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x_ RITE Review > Neuro-oncology > Flashcards

Neuro-oncology Flashcards

1
Q

Glial neoplasm with NECROSIS and perinecrotic pseudopallisaing

A

GBM

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2
Q

Fried Egg appearance

A

oligodendroglioma

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3
Q

perivascular pseudorosettes

A

ependymomas

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4
Q

true rosettes

A

ependymomas

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5
Q

homer-wright rosettes

A

medulloblastoma

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6
Q

Ki-67

A

marker of nuclear proliferation

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7
Q

Rosenthal fibers

A

astrocytoma (pleomorphic xantho- and pilocytic, alexander’s disease, chronic gliosis

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8
Q

subependymal giant cell astrocytoma

A

tuberous sclerosis

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9
Q

tumor that typically present with seizures

A

DNET, oligodendroglioma, gangliogliomas

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10
Q

VHL chrom, inheritance, tumor

A

cerebellar hemangioblastoma, chrom 3, AD

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11
Q

Zellballen arrangement of nests of cells

A

paraganglioma

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12
Q

common origin of brain mets

A

lung>breast

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13
Q

AFP stains for

A

embryonal carcinoma, endodermal sinus tumor

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14
Q

chromogranin

A

pituitary adenoma

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15
Q

Common leukocyte antigen

A

lymphoma, germinoma

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16
Q

Cytokeratin

A

craniopharyngioma, chordoma

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17
Q

Desmin

A

rhabdosarcoma, teratoma

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18
Q

Vimentin, epithelial membrane antigen

A

meningioma

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19
Q

GFAP

A

astrocytomas

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20
Q

HMB 45 s100

A

melanoma

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21
Q

immunoglobulin K and L chains

A

lymphoma

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22
Q

neurofilament and synaptophysin

A

ganglioma, PNET

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23
Q

S100

A

schwannoma, RCC, chordoma , PNET, glioma, neurofibroma

24
Q

transthyretin

A

choroid plexus tumors

25
two phases of cell replication that are susceptible to radiation
G1 and M phases
26
antibody associated with cerebellar degeneration and breast cancer
Anti-YO
27
sensory neuropathy and small cell (oat cell)
anti-hu
28
opsoclonus and breast cancer
anti-ri
29
Rosenthal Fibers (hair-like)
juvenile pilocytic astrocytoma
30
pseudopallisading necrosis
GBM
31
fried egg cells with chicken wire arrangement
oligodendroglioma
32
true rosettes and pseudorosettes
epndymoma
33
halo like fried egg but stains with synaptophysin and neuron specific enolase
central neurocytoma
34
monosomy seen in meningiomas
22
35
HomerWright rosette (central fibrillar material ringerd by cell nuclei ) seen in
medulloblastoma, pineocytoma and neuroblastoma
36
abundant thin walled vascular channels interspersed with enlarged vacuolated stromal cells
hemangioblastoma
37
Adamantinomatous pattern and wet keratin
craniopharyngiomas
38
most common pineal tumor
germinoma
39
large polygonal cells with large nuclei and t-cell infiltrates
germinoma
40
monotonous polygonal cells
pituitary adenomas
41
physaliphorus or bubble bearing cells in mucoid rich stroma
Chordoma
42
NF1 vs NF2
NF1 optic glioma, Lisch nodules of iris and chrom17 neurofibromin NF2 is 22/merlin/no systemic disease/shwannoma
43
IDH1
low grade gliomas
44
marker for glial intermediate filaments
GFAP (astrocytoma)
45
marker for epithelial intermediate filaments
cytokeratin (think carcinoma generally)
46
marker for T cells
CD3
47
marker for B cells
CD 20
48
marker for melanocytic cells
Melan-A HMB-45
49
marker for lymphocytes
CD45
50
chrom. deletion assocaited with progression in anaplastic astrocytoma and GBM
p16
51
better prognosis in oligodendroglioma
codeltion of 1p19q
52
chroid plexus papillomas usually arise from which ventricle ?
lateral.
53
mutliple mets think
melanoma and small cell
54
most common chrom defect in medulloblastoma and poor prognositc oncogene
chrom 17 and N-myc
55
primary CNS lymphoma is usually what kind ?
diffuse B cell

x_ RITE Review (34 decks)

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