Nervous System Flashcards
What is a system?
collection of different organs and tissues that has a specific function
What is the nervous system made up of?
a network of nerve cells (neurons and fibres)and their supporting cells
What does the nervous system basically do?
transmit nerve impulses between different parts of the body
What is the basic function of the nervous system?
allows sentient organisms to live effectively in their environment
What are ganglia?
collections of cell bodies
What are the 4 key functions of the nervous system?
sense and monitor environment
respond, react and move around environment
integrate, process and store information
maintain internal stasis of the body
What tissues and cells does sensing and monitoring the environment involve?
sensory tissues and organs, sensory nerves
What cells and tissues are involved in responding to and moving around the environment?
motor nerves and muscles
What cells and tissues are involved in maintaining internal stasis of the body?
motor nerves, smooth/cardiac muscle and glands
What are the two locations of the nervous system?
central nervous system and peripheral nervous system
What is the CNS comprised of?
brain and spinal chord
What is the PNS comprised of?
all nerves that are not found in the brain/spinal chord
What can the sensory nervous system also be known as?
afferent
What can the motor nervous system also be known as?
efferent
What is the difference between somatic and autonomic nervous systems?
somatic is voluntary and autonomic is involuntary
What are glia?
supporting cells of CNS and PNS
How does regeneration of nerves differ between CNS and PNS?
CNS- nerves do not regenerate after injury, there is no secretion of growth factors and inhibitory factors are actually released
PNS- nerves regenerate well after injury
What are the 2 branches of the autonomic nervous system?
sympathetic and parasympathetic
What does the sympathetic nervous system do?
fight of flight mechanism, speeds things up and diverts blood where it is needed (e.g. away from digestive system towards muscles)
What does the parasympathetic nervous system do?
rest and digest mechanism, slows everything down, diverts blood back to slower areas (e.g. towards digestive system)
What main divisions of the nervous system are the sympathetic and parasympathetic systems associated with?
CNS and PNS
What is a neuron?
the functional unit of the nervous system
What 3 types of neuron are there?
sensory, motor and interneurons
What are neurons specialised to do?
detect and react to stimuli
What do neurons generate, conduct and transmit?
nerve impulses
What are the 3 main areas on a neuron?
axon, dendrites and terminal synapses
How does the signal flow through a neuron?
dendrites-axon-terminal synapse
what do neuroglia do?
surround neurons
What do neurons use synapses for?
to communicate with other neurons or effector target cells
Where are the 3 main locations of synapses?
axon to dendrite, axon to cell body, axon to axon
Basically describe how a synapse works?
nerve impulse reaches terminal, stimulates the release of synaptic vesicles containing neurotransmitter. These leave the cell by exocytosis, cross the synaptic cleft to receptors on next cell surface
What is mylination?
surrounding of axon by glial cells to improve rate of conduction
What is the node of ranvier?
unmylinated area of nerve cells
Which cells are involved in mylination in the CNS?
oligodendrites
Whic cells are involved in mylination in the PNS?
schwann cells
How are axons mylinated differently in CNS and PNS?
CNS- each cell wraps around a different part of the axon
PNS- axon is mylinated by single cell that is wrapped/spiralled around
What is the CNS housed within?
bone
What bones are the brain and spinal cord housed in?
cranium and vertebrae
What is the name for the 3 layers of tissue which surround the CNS?
meninges
What are the 3 layers of meninges?
dura mater, arachnoid mater, pia mater
What is the dura mater like?
tough, outer layer of meninges
What is the arachnoid mater like?
web like appearance, middle layer of meninges
What is the pia mater like?
pink in colour, sits directly on top of spinal cord and bran, thinnest layer
What do the meninges do?
support and protect CNS and produce cerebral spinal fluid
What do spaces between meningeal layers house?
CSF and blood vessels
Where is the grey and white matter located in the spinal cord and what do they contain?
grey: houses cell bodies, located inside white matter which contains axons
Where is the grey and white matter located in the brain and what do they contain
grey: houses cell bodies and is located outside of the white matter which contains axons
Why is white matter white?
mylination of axons
Where does the spinal cord exit the brain?
at the foramen magnum
What is the foramen magnum?
hole at the bottom of the skull through which the spinal cord exits
Where does the spinal cord begin?
at the exit of the brain
What are the 5 sections of the spine?
cervical, thoracic, lumbar, sacral, coxygeal
What do nerves from the cervical spine lead to?
