Mutations/Stains - Reverse

Question 1

t(12;21): t(9;22), t(1;19), t(4;11)

Answer 1

Mutation/Translocation for B-ALL

Question 2

CD10, 19, 20, PAX5

Answer 2

Stains for B-ALL

Question 3

NOTCH1, BCL6

Answer 3

Mutation/Translocation for T-ALL

Question 4

CD1, 2, 3, 5, 7, 8

Answer 4

Stains for T-ALL

Question 5

TdT, PAS

Answer 5

All ALL’s will stain + for

Question 6

t(14;18) - BCL2 MLL2

Answer 6

Mutation/Translocation for Follicular Lymphoma

Question 7

CD10,19,20,BCL2 ~BCL6

Answer 7

Stains for Follicular Lymphoma

Question 8

BCL6

Answer 8

Mutation/Translocation for DLBCL

Question 9

EBV

Answer 9

Virus associated w/ Immunodeficient CBCL

Question 10

HHV8

Answer 10

Virus associated w/ 1˚ Pleural Effusion type of DLBCL

Question 11

CD19, 20, BCL6 ~BCL2, ~CD10

Answer 11

Stains for DLBCL

Question 12

t(8;14) - MYC

Answer 12

Mutation/Translocation for Burkitt Lymphoma

Question 13

CD10, 19, 20, BCL6, Ki-67

Answer 13

Stains for Burkitt Lymphoma

Question 14

t(11;14) - Cyclin D1

Answer 14

Mutation/Translocation for Mantle Cell Lymphoma

Question 15

CD5, 19, 20

Answer 15

Stains for Mantle Cell Lymphoma

Question 16

t(11;18) t(14;18) t(1;14)

Answer 16

Mutation/Translocation for Marginal Zone Lymphoma

Question 17

BCL10, MALT1, BCL2?

Answer 17

Stains for Marginal Zone Lymphoma

Question 18

CD15, 30

Answer 18

Stains for HL - Classic Types

Question 19

CD 19, 20, BCL6

Answer 19

Stains for HL - Lymphocyte Predominant Type

Question 20

Cyclin D1 = good 13q, 17p, t(4;14) = bad

Answer 20

Mutation/Translocation for Multiple Myeloma

Question 21

CD56, 138

Answer 21

Stains for Multiple Myeloma

Question 22

MYD88

Answer 22

Mutation/Translocation for Waldenstrom’s Macroglobulinemia (Lymphoplasmacytic Lymphoma)

Question 23

CD19, 20, 22, PAS

Answer 23

Stains for Waldenstrom’s Macroglobulinemia (Lymphoplasmacytic Lymphoma)

Question 24

BRAF

Answer 24

Mutation/Translocation for Hairy Cell Leukemia

Question 25

CD19, 20, 25, 11c, 103 TRAP, Annexin A1

Answer 25

Stains for Hairy Cell Leukemia

Question 26

ALK t(2;5)

Answer 26

Mutation/Translocation for Anaplastic Large Cell Lymphoma

Question 27

CD30

Answer 27

Stains for Anaplastic Large Cell Lymphoma

Question 28

CLA, CCR4, CCR10

Answer 28

Stains for Mycosis/Sezary

Question 29

STAT3

Answer 29

Mutation/Translocation for Large Granular Lymphocytic Leukemia

Question 30

T-cell = CD3 NK-cell = CD56

Answer 30

Stains for Large Granular Lymphocytic Leukemia

Question 31

CD56

Answer 31

Stain for Extranodal NK/T-cell Lymphoma

Question 32

Chrom 5q- Chrom 7, 9 deletions SF3B1

Answer 32

Mutation/Translocation for Myelodysplastic Syndrome

Question 33

JAK2

Answer 33

Mutation/Translocation for Polycythemia Vera

Question 34

JAK2, ~MPL

Answer 34

Mutation/Translocation for Idiopathic/1˚ Myelofibrosis

Question 35

JAK2, MPL CALR

Answer 35

Mutation/Translocation for Essential Thrombocytosis

Question 36

BRAF

Answer 36

Mutation/Translocation for Langerhans Cell Histiocytosis

Question 37

HLA-DR3, S-100, CD1a

Answer 37

Stains for Langerhans Cell Histiocytosis

Question 38

t(9;22) - BCR/ABL

Answer 38

Mutation/Translocation for CML

Question 39

MPO-, NSE-

Answer 39

Stains for AML-M0

Question 40

MPO+, NSE-

Answer 40

Stains for AML-M1

Question 41

t(8;21) - RUNX1

Answer 41

Mutation/Translocation for AML-M2

Question 42

t(15;17) - RARa

Answer 42

Mutation/Translocation for AML-M3

Question 43

inv(16)

Answer 43

Mutation/Translocation for AML-M4

Question 44

MPO+, NSE+

Answer 44

Stains for AML-M4

Question 45

11q23

Answer 45

Mutation/Translocation for AML-M5

Question 46

MPO-, NSE+

Answer 46

Stains for AML-M5

Question 47

CD33, 34

Answer 47

All AML will stain for

Question 48

MLL

Answer 48

Mutation/Translocation for AML d/t Topo2 inhibitors