Nervous Tissue Flashcards

1
Q

What gives rise to neuroblasts

A

Neuroepithelial cells form embryonic neuroectoderm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Neuroblasts give rise to what

A

neurons of the central nervous system (brain and spinal cord)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Neural crest cells are derived from what and give rise to what

A

Neuroectoderm and give rise ot neurons and neuroglial cells of the PNS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

The neural tube has what kind of epithelium

A

Pseudostratified epithelium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

The Neural tube is composed of pseudostratified epithelium that composed of what zones

A

Ventricular zone

Intermediate zone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

The ventricular zone of the neural tube is made up of

A

Ventricular cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

The intermediate zone of the neural tube is what

A

area of destruction of excess neurons via apoptosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the cortical plate (mantle layer)

A

area around the neural tube
composed of postmitotic neurons
Future gray matter (cell bodies, dendrites and unmyelinated axons)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the marginal layer

A

Area outside of the mantle layer
contains axons
future white matter (mylinated axons)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

The ventricular zone gives rise to what

A

ependymoblasts, immature neurons, and glioblasts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Ependymoblasts develop into what

A

choroid plexus and ependymal cells and remain associated with the lumen fo the neural tube

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Glioblasts migrate to the what and give rise to what

A

cortical plate (mantle layer) and give rise to astrocytes and oligodendrocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what are non-neuronal cells typically derived from embyronic neural crest tissue (expect microglia)

A

Glial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

where does myelinization occur

A

In the cortical plate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Nerve tissues have irritability what does that mean

A

Specialized to receive stimuli

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Nerve Tissue has conductibility what does that mean

A

Specialized to transmit impulses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Nonconductive cells that support and protect the neurons

A

neuroglial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Fundamental structural and functional unit of the nervous system

A

Neurons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What conducts impulses

A

Neurons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What are the two cellular components of nerve tissue

A

Neurons and neuroglial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What are the 3 parts of a neuron

A

Cell body (soma)
Dendrites
Axon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What part of a neuron houses the nucleus

A

The cell body

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Nissl bodies (substance) of the cell body consists of what

A

RER and free ribosomes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

The cell body has an extensive ____ visible with light microscopy and elaborate ___ strucutes

A

RER, Golgi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

The cell body of neurons has abundant ____ and _______

A

Microtubules (neurotubules) and intermediate filaments (neurofilaments)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

does the cell body of a neuron have abundant mitochondria

A

Yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

what are formed from lysomes and accumulate with age of the nueron

A

Lipofucsin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Cell bodies are associated with ______ and local potentials

A

Ligand gated channels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

The cell bodies of neurons have what kind of channels

A

Ligand gated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

The Nissl substance of the dendrites contains what

A

mitochondria and other cytoplasmic components as the cell body except the Golgi body

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Dendrites may be studded with what

A

Dendritic spines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

The dendrites tend to taper _____ and may branch

A

Distally

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

Dendrites are associated with what kind of channels

A

ligand gated channels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Dendrites have ligand gated channels and thus have what kind of potentials

A

local potentials

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

What is the site of origin of the axon

A

axon hillock

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

The axon hillock is devoid of what

A

Nissl substance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

The axon hillock is associated with what

A

AP generation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

The axon is associated with what kind of channels and potentials

A

voltage gated cation channels and action potentials

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

Axons contain _____ and _____

A

mitochondria and microtubules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

Axons lack what three things

A

RER, ribosomes, and golgi apparatus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

Axons have constant ____ throughout their length

A

Diameter

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

The axon terminates in branching

A

telodendrites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

Telodenrites contain _____ and ____

A

synaptic vesicles and related proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

Telodenrites form the ______

A

presynaptic membranes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

what form the presynaptic membranes

A

telodendrites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

Axons may be enclosed within a

A

mylein sheath

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

What is the purpose of dendritic spines

A

further increase surface area

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
48
Q

Neurons can be according to

A

function, number of processes, length of axon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
49
Q

What are the 3 types of neurons by function

A

Sensory (afferent) neurons
Motor (efferent) neurons
Interneurons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
50
Q

Sensory (afferent) neurons function

A

Transmit sensory impulses from sensory receptors to CNS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
51
Q

What is the function of motor (efferent) neurons

A

Transmit impulses from CNS to a muscle or gland

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
52
Q

Somatic motor neurons innervate what

A

skeletal muscles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
53
Q

Autonomic motor neurons innervate

A

glands, cardiac and smooth muscle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
54
Q