upper limbs/forelimbs
What do nerves from the thoracic spine lead to?
body wall and skin
What do nerves from the lumbar spine lead to ?
lower/hind limbs
What do nerves from the sacral spine lead to?
lower/hind limbs
Why is the cord not uniform in thickness?
increases in thickness in areas which correspond with limbs, increased neurons to the area
Where is the spinal cord thicker?
lumbar/sacral and cervical regions
What shape is the end of the spinal cord?
cone shaped
What is the name for the end of the spinal cord?
conus medullaris
At the end of the spinal cord what is the name of the nerves which continue in the vertebrae?
cauda equina
What is the filum terminale?
attachment of pia mater thread to the coccyx to anchor the spinal cord and cauda equina
what is the number of nerve pairs in each region often the same as?
the number of vertebrae in that region
How many pairs of spinal nerves are there in humans?
31
How many pairs of cervical nerves do all mammals have?
8
What happens to nerves in the thoracic region when they leave the spinal cord?
come out horizontally and don’t touch any other nerves
What are plexi?
groups of nerves that join together outside the spinal cord to form bigger nerves
What are 3 plexi in the mammalian body?
brachial plexus, lumbar plexus, sacral plexus
What do cranial nerves form part of?
PNS
How many pairs of cranial nerves are there?
12
Where do most cranial nerves originate from?
midbrain
What arteries make up the circle of willis?
clockwise from rostral end: anterior communicating artery, anterior cerebral artery, posterior communicating artery, posterior cerebral artery
Why is the circle of willis so important?
collateral blood flow, if one artery becomes blocked the blood can still flow to the brain
What are venous sinuses?
channels of venous blood that run between layers of dura
What two layers of dura are venous sinuses found between?
periostial and meningial
Where is the superior saggital sinus located?
over the top of the brain, on the midline
What does the sigmoid sinus do?
drains all blood from transverse sinus into internal jugular vein
What are the ventricles of the brain?
chambers within the brain
What do ventricles in the brain produce?
CSF
What are the 4 ventricles of the brain?
2 lateral ventricles that drain in to the 3rd ventricle in the midline, 4th ventricle is in the hindbrain
Where does cerebral spinal fluid enter the spinal cord and sub arachnoid space?
lateral and median apatures
What is CSF produced by that is found within all the ventricles of the brain?
choroid plexus
Where is CSF absorbed back into the blood stream?
venous sinuses at arachnoid villi
What does the ectoderm in an embryo go on to create?
skin and nervous system
What does ectoderm differentiate into?
ectoderm (skin) and neuroectoderm (neural tube)
What are neural crests the margins of?
neuroectoderm
What happens when neural crests meet in the mid line?
form a tube (neural tube)
What happens to neural crest cells once they separate from neuroectoderm?
migrate across embryo to differentiate into multiple different neural cells
What 7 structures do neural crest cells differentiate into?
sympathetic ganglia dorsal root ganglion (neural tube) adrenal medulla intrinsic nerve plexuses ondontoblasts melanocytes tissues of iris
What are the edges of the neural plate called?
neural folds
What do neural folds meet in the midline to form?
neural tube
what are the holes at each end of the neural tube known as?
cranial or caudal neuropores
Once the neuropores are closed what structures can begin to form?
brain and spinal cord
What does the closed neural tube then undergo to form the 3 cranial vesicles?
massive growth, swelling and folding
How many cranial vesicles are there initially?
3
What are the names of the 3 vesicles?
forebrain, midbrain and hindbrain
What does the lumen of the neural tube form?
ventricles of brain
At what week are 5 cranial vesicles formed?
week 5
What is the correct term for the forebrain?
prosencephalon
what is the correct term for the midbrain?
mesencephalon
what is the correct term for the hindbrain?
rhombencephalon
What are the names of the vesicles that the prosencephalon splits into?
telencephalon and diencephalon
What is formed in the telencephalon?
cerebral hemispheres and lateral ventricles
what is formed in the diencephalon?
thalamus, hypothalamus, pituitary gland and the 3rd ventricle
what two ventricles form in the rhombencephalon?
metencephalon and myelencephalon
what is formed in the metencephalon?
pons and cerebellum
what is formed in the myelencephalon?
medulla oblongata
from which vesicle does the optic vesicle originate?
diencephalon
What happens to the lumen of the mesencephalon?
narrows to form cerebral aqueduct
How many different fibre types are there in the brain?
3
How are the fibre types in the brain named?
According to their origin and destination