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x_ RITE Review > Neuro-oncology > Flashcards

Neuro-oncology Flashcards

1
Q

Glial neoplasm with NECROSIS and perinecrotic pseudopallisaing

A

GBM

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2
Q

Fried Egg appearance

A

oligodendroglioma

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3
Q

perivascular pseudorosettes

A

ependymomas

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4
Q

true rosettes

A

ependymomas

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5
Q

homer-wright rosettes

A

medulloblastoma

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6
Q

Ki-67

A

marker of nuclear proliferation

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7
Q

Rosenthal fibers

A

astrocytoma (pleomorphic xantho- and pilocytic, alexander’s disease, chronic gliosis

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8
Q

subependymal giant cell astrocytoma

A

tuberous sclerosis

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9
Q

tumor that typically present with seizures

A

DNET, oligodendroglioma, gangliogliomas

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10
Q

VHL chrom, inheritance, tumor

A

cerebellar hemangioblastoma, chrom 3, AD

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11
Q

Zellballen arrangement of nests of cells

A

paraganglioma

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12
Q

common origin of brain mets

A

lung>breast

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13
Q

AFP stains for

A

embryonal carcinoma, endodermal sinus tumor

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14
Q

chromogranin

A

pituitary adenoma

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15
Q

Common leukocyte antigen

A

lymphoma, germinoma

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16
Q

Cytokeratin

A

craniopharyngioma, chordoma

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17
Q

Desmin

A

rhabdosarcoma, teratoma

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18
Q

Vimentin, epithelial membrane antigen

A

meningioma

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19
Q

GFAP

A

astrocytomas

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20
Q

HMB 45 s100

A

melanoma

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21
Q

immunoglobulin K and L chains

A

lymphoma

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22
Q

neurofilament and synaptophysin

A

ganglioma, PNET

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23
Q

S100

A

schwannoma, RCC, chordoma , PNET, glioma, neurofibroma

24
Q

transthyretin

A

choroid plexus tumors

25
Q

two phases of cell replication that are susceptible to radiation

A

G1 and M phases

26
Q

antibody associated with cerebellar degeneration and breast cancer

27
Q

sensory neuropathy and small cell (oat cell)

28
Q

opsoclonus and breast cancer

29
Q

Rosenthal Fibers (hair-like)

A

juvenile pilocytic astrocytoma

30
Q

pseudopallisading necrosis

31
Q

fried egg cells with chicken wire arrangement

A

oligodendroglioma

32
Q

true rosettes and pseudorosettes

33
Q

halo like fried egg but stains with synaptophysin and neuron specific enolase

A

central neurocytoma

34
Q

monosomy seen in meningiomas

35
Q

HomerWright rosette (central fibrillar material ringerd by cell nuclei ) seen in

A

medulloblastoma, pineocytoma and neuroblastoma

36
Q

abundant thin walled vascular channels interspersed with enlarged vacuolated stromal cells

A

hemangioblastoma

37
Q

Adamantinomatous pattern and wet keratin

A

craniopharyngiomas

38
Q

most common pineal tumor

39
Q

large polygonal cells with large nuclei and t-cell infiltrates

40
Q

monotonous polygonal cells

A

pituitary adenomas

41
Q

physaliphorus or bubble bearing cells in mucoid rich stroma

42
Q

NF1 vs NF2

A

NF1 optic glioma, Lisch nodules of iris and chrom17 neurofibromin NF2 is 22/merlin/no systemic disease/shwannoma

43
Q

IDH1

A

low grade gliomas

44
Q

marker for glial intermediate filaments

A

GFAP (astrocytoma)

45
Q

marker for epithelial intermediate filaments

A

cytokeratin (think carcinoma generally)

46
Q

marker for T cells

47
Q

marker for B cells

48
Q

marker for melanocytic cells

A

Melan-A HMB-45

49
Q

marker for lymphocytes

50
Q

chrom. deletion assocaited with progression in anaplastic astrocytoma and GBM

51
Q

better prognosis in oligodendroglioma

A

codeltion of 1p19q

52
Q

chroid plexus papillomas usually arise from which ventricle ?

53
Q

mutliple mets think

A

melanoma and small cell

54
Q

most common chrom defect in medulloblastoma and poor prognositc oncogene

A

chrom 17 and N-myc

55
Q

primary CNS lymphoma is usually what kind ?

A

diffuse B cell

x_ RITE Review (34 decks)

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