The autonomic motor neurons are divided into

A

parasympathetic and sympathetic neurons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
55
Q

Interneurons function

A

Transmit impulses within CNS and between sensory and motor neurons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
56
Q

What are the three classifications of neurons according to number of processes

A

Multipolar neurons, bipolar, Pseudounipolar

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
57
Q

What classification according to number of processes are the most common morphological type

A

Multipolar neurons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
58
Q

Multipolar axons characteristics

A

single axon and multiple dendrites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
59
Q

Structure of Bipolar neurons

A

Have two processes, one at each end of the spindle-shaped neuron

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
60
Q

Bipolar neurons are round in association of what

A

special senses such as olfactory and visual

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
61
Q

Structure of Pseudounipolar neurons

A

Have a single process from the cell body that bifurcates into a central and peripheral process

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
62
Q

Where are Pseudounipolar neurons found

A

Found in ganglia alongside spinal cord (dorsal root ganglia)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
63
Q

What are the two types of neurons classified by length of axon

A

Golgi I and Golgi II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
64
Q

Structure of golgi I neurons

A

neurons with long axons which leave the grey matter of which they are part

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
65
Q

Structure of golgi II neurons

A

Neurons with short axons which ramify through gray matter

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
66
Q

What is a bundle of axons (fibers) in the PNS

A

Nerve

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
67
Q

What is a bundle of axons (fibers) in the CNS

A

Tract

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
68
Q

Aggregation of cell bodies and dendrites in the PNS

A

Ganglion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
69
Q

Aggregation of cell bodies and dendrites in the CNS

A

Nucleus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
70
Q

The epineurium covers what

A

the entire nerve

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
71
Q

The epineurium is composed of what

A

Type I collagen and fibroblasts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
72
Q

The epineurium is supplied by what

A

Blood and lymphatic vessels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
73
Q

Is the epineurium a thick fibrous coat

A

Yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
74
Q

The Perineurium is composed of

A

dense CT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
75
Q

What does the perineurium cover

A

Covers bundles of axons (fascicles) within the nerve

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
76
Q

The epithelial-like fibroblasts on inner surface of the perineurium are joined by

A

tight junctions

- Zonulae occludens
- Provide a permeability barrier
- This layer has to rejoined in microsurgery for limb reattachment
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
77
Q

What layer has to be rejoined in microsurgery for limb reattachment

A

Epithelial-like fibroblasts on inner surface are joined by tight junctions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
78
Q

Which layer makes up the blood nerve barrier

A

Perineurium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
79
Q

What is the blood nerve barrier

A

endothelial cells of vessels are also linked by tight junction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
80
Q

What is the endoneurium composed of

A

Type III collagen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
81
Q

The endoneurium is surrounds what

A

individual fibers and Schwann cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
82
Q

Which layer of microarchitecture is thin layer of reticular CT around nerve fibers

A

Endoneurium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
83
Q

What are ways nerve membranes are specialized

A

Receptors, ion channels, Presynaptic membrane, Postsynaptic membrane,

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
84
Q

Ligand-gated channels are located on

A

dendrites and cell bodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
85
Q

Potassium channels are located on what part of neuron

A

Axon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
86
Q

Voltage-gated sodium channels are located on what part of a neuron

A

Axon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
87
Q

Voltage-gated calcium channels are located on what part of a neuron

A

Axon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
88
Q

Characteristics of presynaptic membrane

A

Synaptic vesicles, vesicular docking proteins and synapsin filaments, dense bodies, Mitochondria, voltage-gated calcium channels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
89
Q

Postsynaptic membrane characteristics

A

Receptors and ligand-gated ion channels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
90
Q

Anterograde direction

A

cell body toward distal end of axon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
91
Q

Anterograde utilizes what

A

Kinesin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
92
Q

Rates of transport for anterograde

A

slow (1-6mm per day), Intermediate (50-100mm per day), Fast (400mm per day)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
93
Q

Slow anterograde transport has how many systems and what are they called

A

Two, SCa and SCb

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
94
Q

Slow transport is only used in what direction of transport

A

Anterograde

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
95
Q

What uses SCa anterograde transport

A

preassembled microtubles and neurofilaments

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
96
Q

What uses SCb anterograde transport

A

Enzymes, actin, clathrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
97
Q

What uses intermediate anterograde transport

A

mitochondria and other membrane-bound organelles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
98
Q

