Ch. 13 Morphology Flashcards
When would you see Dohle bodies and Toxic granules
Leukocytosis (sepsis)
Engorged, swollen, painful LNs
Acute Nonspecific Lymphadenitis
Non-tender LNs with follicular and paracortical, hyperplasia as well as sinus histiocytosis
Chronic Nonspecific Lymphadenitis
Hypercellular BM with a “starry sky” appearance that is PAS+ and MPO-
Acute Lymphoblastic Leukemia/Lymphoma (ALL)
Presence of “smudge cells” (small, round lymphocytes that get disrupted when making a smear) and scattered spherocytes
Chronic Lymphoblastic Leukemia (CLL)
Presence of centrocytes and centroblasts and parafollicular lymphoid aggregates in BM
Follicular Lymphoma (NHL)
Sheets of large B-cells
Diffuse Large B-Cell Lymphoma
Starry sky appearance in BM and aspirats show tumor cells with royal blue cytoplasm
Burkitt Lymphoma
Homogenous populations of small lymphoctyes with irregular/occassionally deeply clefted/cleaved nuclear contours and a nodular follicular pattern with no proliferation centers
Mantle Cell Lymphoma
Cells with two nuclei surrounded by a clear zone - Owls eyes
Reed-Sternberg cells of HL
In which disease do cells sometimes undergo ‘mummification’ where they shrink and become pyknotic
Classic HL
Lacunar RS cells and deposition of collagen bands that divide LNs into nodules
Nodular sclerosis HL
Frequent RS cells and nodules w/out fibrous septae
Mixed cellularity HL
Reactive lymphocytes with frequent mononuclear variants and RS cells
Lymphocyte rich HL
Abundance of RS cells and small amounts of lymphocytes
Lymphocyte depletion HL
L and H variants of cells with multilobed nucleus resembling popcorn kernel and few RS cells
Lymphocyte predominance
Presence of flame cells, mott cells, russell bodies, and dutcher bodies
Multiple Myeloma
Presence of Bence-Jones proteins
Multiple Myeloma (kidney)
Russell bodies and Dutcher bodies with PAS+ inclusions and infiltration of nerve roots, meninges, and brain
Lymphoplasmacytic Lymphoma
Pale blue cytoplasm with thread/bleb-like extensions, dry tap on BM aspirate and massive splenomegaly
Hairy Cell Leukemia
Hallmark cells containing horse-shoe shaped nuclei and voluminous cytoplasm
Anaplastic Large Cell Lymphoma (ALK+)
Cloverleaf/flower cells with multilobulated nuclei
Adult T-Cell Leukemia/Lymphoma
Neoplastic T cells with a cerebriform appearance infiltrate the epidermis and upper dermis
Mycosis Fungoides
Large lymphocytes with abundant blue cytoplasm and a few coarse granules in peripheral blood smears
Large Granular Lymphocytic Leukemia
Needle-like azurophilic granules present in the cytoplasm (Auer Rods)
Acute Myeloid Leukemia
Cells that lack Auer rods and are NSE+
Monoblasts
Hypercellular BM with dysplastic/disordered differentiation w/in the BM and presence of ring sideroblasts, Pseudo-Pelger-Huet cells and Pawn Ball Megakaryocytes
Myelodysplastic syndrome
What are Pseudo-Pelger-Huet cells
Neutrophils with only 2 nuclear lobes
What are Pawn Ball Megakaryocytes
Neutrophils with only 1 nuclear lobe
Hypercellular BM with a high eosinophil, basophil, and neutrophil count and “sea-blue Histiocytes”
Myeloproliferative disorder
Hypercellular marrow that becomes fibrotic causing EMH and an increase in RBCs
Polycythemia Vera
Presence of leukoerythroblastosis, poikilocytosis, and dacryocytes with potential for Osteosclerosis to form
Primary Myelofibrosis
Pentalaminar tubules with dilated terminal ends producing tennis racket-like appearance (Birbeck granules)
Langerhans Cell Histiocytosis
Pale, wedge-shaped, subcapsular with overlying fibrin covered capsule in the spleen
Bland infarct
Appearance modified by suppurative necrosis with large scars forming during the healing process
Septic infarcts
Medullary-type epithelial cells that are elongated/spindle shaped
Noninvasive Thymoma
Cortical epithelial cells with abundant cytoplasm and rounded vesicular nuclei
Invasive Thymoma
Fleshy, invasive masses with cytologic atypia
Thymic Carcinoma
