Morphology > Flashcards

Ch. 13 Morphology Flashcards

1
Q

When would you see Dohle bodies and Toxic granules

A

Leukocytosis (sepsis)

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2
Q

Engorged, swollen, painful LNs

A

Acute Nonspecific Lymphadenitis

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3
Q

Non-tender LNs with follicular and paracortical, hyperplasia as well as sinus histiocytosis

A

Chronic Nonspecific Lymphadenitis

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4
Q

Hypercellular BM with a “starry sky” appearance that is PAS+ and MPO-

A

Acute Lymphoblastic Leukemia/Lymphoma (ALL)

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5
Q

Presence of “smudge cells” (small, round lymphocytes that get disrupted when making a smear) and scattered spherocytes

A

Chronic Lymphoblastic Leukemia (CLL)

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6
Q

Presence of centrocytes and centroblasts and parafollicular lymphoid aggregates in BM

A

Follicular Lymphoma (NHL)

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7
Q

Sheets of large B-cells

A

Diffuse Large B-Cell Lymphoma

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8
Q

Starry sky appearance in BM and aspirats show tumor cells with royal blue cytoplasm

A

Burkitt Lymphoma

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9
Q

Homogenous populations of small lymphoctyes with irregular/occassionally deeply clefted/cleaved nuclear contours and a nodular follicular pattern with no proliferation centers

A

Mantle Cell Lymphoma

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10
Q

Cells with two nuclei surrounded by a clear zone - Owls eyes

A

Reed-Sternberg cells of HL

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11
Q

In which disease do cells sometimes undergo ‘mummification’ where they shrink and become pyknotic

A

Classic HL

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12
Q

Lacunar RS cells and deposition of collagen bands that divide LNs into nodules

A

Nodular sclerosis HL

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13
Q

Frequent RS cells and nodules w/out fibrous septae

A

Mixed cellularity HL

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14
Q

Reactive lymphocytes with frequent mononuclear variants and RS cells

A

Lymphocyte rich HL

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15
Q

Abundance of RS cells and small amounts of lymphocytes

A

Lymphocyte depletion HL

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16
Q

L and H variants of cells with multilobed nucleus resembling popcorn kernel and few RS cells

A

Lymphocyte predominance

17
Q

Presence of flame cells, mott cells, russell bodies, and dutcher bodies

A

Multiple Myeloma

18
Q

Presence of Bence-Jones proteins

A

Multiple Myeloma (kidney)

19
Q

Russell bodies and Dutcher bodies with PAS+ inclusions and infiltration of nerve roots, meninges, and brain

A

Lymphoplasmacytic Lymphoma

20
Q

Pale blue cytoplasm with thread/bleb-like extensions, dry tap on BM aspirate and massive splenomegaly

A

Hairy Cell Leukemia

21
Q

Hallmark cells containing horse-shoe shaped nuclei and voluminous cytoplasm

A

Anaplastic Large Cell Lymphoma (ALK+)

22
Q

Cloverleaf/flower cells with multilobulated nuclei

A

Adult T-Cell Leukemia/Lymphoma

23
Q

Neoplastic T cells with a cerebriform appearance infiltrate the epidermis and upper dermis

A

Mycosis Fungoides

24
Q

Large lymphocytes with abundant blue cytoplasm and a few coarse granules in peripheral blood smears

A

Large Granular Lymphocytic Leukemia

25
Q

Needle-like azurophilic granules present in the cytoplasm (Auer Rods)

A

Acute Myeloid Leukemia

26
Q

Cells that lack Auer rods and are NSE+

A

Monoblasts

27
Q

Hypercellular BM with dysplastic/disordered differentiation w/in the BM and presence of ring sideroblasts, Pseudo-Pelger-Huet cells and Pawn Ball Megakaryocytes

A

Myelodysplastic syndrome

28
Q

What are Pseudo-Pelger-Huet cells

A

Neutrophils with only 2 nuclear lobes

29
Q

What are Pawn Ball Megakaryocytes

A

Neutrophils with only 1 nuclear lobe

30
Q

Hypercellular BM with a high eosinophil, basophil, and neutrophil count and “sea-blue Histiocytes”

A

Myeloproliferative disorder

31
Q

Hypercellular marrow that becomes fibrotic causing EMH and an increase in RBCs

A

Polycythemia Vera

32
Q

Presence of leukoerythroblastosis, poikilocytosis, and dacryocytes with potential for Osteosclerosis to form

A

Primary Myelofibrosis

33
Q

Pentalaminar tubules with dilated terminal ends producing tennis racket-like appearance (Birbeck granules)

A

Langerhans Cell Histiocytosis

34
Q

Pale, wedge-shaped, subcapsular with overlying fibrin covered capsule in the spleen

A

Bland infarct

35
Q

Appearance modified by suppurative necrosis with large scars forming during the healing process

A

Septic infarcts

36
Q

Medullary-type epithelial cells that are elongated/spindle shaped

A

Noninvasive Thymoma

37
Q

Cortical epithelial cells with abundant cytoplasm and rounded vesicular nuclei

A

Invasive Thymoma

38
Q

Fleshy, invasive masses with cytologic atypia

A

Thymic Carcinoma

Zak, Heme/Lymph (15 decks)

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