Neurulation - Final

Question 1

Describe the morphogenic processes of neurulation, and hinge points, cell movements etc.

Answer 1

1) The notoplate converge and extends to provide the neural plate via the planar cell polarity pathway. Medial hinge point forms and the neural plate tissue starts to elevate. Bending of the plate and closure is accomplish from the dorsal lateral hinge point. E and N cadherins, as well as folic acid are required for closure of neural crest.

Question 2

What forms the floor plate, and roof plate? What is the gradient of the neural tube?

Answer 2

Floor plate induced from Shh from the notochord. The Roof plate is induced by BMPs from the ectoderm. Ventral neural tube becomes motor neuron, and dorsal neural tube becomes interneurons.

Question 3

What are the sections of the brain, and what are their subsections?

Answer 3

Fore = tel and di
Mid = Mes
Hind = Me and My

Question 4

Difference between Pax6 and Rx homeodomain genes

Answer 4

Pax 6 provides crystalline, the Rx gene creates a retinal cup.

Question 5

of Eph and ephrin, which is the ligand, and which is the receptor?

Answer 5

Eph is the receptor, and ephrin is the ligand.

Question 6

Rhombomeres

Answer 6

Metameric components of the vertebrate hindbrain.