What uses fast anterograde transport

A

Synaptic vesicles and neurotransmitters

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
99
Q

Fast anterograde transport utilizes

A

Microtubule motors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
100
Q

Is it true the active velocity fro the three speeds of anterograde transport is the same but the slower ones stop more

A

yes

101
Q

What is retrograde transport

A

from axon to cell body

102
Q

Retrograde transport utilizes what

A

cytoplasmic dynein

103
Q

What does retrograde transport carry

A

endocytosed material and recycled proteins

104
Q

What is the rate of retrograde transport

A

100-300 mm/day

105
Q

Viruses tend to use what type of transport

A

Retrograde

106
Q

what are non-neuronal cells typically derived from embryonic neural crest tissue

A

Glial cells “glue cells” (except microglia)

107
Q

Glial cells serve in various support function in the ___ and ___

A

PNS and expecially in the CNS

108
Q

Are glial cells capable of cell division under appropriate conditions

A

Yes

109
Q

what are the types of Glial Cells

A

Atrocytes, Oligodendrocytes, Schwann Cells, Microglial cells, Ependymal Cells

110
Q

Astrocytes are derived from what

A

Neural crest (neuroepithelium)

111
Q

Astroctyes are found in what system

A

CNS

112
Q

Astrocytes have numerous ______ with expanded feet (______) that terminate on capillaries or the pia mater

A

Processes, pediceles

113
Q

Where are fibrous astrocytes found

A

predominately in the white matter

114
Q

Which astrocytes have long processes with few branches

A

Fibrous

115
Q

Where are protoplasmic astroctyes found

A

predominantly in the gray matter

116
Q

Which astrocytes have shorter processes with many short branches

A

Protoplasmic astrocytes

117
Q

What are the functions of Astrocytes

A
  • Regulate composition of intercellular environment or entry of substances into it
  • Structural support
  • Blood-brain barrier
  • Development of cerebral cortex
  • Potassium sink
  • Secretion of neuron trophic factors
  • Uptake/metabolism of neurotransmitters
  • Help form noncollagenous scar tissue after injury to CNS
118
Q

What is the major component and additional components of the blood brain barrier

A

Main- Tight junctions between endothelial cells
additional- the basal lamina of the endothelial cells
- The perivascular astrocyte end-feet (pediceles)

119
Q

Oligodendrocytes are derived from what

A

Neural crest (neuroepithelium)

120
Q

Oligodendrocytes are only found in the

A

CNS

121
Q

What are the functions of the Oligodendrocytes

A
  • Closely associated with neuron cell bodies in gray matter and function as satellite cells
  • Surround axons of unmyelinated fibers in gray matter
  • Myelinate axons in the CNS
122
Q

Each oligodendrocyte myelinates

A

several axons in the CNS

123
Q

What are Schwann cells derived from

A

Neural crest (neuroepithelium)

124
Q

What are the functions of Schwann cells

A

Myelinate axons in the PNS

125
Q

Each Schwann cell mylinates

A

a section of a single axon in the PNS

126
Q

Microglial cells are derived from what

A

macrophage precursors (bone marrow)

127
Q

What are Microglial cell functions

A

Phagocytic in the PNS
Recruit leukocytes across the blood-brain barrier
Modulate initiate and progression of immune response along with astrocytes

128
Q

Microglia-mediated neurotoxicity takes place when _______ bind to PRRs and tigger an excessive immune response

A

Pathogen-associated molecular patterns (PAMPs)

129
Q

What is the massive microglial response to tissue damage that can be repetitive or destructive

A

Microgliosis

130
Q

What are pattern recognition receptors (PRRs) responsible for

A

are responsible for phagocytic functions
(identification of pathogens , production of pathogens, and production of extracellular superoxide, release of pro-inflammatory factors and removal of toxic substances by phagocytosis

131
Q

What are some examples of the ligands that can be recognized by several PRRs

A

amyloid-beta peptide (alzheimer’s disease), alpha- synuclein (Parkinson’s disease), and Human immunodeficiency virus (HIV)

132
Q

What are the histoligical characteristics of Ependymal Cells

A

Ciliated Cuboidal Cells

133
Q

What are the ependymal cells derived from

A

from Neuroepithelium

134
Q

Where are ependymal cells found

A

In the ventricular system of the CNS and in the Choroid plexus

135
Q

What are the functions of the ependymal cells

A

Function in Transport and in the choroid plexus they may be principle cell type that secrete cerebrospinal fluid

