Neuronal Damage And Recovery Flashcards
If we end up with too many disconnected, unused cells floating around, we disrupt the
Efficiency, connectivity, and speed of the entire system
By what week in utero have we usually developed all requires nerve cells we will ever have
25th
But we have produced more than we need
Apoptosis
Programmed death as much of 50% of cells that aren’t well-connected or we already have a redundant connection
Intentional death of cell body itself
Synaptic pruning
Need to refine and support only efficient, necessary networks
Pruning away atonal connections that are not competitive, stimulated, used, or needed
Apoptosis is programmed “clean”
Phagocytosis is executed without any explosive, leaky, mess
Necrosis
Is messy unwanted phagocytosis, has a big mess on its hands
Tbi, cut off oxygen or blood
Spinal cord trauma
Bending, tearing, cutting, dislocation, hyperextension, hypereflexion
Damage depends on level if SC injury, degree of injury
Spinal cord injury- disease
Occlusion
Occlusion of arteries needed to supply neurons in the spinal cord
Anterior spinal artery occlusion due to atherosclerotic disease
Degeneration of neurons in the spinal cord
Amyotrophic lateral sclerosis- ALS
ALS
Progressive degeneration if lateral corticospinal tracts
Loss of anterior horn cells throughout sc and bs
Muscle atrophy, paresis, death
Spinal cord synapse are no longer available for motor control
Spinal cord disease
Tumor
Spinal cord disease inflammation
Transverse myelitis
Progressive inflammation and attack on myelin at one level of the sc
Better hope of recovery for this
Spinal cord injury
Unnatural movement of axons
Depending where damage is/how far extend into spinal cord- motor or sensory