Neuroimmunology Pharmacology Flashcards

1
Q

daclizumab (Zinbryra)

MOA

A

modulation of IL-2 mediated activation of lymphocytes

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2
Q

Glatiramer Acetate (Copaxone)

A

promotes anti-inflammatory Th2 shift of T cells in peripheral circulation

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3
Q

Inf b-1a (Avenox/Rebif)

MOA

A

anti-inflam: down regulates cytokines, MHC Ags, decrease transmigration of T lymphocytes across the BBB

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4
Q

Inf b-1b (Betaseron/
Extavia)
MOA

A

anti-inflam: down regulates cytokines, MHC Ags, decrease transmigration of T lymphocytes across the BBB

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5
Q

pegylated Inf b-1a (Plegridy)

MOA

A

anti-inflam mechanism

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6
Q
Dimethyl fumarate (Tecfidera)
MOA
A

unknown; activates Nrf2 pathway (involved in cellular response to oxidative stress)

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7
Q

Fingolimod (Gilenya)

MOA

A

binds to immune cells and sequesters them in lymph nodes, reducing availability for cell mediated immune response

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8
Q

Teriflunomide (Aubagio)

MOA

A

inhibits DNA synthesis in rapidly dividing cells such as lymphocytes. Alternate salvage pathway allows pyrimidine synthesis to continue at reduced rate in resting cells

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9
Q

Alemtuzumab (Lemtrada)

A

binds CD52 (cell surface Ag on T and B lymphocytes, nKC, macrophages) –> ab-dependent cytolysis and complement mediated lysis

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10
Q

Mitoxantrone (Novantrone)

A

inhibits DNA synthesis, reduces lymphocytes, reduces Th1 cytokines

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11
Q

Natalizumab (Tysabri)

A

binds to alpha4/beta 1 integrin on activated lymphocytes and monocytes; inhibits leukocyte migration across the BBB

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12
Q

Ocrelizumab (Ocrevus)

A

binds CD20, cell surface antigen on pre-B and mature B lymphocytes, causing antibody-dependent and complement-mediated cytolysis

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13
Q

ADR of alopecia and paresthesias

A

Teriflunamide (tears your hair out, also chemo like MOA)

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14
Q

Most likely to give an infusion rxn

A

Lemtrada (alemtuzamab)

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15
Q

ADR of hair thinning, mouth sores, blue green urine, bone marrow suppression

A

Mitoxantrone

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16
Q

ADR of increased risk of malignancy

A

Ocrevus

17
Q

Warning of ITP

A

Alemtuzumab

18
Q

bradycardia, macular edema and decreased PFTs

A

gilenya (fingolimod)

19
Q

Warning of cardiac toxicity

A

Mitoxantrone