136
Q

Satellite cells are derived from what

A

The neural crest

137
Q

Where are satellite cells found

A

form moons (crescents) around cell bodies in ganglia

138
Q

What is the function of Satellite cells

A

Insulators

139
Q

The choroid epithelium is formed by _____ linked by _____ with apical ______

A

Cuboidal cells, tight junctions, microvilli

140
Q

The choroidal epithelial cells produce what

A

CSF

141
Q

What is ependymal epithelium linked by ______ with apitcal _____ and _____

A

belt desmosomes, microvilli and cilia

142
Q

What are tanycytes

A

specialized ependymal cells found in the third ventricle, have basal processes extending through the astrocytic processes layer to form end-feet on blood vessels.

143
Q

Tanycytes are linked to each other and to ependymal cells by what

A

tight junctions

144
Q

What wraps around the axon in the PNS

A

Schwann cell plasma membrane

145
Q

The Schwann cell cytoplasm is “squeezed” out, leaving behind ______ layers of membrane in PNS myelination

A

concentric

146
Q

What is the intraperiod line

A

Electron-dense line created by extracellular space between adjacent outer leaflets during PNS mylenation

147
Q

What are the internal and external mesaxon in the PNS mylenation

A

outer and innermost points of fusion between the outer leaflets (extracellular leaflets)

148
Q

What is a transmembrane protein that forms homodimers

A

Major Protein Zero

149
Q

Major Protein Zero is only found in the

A

PNS

150
Q

Homodimers form ______ with the opposing outer leaflets

A

Homotetramers

151
Q

The cytoplasmic domains in the intraperiod line may have ______ functions

A

signaling

152
Q

Charcot-Marie-Tooth disease is related to what part of PNS

A

Mutations of Major Protein Zero which is part of the intraperiod line

153
Q

What is major protein zero replaced by in the CNS

A

Proteolipid protein, which has four homophobic domiains

154
Q

Mutations in proteolipids lead to what disease

A

Pelizaeus-Merzbacher disease

155
Q

What is Charcot-Marie Tooth Disease

A

Demyelinating disorder of the PNS characterized by the progressive loss of both motor and sensory functions of the distal legs, Type 1B and Type 2 are caused by mutations in myelin protein zero (MPZ)/major protein zero

156
Q

What is the major dense line

A

Electron-dense line created by cytoplasmic space remnant between adjacent innner leaflets during mylenation

157
Q

What is an abundant protein associated with the inner leaflets in both the PNS and CNS

A

Myelin Basic Protein

158
Q

What is the function of myelin basic protein

A

May function to stabilize lipids in the leaflets

159
Q

Many forms of myelin basic protein are created by what

A

splicing of single gene

160
Q

What are schmidt-lanterman clefts (incisures)

A

residual areas of cytoplam within the major dense lines

161
Q

In the PNS a single axon is embedded in a

A

Schwann cell

162
Q

oligodendrocytes are derived from what

A

glioblasts

163
Q

The cell body of the _________ is not closely associated with the myelin sheath as the body of a _______

A

Oligodendrocyte, Schwann Cell

164
Q

Each ______ provides myelin sheath to several axons

A

Oligodendrocyte

165
Q

Each _____ forms a myelin sheath around a single axon

A

Schwann cell

166
Q

There is no _____ associated with the myelin sheath in the CNS

A

Basal Lamina

167
Q

Which of the nervous system do not have basal lamina associated with their myelin sheath

A

CNS

168
Q

Myelinated axons in the CNS lack a supporting _______, as do nerves in the PNS

A

CT

169
Q

The inner and outer layers of myelin end in separate loops near the node of Ranvier and no cytoplasm of the _______ is trapped. In _______ cells, the cytoplasm is retained

A

Oligodendrocytes, Schwann cells

170
Q

In the CNS, the surface of the node is contacted by _____ . In the PNS, the node is covered by _______

A

Astrocyte process, Schwann cell process

171
Q

The cytoplasmic process of adjacent oligodenrocytes do not _______. The space is occupied by an ______

A

interdigitate, astrocytic end-foot process

172
Q

Cytoplasmic process of adjacent Schwann cell in the PNS ______ at the node region

A

interdigitate

173
Q

Apposed membranes of myelinating Schwann Cells are linked by _____

A

autotypic junctions

174
Q

Why are Autotypic junctions named autotypic

A

because they are found between membranes of the same cells

175
Q

______ are seen between the axoleema surrounding the axon and the cytoplasmic loops adjacent to the nod of Ranvier (paranoidal loops) in PNS

