Nervous System (Intro) Flashcards
Master control and communication system and has 3 overlapping functions
Nervous System
Uses its millions of sensory receptors to monitor changes occurring both inside and outside the body
Sensory Input
processes and interprets the sensory input and decides what should b done at each moment
Integration
Causes a response, or effect, by activating muscles, or glands
Motor Output
2 organisations of Nervous System
Structural Classification
Functional Classification
Give the structural classification of the nervous system
Nervous System (central nervous system and peripheral nervous system)
CNS (brain and spinal cord)
PNS (cranial and spinal nerves)
Give the functional classification of the nervous system
Peripheral Nervous System
(Autonomic Nervous System and Somatic Nervous System)
Autonomic
- Sympathetic
- Parasympathetic
Aka glial cells. Supports the nerve cells/ neurons. Non-excitable (do not produce action potential) cells and support cells
Neuroglia
Different Kinds of Neuroglia
- Microglia
- Oligodendrocytes
- Astrocytes
- Ependymal Cells
- Schwann Cells
- Satellite Cells
Macrophages in the central nervous system. Acts as defense against infection and injury
Microglia
Forms and maintain myelin sheath in the central nervous system
Oligodendrocytes
Star shaped cells and most numerous and abundant.
Astrocytes
Functions of Astrocytes
-Provides structural support to the central nervous system.
-Takes up extracellular potassium (K) ions.
- Regulates the extracellular concentration of neurotransmitter.
- Glycogen storage
- Capable of cell- multiplication/ replacement gliosis.
Located in the ventricle and central canal of the spinal cord. Assists in the circulation of cerebrospinal fluid (provides nourishment)
Ependymal Cells
Forms the myelin sheaths around nerve fibers in the peripheral nervous system
Schwann cells
Act as protective, cushioning cells for peripheral neuron cell bodies
Satellite cells
What are the parts of neuron
- Cell body
- Dendrites
- Axon
- Axon terminals
- Myelin Sheaths
- Nodes of Ranvier
Has nuclei, cytoplasm with typical organelles. (Action potential happens here)
Cell body
Highly branched structures that carry impulses (towards) to the cell body
Dendrites
Emerges at cone-shaped axon hillock. Conducts AWAY from cell body towards another neuron, muscle, or gland.
Axon
Contains synaptic vesicle that can release neurotransmitter
Axon terminals
Whitish, fatty material which has a waxy appearance. It protects and insulates the fibers and increases the transmission rate of the nerve impulses
Myelin Sheaths
Gaps or indentations and facilitates saltatory conduction
Nodes of Ranvier
Collection of cell bodies inside the CNS
Nuclei
Collection of cell bodies outside the CNS
Ganglia
Bundles of nerve fibers running through the CNS
Tracts
Bundles of nerve running through the PNS
Nerves
Found inside the brain but found outside of the spinal cord. Consists of dense collection of myelinated fibers (tracts)
White Matter
Found outside the brain but inside the spinal cord. Contains mostly of unmyelinated fibers and cell bodies.
Gray Matter
What are the functional classes of neurons
- Sensory ( Afferent )
- Motor ( Efferent )
- Interneuron
Conveys impulses into the CNS
Examples are dorsal root ganglion, cutaneous sense organ, and proprioceptor (sense of direction and place)
Sensory (Afferent)
Convey impulses from brain / spinal cord out through PNS to effector (muscle or organ)
Motor (Efferent)
aka “associated neurons” most are within the cns and it transmits impulses between sensory and motor neuron. Acts as a bridge
Interneuron
Structural Classes of Neurons
- Multipolar
- Bipolar
- Unipolar
Have several/ many dendrites and 1 axon. Most common type in the CNS. Examples are; motor pyramidal, purkinje cell.
Multipolar
One dendrite and 2 axon. Example are Retina of the eye, inner ear, and nose.
Bipolar
Have fused dendrite and axon. Touch and pain sensory neuron. Example (sensory neuron of spinal nerves)
Unipolar
Two major functional properties of nervous system
- Irritability
- Conductivity
also called as the nerve impulse in neurons
Action Potential
What is the normal resting potential
-70 mv
An increase in membrane potential of 15-30 mV usually is required to cause an explosive development of action potential.
All or none principle
Overshoot period/ phase caused by the fast opening of the voltage gated Na channel (opening of activation gate). There is also a sodium influx and the charge of the cell becomes positive.
Depolarization
How many mv does depolarization starts
-55mv
Cause by the fast closure of voltage gated sodium channels. There is a potassium efflux and the charge of the cell becomes negative.
Repolarization
Aka positive after potential. Caused by the slow and late closure of voltage gated potassium channels. The charge of the cell becomes more negative.
Hyperpolarization
A state wherein a positive charge is outside and negative charge inside the cell. This is due to the activation of sodium- potasium atpase pump. This is where the charge of the cell returns to normal membrane potential
Resting membrane potential
How many NA and K is in the resting membrane potential?
- 3 NA (OUTSIDE)
+ 2 K (INSIDE)
What are the normal resting membrane potential of each system
NN -70mV
Skeletal Muscle -90mV
Cardiac Muscle -85mV
Smooth muscle - 40mV to -60mV
GI tract -56mV
What are the phases of action potential?
Depolarization
Repolarization
Hyperpolarization
Resting Membrane Potential
2 Refractory Period
Absolute Refractory Period
Relative Refractory Period
Period during which a 2nd action potential cannot be elicited even with a strong stimulus. At the (30mV) peak of depolarization.
Absolute Refractory Period
Starts at the 1/3 of repolarization onwards. Stronger than normal stimulus and elicits new action potential.
Relative Refractory Period
Explain Neuromuscular Junction
- Action potential reaches presynaptic terminal
- Depolarization in PT opens ion channel that allows calcium into the cell
- Calcium trigger release of neurotransmitter from vesicles.
- Neurotransmitter binds to receptor sites
- Opening and closing of channels causes change in postsynaptic membrane potential
- Action potential propagates through next cell
- Neurotransmitter is inactivated
3 overlapping function of Nervous system
Sensory Input
Integration
Motor Output