Nephrology Flashcards
Chronic Renal Disease
- F > M
- more likely to progress to renal failure in men
- 35% of adult diabetics
- 20% of adults with hypertension
- usually irreversible and progressive end-stage renal disease
Clinical Symptoms of Chronic Renal Disease
- initially asymptomatic until GFR < 25%
- uremia
- thrombocytopenia–>purpura
- diminished thromboxane–>impaired thrombin formation
- elevated prostacyclin–>poor platelet aggregation
- defective von Willebrand factor
- hypertension
- anemia
- defective phagocyte function–>infection
- renal osteodystrophy
Renal Osteodystrophy
- phosphate retention
- calcium excretion
- increased PTH (secondary hyperparathyroidism)
- giant cell lesions of the bone
Management of Chronic Renal Disease
- control blood pressure
- treat infection
- restrict potassium
- CV risk-reduction strategies
- replenish iron stores
- inhibit bone resorption
* *reduce PTH/bisphosphonates - avoid renally-cleared/nephrotic drugs
Dental Aspects-Hemodialysis
- periodontal disease is COMMON
- dental tx best done the day AFTER dialysis
- bleeding tendency due to heparinization
- oral infection–>septicemia
- hyposalivation
- mucosal ulceration
- NO general anesthesia
- uremic stomatitis, metallic taste, loss of lamina dura, osteoporosis, giant cell lesions of bone
Uremic Stomatitis
- patient’s breath may smell like ammonia
2. white lesions
Nephrotic Syndrome
- glomerular damage–>proteinuria–>hypoalbuminemia–>edema
- face, genital, lower limb edema
- ascites
- loss of immunoglobuilns–>infection
- increased clotting factors–>hypercoagulability
- Vitamin D deficiency–>renal osteodystrophy
Management of Nephrotic Syndrome
- reduce proteinuria
- control infections
- prevent thromboembolism
- corticosteroids, low salt/high protein diet, Warfarin, prophylactic antimicobials
Nephrotic Syndrome-Dental Aspects
- long-term corticosteroid side effects
2. consider antibiotic prophylaxis
Nephrolithiasis (Kidney Stones)
- VERY common
- usually visible radiographically
- no consistent relationship to underlying systemic disease
- no relationship to dental calculus or salivary stones
- if not spontaneously passed, treated with lithotripsy or surgical removal
Renal Cancer
- 90% are adenocarinomas (malignancy of glandular tissue)
- hematuria is often the initial symptom
- treated with nephrectomy
- may metastasize to the jaws
Renal Transplantation
- treatment of choice for ESRD
- 90% one-year graft survival
- 70% five-year graft survival
- life-long immunosuppresion (increased oral infection risk, gingival hyperplasia, oral ulceration)
Cyclosporine and Nifedipine
- sometimes given to patients to help with immunosuppression after a kidney transplant
- may lead to gingival hyperplasia
- improved oral hygiene can help offset the gingival hyperplasia
Acute Renal Failure
- Pre-renal factors (55%)
* *hypotension
* *thrombosis
* *sepsis
* *dehydration
* *heat stroke
* *drugs - Post-renal factors
* *obstructed urine flow
Chronic Renal Disease - Anatomical Classification
- vascular
- glomerular
- tubulointerstitial
- obstructive
Chronic Renal Disease - Etiology
- diabetes
- hypertension
- glomerulonephritis
Females/men are more likely to get chronic renal disease
Females
Females/men are more likely to progress form chronic renal disease to renal failure
Men
Renal cancer may metastasize to the __ (body part)
Jaws
The first sign of renal cancer is __ (symptom)
Hematuria
Renal osteodystrophy is characterized by phosphate retention/secretion and calcium retention/secretion
phosphate retention
calcium secretion
Renal osteodystrophy is characterized by increased/decreased PTH
increased PTH
Chronic renal disease affects __ (percent) of adult diabetics
35%
Chronic renal disease affects __ (percent) of adults with hypertension
20%
Initially asymptomatic until GFR < 25%
Chronic Renal Disease
Uremia
Chronic Renal Disease
Thrombocytopenia–>purpura
Chronic Renal Disease
Diminished thromboxane–>impaired thrombin formation
Chronic Renal Disease
Elevated prostacylcin–>poor platelet aggregation
Chronic Renal Disease
Defective von Willebrand factor
Chronic Renal Disease
Hypertension
Chronic Renal Disease
Anemia
Chronic Renal Disease
Defective phagocyte function–>infection
Chronic Renal Disease
Giant cell lesions of the bone
Renal osteodystrophy
Glomerular damage
Nephrotic syndrome
Face, genital, lower limb edema
Nephrotic syndrome
Ascites
Nephrotic syndrome
Loss of immunoglobulins/infection
Nephrotic syndrome
Increased clotting factors/hyper-coagulability
Nephrotic syndrome
Vitamin D deficiency/renal osteodystrophy
Nephrotic syndrome
Proteinuria/hypoalbuminemia
Nephrotic syndrome
__ (percent) of renal cancers are adenocarcinomas
90%
Gingival hyperplasia
Cyclosporine and Nifedipine