A

Heterotypic tight junctions

176
Q

What are observed between interdigitating cell processes of adjacent Schwann cells and the incisors of Schmidt-Lanterman

A

Autotypic tight junctions

177
Q

_____ is concentrated in the paranoidal region and the incisors of Schmidt-Lanterman

A

Connexin 32

178
Q

Connexin 32 (Cx32) is expressed in

A

Schwann Cells

179
Q

Mutations in Cx32 gene determine the demyelinating X-linked _______

A

Charcot-Marie-Tooth Disease

180
Q

Myelin Protein zero (MPZ) is synthesized by

A

Schwann Cells

181
Q

Myelin protein zero (MPZ) interact with each other (_____) to stabilize apposed plasma membranes as )_______

A

homodimers, homotetramers

182
Q

The intracellular tail of MPZ has what

A

Signaling factors

183
Q

IN the CNS the hemophiliac interaction of plasma membrane-associated ______ stabilizes adjacent stacks of membranes of oligodendrocytes

A

Proteolipid protein (PLP)

184
Q

Proteolipid protein (PLP) has a ______ with short and long extracellular loops and two intracellular tails

A

Tetraspanin structure

185
Q

Myelin basic protein is common in

A

both the PNS and CNS

186
Q

The structure of Proteolipid protein (PLP)

A

tetraspanin structure, Two extracellular loops and four transmembrane domains with the N-termininal and the C-Terminal being intracellular tails

187
Q

What are the microscopic features of Multiple Sclerosis

A

Infiltration of inflammatory cells (T cells and Macrophages) inside and around multiple sclerosis plaques; and plaques of astrocytic aggregates

188
Q

What are four components of the presynaptic membrane

A

Voltage-gated calcium channels, SNAPs bind synaptic vesicles to presynaptic membrane, Vesicle docking proteins, Synapsins

189
Q

What are synapsins

A

filaments in the presynaptic membrane

190
Q

What are SNAP receptors found in presynaptic and synaptic vesicular membranes

A

Vesicle docking proteins

191
Q

Fusion of presynaptic vesicles is mediated by what two interacting cytosolic proteins

A

NSF (N-ethylmaleimide-sensitive fusion) and SNAPs (for soluble NSF attachment proteins)

192
Q

SNAPs and NSF are recruited by ____ to induce fusion of vesicle and target membrane

A

SNAREs

193
Q

What are the components of postsynaptic membrane responsible for the synapse

A

Neurotransmitter receptors

194
Q

Neuronal chemical messengers ___________ are stored in synaptic vesicles and transported to the synaptic terminal by anterograde transport

A

Acetylcholine, glutamate, y-aminobutyric acid (GABA) and others

195
Q

Anterograde transport is mediated by

A

Kinesin

196
Q

once neurotransmitters are taken up by the post synaptic membrane they are degraded by the

A

Mitochondrial enzyme monamine oxidase (MAO)

197
Q

What are the 6 types of synapses

A
Axosomatic
Axoaxonic
axodendritic
axospinous
excitatory
inhibitory
198
Q

Axon terminal synapses with the neuron cell body

A

Axosomatic

199
Q

Axon terminal synapses with another axon terminal

A

Axoaxonic

200
Q

Axon terminal synapses with a dendrite

A

Axodendritic

201
Q

Axon terminal synapses with a dendritic spine

A

Axospinous

202
Q

More positive end-plate potential (closer to threshold)

A

Excitatory

203
Q

More negative end-plate potential (farther form threshold)

A

Inhibitory

204
Q

The dendritic shaft contains _______. in contrast the dendritic spine cytoskeleton consists of ______ associated with the postsynaptic density

A

microtubules, actin filaments

205
Q

Nuerotransmitter receptors and ion channels are localized in the

A

postsynaptic density

206
Q

Tough thick sheet of dense fibrous CT

A

Dura Mater

207
Q

In the cranial cavity it lines the inside of the cranial vault bone and serves as the periosteum

A

Dura Mater

208
Q

Around the spinal cord, ______ forms a CT tube that is separated from the bone of the vertebral foramina by a space referred to as the epidural space

A

Dura Mater

209
Q

Within the dura mater are large, endothelial-lined _______ that receive blood from the cerebral drainage as well as cerebrospinal fluid via the arachnoid villi

