Description of Diseases

Question 1

Nodules of hypercellularity in germinal centers d/t B-cell hyperproliferation in older adults

Answer 1

Follicular lymphoma

Question 2

Proliferation of large B-cells in older men

Answer 2

DLBCL

Question 3

Multiple lymphatic masses with African (jaw) and Sporadic (ab mass) forms

Answer 3

Burkitt lymphoma

Question 4

CD4 cell neoplasm in pts w/ HTLV-1

Answer 4

Adult T-Cell Leukemia/Lymphoma

Question 5

Mutations of germinal center B-cells w/ RS cells

Answer 5

HL

Question 6

B-cell neoplasm in the nervous system of immunosuppressed pts

Answer 6

Primary CNS lymphoma

Question 7

Accumulation of myeloblasts in BM in adults around 60 yo

Answer 7

AML

Question 8

Increased proliferation of granulocyte and megakaryocyte progenitor cells in older men

Answer 8

CML

Question 9

Increased production of lymphoblasts in children

Answer 9

ALL

Question 10

Abnormal proliferation of mature B-cells in pts > 60 yo

Answer 10

CLL

Question 11

Abnormal B-cell neoplasm w/ needle-like projections in men > 55 yo

Answer 11

Hairy Cell Leukemia

Question 12

Inability to cleave vWF causing thrombus formation and subsequent hemolysis of RBCs

Answer 12

Thrombotic Thrombocytopenic Purpura (TTP)

Question 13

AutoAb mediated destruction of platelets in kids or women > 40 yo

Answer 13

Idiopathic/Immune Thrombocytopenic Purpura (ITP)

Question 14

Increased platelet number w/ no polycythemia or BM fibrosis in pts > 60 yo

Answer 14

Essential Thrombocytosis

Question 15

Decreased Factor VIII and prolonged PTT

Answer 15

Hemophilia A (XR)

Question 16

Decreased Factor IX and prolonged PTT

Answer 16

Hemophilia B (XR)

Question 17

Increased production of mature myeloid cells from disordered stem cell proliferation in pts > 50 yo

Answer 17

Myelodysplastic Syndrome

Question 18

Syndromes caused by JAK2 mutations in HSC causing increased RTK activity

Answer 18

Myeloproliferative Syndromes

• Polycythemia Vera
• Idiopathic/1˚ Myelofibrosis
• Essential Thrombocytosis

Question 19

Increased BM production of RBCs w/ low EPO in middle aged pts

Answer 19

Polycythemia Vera

Question 20

Increased fibroblast activity in BM d/t increased PDGF and TGF-ß secretion

Answer 20

Idiopathic/1˚ Myelofibrosis

Question 21

Malignant proliferation of plasma cells in the BM

Answer 21

Multiple Myeloma

Question 22

Single bone lesion/mass w/ M spike

Answer 22

Solitary Myeloma

Question 23

Plasma cell malignancy w/ M-spike > 3 w/ no Sx’s that may progress to MM

Answer 23

Smoldering Myeloma

Question 24

Plasma cell malignancy w/ small M-spike w/ no Sx’s

Answer 24

MGUS

Question 25

POEMS syndrome

Answer 25

``` Polyneuropathy Organomegaly Endocrinopathy M-spike Skin changes ```

Question 26

Lymphoplasmacytic malignancy w/ defective chain synthesis affecting the Waldeyer's ring

Answer 26

g-HCD (Franklins Disease)

Question 27

Lymphoplasmacytic malignancy w/ defective chain synthesis that infiltrates the SI causing chronic diarrhea

Answer 27

a-HCD (Seligmann's Disease)

Question 28

Lymphoplasmacytic malignancy w/ defective chain synthesis and vacuoles w/in the malignant lymphocytes that occurs in pts w/ CLL

Answer 28

µ-HCD

Question 29

Lymphoplasmacytic lymphoma w/ HSM and severe hyperviscosity d/t secretion of M-protein

Answer 29

Waldenstrom's Macroglobulinemia (Lymphoplasmacytic Lymphoma)

Question 30

Ig light chain disorder d/t clonal B-cell dysfunction

Answer 30

AL Amyloidosis

Question 31

AD deficiency of hydroxymethylbilane synthase w/ increased PBG, and ALA

Answer 31

Acute Intermittent Porphyria

Question 32

Deficiency of hepatic uroporphyrinogen decarboxylase w/ increased uroporphyrin and 7-carboxylate porphyrin

Answer 32

Polycythemia Cutanea Tarda