Neurocognitive Disorders

Question 1

Delirium

Answer 1

NO DURATION; specify if substance intoxication/withdrawal delirium; medication-induced or due to another medical condition; or due to multiple etiologies. Specify acute (lasting hours to days) or Persistent (weeks to months); specify hyperactive/hypoactive/mixed.

Question 2

Substance intoxication delirium

Answer 2

NO DURATION; specify if substance intoxication/withdrawal delirium; medication-induced or due to another medical condition; or due to multiple etiologies. Specify acute (lasting hours to days) or Persistent (weeks to months); specify hyperactive/hypoactive/mixed.

Question 3

Substance withdrawal delirium

Answer 3

NO DURATION; specify if substance intoxication/withdrawal delirium; medication-induced or due to another medical condition; or due to multiple etiologies. Specify acute (lasting hours to days) or Persistent (weeks to months); specify hyperactive/hypoactive/mixed.

Question 4

Medication-induced delirium

Answer 4

NO DURATION; specify if substance intoxication/withdrawal delirium; medication-induced or due to another medical condition; or due to multiple etiologies. Specify acute (lasting hours to days) or Persistent (weeks to months); specify hyperactive/hypoactive/mixed.

Question 5

Delirium due to another medical condition

Answer 5

NO DURATION; specify if substance intoxication/withdrawal delirium; medication-induced or due to another medical condition; or due to multiple etiologies. Specify acute (lasting hours to days) or Persistent (weeks to months); specify hyperactive/hypoactive/mixed.

Question 6

Delirium due to multiple etiologies

Answer 6

NO DURATION; specify if substance intoxication/withdrawal delirium; medication-induced or due to another medical condition; or due to multiple etiologies. Specify acute (lasting hours to days) or Persistent (weeks to months); specify hyperactive/hypoactive/mixed.

Question 7

Major and mild NCD due to Alzheimer’s disease

Answer 7

Insidious onset, gradual progression, with extended plateaus.

Question 8

Major and mild frontotemporal neurocognitive d/o

Answer 8

Insidious onset, gradual progression; behavior variant and language variant; relative sparing of learning and memory.

Question 9

Major and mild NCD with Lewy bodies

Answer 9

Insidious and gradual; core dx features: fluctuating cognition with pronounced variations in attention and alertness; recurrent VH that are well formed and detailed; spontaneous features of parkinsonism, with onset subsequent to the development of cognitive decline. Suggestive dx features: meets criteria for REM sleep behavior disorder; sever neuroleptic sensitivity.

Question 10

Major and mild vascular NCD

Answer 10

acute stepwise or fluctuating decline in cognition. Usually related to a cerebrovascular event; evidence for decline is prominent in complex attention (incl. processing speed).

Question 11

Major and mild NCD due to traumatic brain injury

Answer 11

Immediately after TBI.

Question 12

Substance/medication induced major and mild NCD

Answer 12

Does not occur during intoxication/withdrawal/delirium related the the medication or substance (think ETOH /inhalants / sedatives.)

Question 13

Major and mild NCD due to HIV infection

Answer 13

NO DURATION.

Question 14

Major and mild NCD due to prion disease

Answer 14

ONSET IS INSIDIOUS, PROGRESSION IS RAPID; think myoclonus and ataxia, biomarker evidence.

Question 15

Major and mild NCD due to Parkinson disease

Answer 15

INSIDIOUS ONSET, GRADUAL PROGRESSION; OCCURS IN SETTING OF ESTABLISHED PARKINSON’S DISEASE.

Question 16

Major and mild NCD due to Huntington disease

Answer 16

INSIDIOUS ONSET, GRADUAL PROGRESSION; clinically established Huntington’s disease or high risk based on family hx or genetic testing. CAG trinucelotide repeat expansion in HTT gene located on chromosome 4.

Question 17

Major and mild NCD due to multiple etiologies

Answer 17

NO DURATION.

Question 18

Major and mild NCD due to another medical condition

Answer 18

NO DURATION.