Egg Activation Flashcards
1
Q
What shows where sperm have penetrated the egg?
A
A calcium wave
2
Q
Which signaling pathway contributes to the calcium wave?
A
Ca2+ and IP3
3
Q
How is a calcium wave propogated?
A
IP3 serves as a initial trigger for calcium release, but calcium alone can propagate the chain reaction.
4
Q
What are the two major changes that come from Ca2+ and IP3?
A
Ca2+ increase throughout the cell, and stimulation of a Na+/H+ exchanger, which increases pH.
5
Q
What is immediate? RNA and protein synthesis
A
Protein synthesis, but not RNA.
6
Q
How does pronuclear migration work?
A
Guided by sperm aster. Dyne moves the female pronucleus along Mts.
7
Q
What are three human fertilization issues?
A
Fallopian tube obstructions, inefficient zona penetration, poor sperm mobility
