Axis Specification in Mammals/Ethics - Final Flashcards
1
Q
What is the relationship between Lats, Yap, Tead4, Cdx2, Oct4, and Nanog?
A
Lats can phosphorylate Yap. If Yap is not phosphorylated, it activates Tead4, then Cdx2, which down regulates Oct4 and Nanog. This means the cell can no longer maintain pluripotency.
2
Q
What acts as the Organizer in mammals?
A
The Node. Releases Organizer antagonist ventral signals.
