Description of Diseases Flashcards

1
Q

Nodules of hypercellularity in germinal centers d/t B-cell hyperproliferation in older adults

A

Follicular lymphoma

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2
Q

Proliferation of large B-cells in older men

A

DLBCL

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3
Q

Multiple lymphatic masses with African (jaw) and Sporadic (ab mass) forms

A

Burkitt lymphoma

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4
Q

CD4 cell neoplasm in pts w/ HTLV-1

A

Adult T-Cell Leukemia/Lymphoma

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5
Q

Mutations of germinal center B-cells w/ RS cells

A

HL

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6
Q

B-cell neoplasm in the nervous system of immunosuppressed pts

A

Primary CNS lymphoma

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7
Q

Accumulation of myeloblasts in BM in adults around 60 yo

A

AML

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8
Q

Increased proliferation of granulocyte and megakaryocyte progenitor cells in older men

A

CML

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9
Q

Increased production of lymphoblasts in children

A

ALL

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10
Q

Abnormal proliferation of mature B-cells in pts > 60 yo

A

CLL

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11
Q

Abnormal B-cell neoplasm w/ needle-like projections in men > 55 yo

A

Hairy Cell Leukemia

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12
Q

Inability to cleave vWF causing thrombus formation and subsequent hemolysis of RBCs

A

Thrombotic Thrombocytopenic Purpura (TTP)

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13
Q

AutoAb mediated destruction of platelets in kids or women > 40 yo

A

Idiopathic/Immune Thrombocytopenic Purpura (ITP)

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14
Q

Increased platelet number w/ no polycythemia or BM fibrosis in pts > 60 yo

A

Essential Thrombocytosis

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15
Q

Decreased Factor VIII and prolonged PTT

A

Hemophilia A (XR)

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16
Q

Decreased Factor IX and prolonged PTT

A

Hemophilia B (XR)

17
Q

Increased production of mature myeloid cells from disordered stem cell proliferation in pts > 50 yo

A

Myelodysplastic Syndrome

18
Q

Syndromes caused by JAK2 mutations in HSC causing increased RTK activity

A

Myeloproliferative Syndromes

  • Polycythemia Vera
  • Idiopathic/1˚ Myelofibrosis
  • Essential Thrombocytosis
19
Q

Increased BM production of RBCs w/ low EPO in middle aged pts

A

Polycythemia Vera

20
Q

Increased fibroblast activity in BM d/t increased PDGF and TGF-ß secretion

A

Idiopathic/1˚ Myelofibrosis

21
Q

Malignant proliferation of plasma cells in the BM

A

Multiple Myeloma

22
Q

Single bone lesion/mass w/ M spike

A

Solitary Myeloma

23
Q

Plasma cell malignancy w/ M-spike > 3 w/ no Sx’s that may progress to MM

A

Smoldering Myeloma

24
Q

Plasma cell malignancy w/ small M-spike w/ no Sx’s

A

MGUS

25
Q

POEMS syndrome

A
Polyneuropathy
Organomegaly
Endocrinopathy
M-spike
Skin changes
26
Q

Lymphoplasmacytic malignancy w/ defective chain synthesis affecting the Waldeyer’s ring

A

g-HCD (Franklins Disease)

27
Q

Lymphoplasmacytic malignancy w/ defective chain synthesis that infiltrates the SI causing chronic diarrhea

A

a-HCD (Seligmann’s Disease)

28
Q

Lymphoplasmacytic malignancy w/ defective chain synthesis and vacuoles w/in the malignant lymphocytes that occurs in pts w/ CLL

A

µ-HCD

29
Q

Lymphoplasmacytic lymphoma w/ HSM and severe hyperviscosity d/t secretion of M-protein

A

Waldenstrom’s Macroglobulinemia (Lymphoplasmacytic Lymphoma)

30
Q

Ig light chain disorder d/t clonal B-cell dysfunction

A

AL Amyloidosis

31
Q

AD deficiency of hydroxymethylbilane synthase w/ increased PBG, and ALA

A

Acute Intermittent Porphyria

32
Q

Deficiency of hepatic uroporphyrinogen decarboxylase w/ increased uroporphyrin and 7-carboxylate porphyrin

A

Polycythemia Cutanea Tarda