Neurotransmitter Synthesis & Vesicular Loading

Question 1

How are low. Molecular weight neurotransmitters synthesized?

Answer 1

Low molecular weight
• Synthesized in cytosol
• Loaded into vesicles
• Commonly small clear
• Vesicles tethered awaiting release

Question 2

How are high molecular weight Neurotransmitters synthesized?

Answer 2

High molecular weight
• Propeptides synthesized in somata
• Loaded into large dense-core vesicles with cleaving enzymes
• Peptide-containing vesicles stored farther from release sites than are small clear vesicle

Question 3

What. Is vesivular loading?

Answer 3

• Energy-driven pump loads vesicles with hydrogen ions

* Antiport substitutes transmitter for hydrogen