Mutations/Stains - Reverse Flashcards
t(12;21): t(9;22), t(1;19), t(4;11)
Mutation/Translocation for B-ALL
CD10, 19, 20, PAX5
Stains for B-ALL
NOTCH1, BCL6
Mutation/Translocation for T-ALL
CD1, 2, 3, 5, 7, 8
Stains for T-ALL
TdT, PAS
All ALL’s will stain + for
t(14;18) - BCL2 MLL2
Mutation/Translocation for Follicular Lymphoma
CD10,19,20,BCL2 ~BCL6
Stains for Follicular Lymphoma
BCL6
Mutation/Translocation for DLBCL
EBV
Virus associated w/ Immunodeficient CBCL
HHV8
Virus associated w/ 1˚ Pleural Effusion type of DLBCL
CD19, 20, BCL6 ~BCL2, ~CD10
Stains for DLBCL
t(8;14) - MYC
Mutation/Translocation for Burkitt Lymphoma
CD10, 19, 20, BCL6, Ki-67
Stains for Burkitt Lymphoma
t(11;14) - Cyclin D1
Mutation/Translocation for Mantle Cell Lymphoma
CD5, 19, 20
Stains for Mantle Cell Lymphoma
t(11;18) t(14;18) t(1;14)
Mutation/Translocation for Marginal Zone Lymphoma
BCL10, MALT1, BCL2?
Stains for Marginal Zone Lymphoma
CD15, 30
Stains for HL - Classic Types
CD 19, 20, BCL6
Stains for HL - Lymphocyte Predominant Type
Cyclin D1 = good 13q, 17p, t(4;14) = bad
Mutation/Translocation for Multiple Myeloma
CD56, 138
Stains for Multiple Myeloma
MYD88
Mutation/Translocation for Waldenstrom’s Macroglobulinemia (Lymphoplasmacytic Lymphoma)
CD19, 20, 22, PAS
Stains for Waldenstrom’s Macroglobulinemia (Lymphoplasmacytic Lymphoma)
BRAF
Mutation/Translocation for Hairy Cell Leukemia
CD19, 20, 25, 11c, 103 TRAP, Annexin A1
Stains for Hairy Cell Leukemia
ALK t(2;5)
Mutation/Translocation for Anaplastic Large Cell Lymphoma
CD30
Stains for Anaplastic Large Cell Lymphoma
CLA, CCR4, CCR10
Stains for Mycosis/Sezary
STAT3
Mutation/Translocation for Large Granular Lymphocytic Leukemia
T-cell = CD3 NK-cell = CD56
Stains for Large Granular Lymphocytic Leukemia
CD56
Stain for Extranodal NK/T-cell Lymphoma
Chrom 5q- Chrom 7, 9 deletions SF3B1
Mutation/Translocation for Myelodysplastic Syndrome
JAK2
Mutation/Translocation for Polycythemia Vera
JAK2, ~MPL
Mutation/Translocation for Idiopathic/1˚ Myelofibrosis
JAK2, MPL CALR
Mutation/Translocation for Essential Thrombocytosis
BRAF
Mutation/Translocation for Langerhans Cell Histiocytosis
HLA-DR3, S-100, CD1a
Stains for Langerhans Cell Histiocytosis
t(9;22) - BCR/ABL
Mutation/Translocation for CML
MPO-, NSE-
Stains for AML-M0
MPO+, NSE-
Stains for AML-M1
t(8;21) - RUNX1
Mutation/Translocation for AML-M2
t(15;17) - RARa
Mutation/Translocation for AML-M3
inv(16)
Mutation/Translocation for AML-M4
MPO+, NSE+
Stains for AML-M4
11q23
Mutation/Translocation for AML-M5
MPO-, NSE+
Stains for AML-M5
CD33, 34
All AML will stain for
MLL
Mutation/Translocation for AML d/t Topo2 inhibitors