A

Venous Sinuses

210
Q

Venous sinus receive blood from

A

cerebral drainage as well as cerebrospinal fluid via the arachnoid villi

211
Q

a layer of _____ cells separate the dura mater form the subdural space

A

dural border cells

212
Q

menix composed of delicate connective tissue

A

Arachnoid

213
Q

What does menix mean

A

Singular form of meninges

214
Q

The outer layer of the arachnoid faces the ______ and is made up of a single layer of ________

A

subdural space, arachnoid barrier cells

215
Q

The arachnoid is attached to the underlying ____ by delicatee strands of CT called what

A

pia mater, arachnoid trabeculae

216
Q

The spaces between the arachnoid and the pia mater are collectively referred to as the ______

A

Subarachnoid space

217
Q

What fills the subarachnoid space

A

CSF

218
Q

Arachnoid villi are mad up of what

A

arachnoid barrier cells

219
Q

Arachnoid villi extend from

A

the outer suface of the arachnoid into the overlying venous sinuses of the dura mater and allow cerebrospinal fluid to flow form the subarachnoid space into the dural sinuses

220
Q

What is the purpose of the arachnoid villi

A

They allow cerebrospinal fluid to flow form the subarachnoid space into the dural sinuses

221
Q

What is a thin, delicate sheet of CT that lies directly on the surfaces of the brain and Spinal cord

A

Pia mater

222
Q

Does pia mater follow the contours of the brain and dip into the sulci, lining them as well

A

Yes

223
Q

Pia mater is _____ with the perivascular CT of the cerebral and spinal cord blood vessels

A

continuous

224
Q

_____ is very tightly attached to the nervous tissue of the brain and spinal cord and cannot be removed without damaging the nervous tissue

A

Pia mater

225
Q

what are runnels covered with pia mater

A

perivascular spaces

226
Q

A blockage of the movement of CSF results in its accumulation in the ventricles and around the brain, a condition known as

A

hydrocephalus

227
Q

what is a highly infolded simple cuboidal epithelium that extends into the ventricles form the roof plate

A

choroid plexus

228
Q

Cuboidal cells of the choroid plexus are linked by _______ which form part of the CSF barrier

A

tight junctions

229
Q

Apical microvilli and infolding of basal membranes with abundant mitochondria in the choroid plexus are indicative of what

A

Active transport

230
Q

Capillaries to the choroid plexus are formed form endothelial cells that are ______

A

fenestrated

231
Q

___, ___,___ pumps in the apical membranes of the choroid plexus cells pump fluid into the ventricular lumen causing a flow of water, solutes, and proteins from the capillaries through the choroid plexus epithelium into the ventricles

A

Na+, K+, ATPase

232
Q

What is the simple cuboidal epithelium that lines the ventricles of the brain

A

Ependymal epithelium

233
Q

Ependymal epithelium is linked by _____ and have ____, _____,and ____

A

Zonula adherens, microvilli, cilia, and abundant microvilli

234
Q

What links ependymal cells

A

Zonula adherens

235
Q

The basal domains of ependymal cells are in contact with the ______, forming the glia limitans, which is part of the blood-brain barrier

A

astrocytic processes

236
Q

Astrocytes send processes to the surrounding ______ which is part of the blood-brain barrier

A

non-fenestrated

237
Q

what in the third ventricle are tightly linked to the adjacent ependymal cells and send processes through the glia limitans to form end-processes on underlying blood vessels

A

Tanycytes

238
Q

clusters of _____ neurons lie within the capsule of the dorsal root ganglia

A

pseudounipolar neurons

239
Q

Are postganglionic axons form the dorsal root ganglia mylenated

A

yes

240
Q

The dorsal root ganglia is surrounded by a capsule of CT called

A

epineurium

241
Q

What are satellite cells derived from

A

The Neural crest

242
Q

Satellite cells form a single layer around

A

The cell body of each neuron in the of the dorsal root ganglia

243
Q

the surfaces of satellite cells facing away form neurons are in contact with

A

a basal lamina

244
Q

Autonomic ganglia are encapsulated by the

A

epineurium

245
Q

Autonomic ganglia have clustered _____ neurons

A

multipolar

246
Q

clustered multipolar neurons of the autonomic nervous system receive input from

A

mylinated preganglionic neurons

247
Q

The postganglionic axons of the autonomic nervous system are

A

not mylinated

248
Q

Does the ANS have satellite cells around every neuron

A

Yes but less numerous than those in the dorsal root ganglia