Nervous Tissue Flashcards
What gives rise to neuroblasts
Neuroepithelial cells form embryonic neuroectoderm
Neuroblasts give rise to what
neurons of the central nervous system (brain and spinal cord)
Neural crest cells are derived from what and give rise to what
Neuroectoderm and give rise ot neurons and neuroglial cells of the PNS
The neural tube has what kind of epithelium
Pseudostratified epithelium
The Neural tube is composed of pseudostratified epithelium that composed of what zones
Ventricular zone
Intermediate zone
The ventricular zone of the neural tube is made up of
Ventricular cells
The intermediate zone of the neural tube is what
area of destruction of excess neurons via apoptosis
What is the cortical plate (mantle layer)
area around the neural tube
composed of postmitotic neurons
Future gray matter (cell bodies, dendrites and unmyelinated axons)
What is the marginal layer
Area outside of the mantle layer
contains axons
future white matter (mylinated axons)
The ventricular zone gives rise to what
ependymoblasts, immature neurons, and glioblasts
Ependymoblasts develop into what
choroid plexus and ependymal cells and remain associated with the lumen fo the neural tube
Glioblasts migrate to the what and give rise to what
cortical plate (mantle layer) and give rise to astrocytes and oligodendrocytes
what are non-neuronal cells typically derived from embyronic neural crest tissue (expect microglia)
Glial cells
where does myelinization occur
In the cortical plate
Nerve tissues have irritability what does that mean
Specialized to receive stimuli
Nerve Tissue has conductibility what does that mean
Specialized to transmit impulses
Nonconductive cells that support and protect the neurons
neuroglial cells
Fundamental structural and functional unit of the nervous system
Neurons
What conducts impulses
Neurons
What are the two cellular components of nerve tissue
Neurons and neuroglial cells
What are the 3 parts of a neuron
Cell body (soma)
Dendrites
Axon
What part of a neuron houses the nucleus
The cell body
Nissl bodies (substance) of the cell body consists of what
RER and free ribosomes
The cell body has an extensive ____ visible with light microscopy and elaborate ___ strucutes
RER, Golgi
The cell body of neurons has abundant ____ and _______
Microtubules (neurotubules) and intermediate filaments (neurofilaments)
does the cell body of a neuron have abundant mitochondria
Yes
what are formed from lysomes and accumulate with age of the nueron
Lipofucsin
Cell bodies are associated with ______ and local potentials
Ligand gated channels
The cell bodies of neurons have what kind of channels
Ligand gated
The Nissl substance of the dendrites contains what
mitochondria and other cytoplasmic components as the cell body except the Golgi body
Dendrites may be studded with what
Dendritic spines
The dendrites tend to taper _____ and may branch
Distally
Dendrites are associated with what kind of channels
ligand gated channels
Dendrites have ligand gated channels and thus have what kind of potentials
local potentials
What is the site of origin of the axon
axon hillock
The axon hillock is devoid of what
Nissl substance
The axon hillock is associated with what
AP generation
The axon is associated with what kind of channels and potentials
voltage gated cation channels and action potentials
Axons contain _____ and _____
mitochondria and microtubules
Axons lack what three things
RER, ribosomes, and golgi apparatus
Axons have constant ____ throughout their length
Diameter
The axon terminates in branching
telodendrites
Telodenrites contain _____ and ____
synaptic vesicles and related proteins
Telodenrites form the ______
presynaptic membranes
what form the presynaptic membranes
telodendrites
Axons may be enclosed within a
mylein sheath
What is the purpose of dendritic spines
further increase surface area
Neurons can be according to
function, number of processes, length of axon
What are the 3 types of neurons by function
Sensory (afferent) neurons
Motor (efferent) neurons
Interneurons
Sensory (afferent) neurons function
Transmit sensory impulses from sensory receptors to CNS
What is the function of motor (efferent) neurons
Transmit impulses from CNS to a muscle or gland
Somatic motor neurons innervate what
skeletal muscles
Autonomic motor neurons innervate
glands, cardiac and smooth muscle
The autonomic motor neurons are divided into
parasympathetic and sympathetic neurons
Interneurons function
Transmit impulses within CNS and between sensory and motor neurons
What are the three classifications of neurons according to number of processes
Multipolar neurons, bipolar, Pseudounipolar
What classification according to number of processes are the most common morphological type
Multipolar neurons
Multipolar axons characteristics
single axon and multiple dendrites
Structure of Bipolar neurons
Have two processes, one at each end of the spindle-shaped neuron
Bipolar neurons are round in association of what
special senses such as olfactory and visual
Structure of Pseudounipolar neurons
Have a single process from the cell body that bifurcates into a central and peripheral process
Where are Pseudounipolar neurons found
Found in ganglia alongside spinal cord (dorsal root ganglia)
What are the two types of neurons classified by length of axon
Golgi I and Golgi II
Structure of golgi I neurons
neurons with long axons which leave the grey matter of which they are part
Structure of golgi II neurons
Neurons with short axons which ramify through gray matter
What is a bundle of axons (fibers) in the PNS
Nerve
What is a bundle of axons (fibers) in the CNS
Tract
Aggregation of cell bodies and dendrites in the PNS
Ganglion
Aggregation of cell bodies and dendrites in the CNS
Nucleus
The epineurium covers what
the entire nerve
The epineurium is composed of what
Type I collagen and fibroblasts
The epineurium is supplied by what
Blood and lymphatic vessels
Is the epineurium a thick fibrous coat
Yes
The Perineurium is composed of
dense CT
What does the perineurium cover
Covers bundles of axons (fascicles) within the nerve
The epithelial-like fibroblasts on inner surface of the perineurium are joined by
tight junctions
- Zonulae occludens - Provide a permeability barrier - This layer has to rejoined in microsurgery for limb reattachment
What layer has to be rejoined in microsurgery for limb reattachment
Epithelial-like fibroblasts on inner surface are joined by tight junctions
Which layer makes up the blood nerve barrier
Perineurium
What is the blood nerve barrier
endothelial cells of vessels are also linked by tight junction
What is the endoneurium composed of
Type III collagen
The endoneurium is surrounds what
individual fibers and Schwann cells
Which layer of microarchitecture is thin layer of reticular CT around nerve fibers
Endoneurium
What are ways nerve membranes are specialized
Receptors, ion channels, Presynaptic membrane, Postsynaptic membrane,
Ligand-gated channels are located on
dendrites and cell bodies
Potassium channels are located on what part of neuron
Axon
Voltage-gated sodium channels are located on what part of a neuron
Axon
Voltage-gated calcium channels are located on what part of a neuron
Axon
Characteristics of presynaptic membrane
Synaptic vesicles, vesicular docking proteins and synapsin filaments, dense bodies, Mitochondria, voltage-gated calcium channels
Postsynaptic membrane characteristics
Receptors and ligand-gated ion channels
Anterograde direction
cell body toward distal end of axon
Anterograde utilizes what
Kinesin
Rates of transport for anterograde
slow (1-6mm per day), Intermediate (50-100mm per day), Fast (400mm per day)
Slow anterograde transport has how many systems and what are they called
Two, SCa and SCb
Slow transport is only used in what direction of transport
Anterograde
What uses SCa anterograde transport
preassembled microtubles and neurofilaments
What uses SCb anterograde transport
Enzymes, actin, clathrin
What uses intermediate anterograde transport
mitochondria and other membrane-bound organelles
What uses fast anterograde transport
Synaptic vesicles and neurotransmitters
Fast anterograde transport utilizes
Microtubule motors