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Summer 2017-Oral Medicine Final > Autoimmune Disease > Flashcards

Autoimmune Disease Flashcards

1
Q

Autoimmune Disease

A
  1. F&raquo_space; M
  2. middle-age
  3. positive family history
  4. multiple co-existent autoimmune diseases
    * *Raynaud disease
    * *Sjogren syndrome
  5. multiple auto-antibodies
  6. respond to immunosuppresive therapy
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2
Q

Raynaud Disease/Phenomenon

A
  1. W > M
  2. recurrent vasospasm of fingers and toes
  3. response to stress/cold
  4. tissue: white–>blue–>red
  5. primary–only Raynaud
  6. Secondary–Raynaud and another AI disorder
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3
Q

Consequences of Raynaud Disease

A
  1. tissue may die from repeated vascular injury
  2. very painful
  3. wear gloves all the time
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4
Q

Systemic Lupus

A
  1. F > M
  2. butterfly rash uncommon
  3. photosensitivity rash common (sensitive to sun)
  4. renal involvement with hypertension
  5. cardiac lesions (Libman-Sacks endocarditis)
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5
Q

Systemic Lupus-Dental Aspects

A
  1. mucosal lesions are indistinguishable from lichen planus

2. slit-like ulcers at gingival margin?

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6
Q

Drug-Induced Lupus

A
  1. resembles systemic lupus erythematosus

2. resolves when drug is discontinued

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7
Q

Discoid Lupus

A
  1. mucotaneous disease
  2. indistinguishable from systemic lupus
  3. serologic abnormalities minimal or absent
  4. no serious systemic effects
  5. rare progression to systemic lupus
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8
Q

Discoid Lupus-Clinical Features

A
  1. facial/sun-exposed skin rash
  2. scalp alopecia
  3. mucosal lesions
  4. respond to corticosteroids
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9
Q

Discoid Lupus - Dental Aspects

A
  1. mimic lichen planus
  2. biopsy essential
  3. malignant potential ?
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10
Q

Sjogren Syndrome

A
  1. F&raquo_space; M (5% of women; 0.5% of men)

2. middle-age

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11
Q

Primary Sjogren Syndrome

A
  1. dry mouth

2. dry eyes

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12
Q

Secondary Sjogren Syndrome

A
  1. dry mouth
  2. dry eyes
  3. Rheumatoid Arthritis or other CT DZ
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13
Q

What increased risk do people with Sjogren Syndrome have?

A
  1. lymphoma (MALT lymphoma)

2. usually parotid

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14
Q

Sjogren Syndrome - Diagnosis

A
  1. Serology
  2. Schirmer test (lacrimation)
  3. minor salivary gland biopsy (immune destruction)
  4. salivary flow rate/production
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15
Q

Sjogren Syndrome - Dental Aspects

A
  1. mucosal discomfort
  2. candidiasis
  3. parotid enlargement
  4. dysphagia, dysphonia, dysgeusiz
  5. difficulty wearing dentures
  6. symptomatic tx
  7. preventive care
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16
Q

Scleroderma

A
  1. hard skin
  2. localized - morphea
  3. linerar - coup de sabre
  4. systemic
    * *limited
    * *diffuse
    * *sine
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17
Q

Graulomatosis with Polyangiitis

A

1, AKA Wegener granulomatosis

  1. giant cell vasculitis w/ necrotizing respiratory granulomas
    * *nasopharyngeal inflammation
    * *pulmonary cavitation
    * *renal disease
  2. erythematous, swollen gingiva with strawberry-like texture
  3. mucosal ulceration
  4. delayed extraction socket healing
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18
Q

Scleroderma - Dental Aspects

A
  1. 80% with head and neck symptoms
  2. 30% are initial signs and symptoms
  3. mask-like face (Mona Lisa)
  4. restricted facial movements
  5. constricted mouth opening (fish mouth)
  6. limited tongue mobility (chicken tongue)
  7. jaw resorption
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19
Q

Urticarial plaques forming blisters, oral lesions

A

Linear IgA Disease

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20
Q

Autoimmune diseases are more common in __ (age)

A

middle age

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21
Q

Positive family history

A

Autoimmune disease

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22
Q

Recurrent vasospasm of fingers and toes

A

Raynaud Disease

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23
Q

Response to stress/cold

A

Raynaud Disease

24
Q

NO butterfly rash

A

Systemic Lupus

25
Photosensitivity rash common (sensitive to sun)
Systemic Lupus, Discoid Lupus
26
Renal involvement and hypertension
Systemic Lupus
27
Cardiac lesions (Libman-Sacks endocarditis)
Systemic Lupus
28
Mucosal lesions mimic lichen planus
Systemic Lupus, Discoid Lupus
29
Resembles systemic lupus erythematosus
Drug-Induced Lupus
30
Mucocutaneous Disease
Discoid Lupus
31
Indistiguishable from systemic lupus
Discoid Lupus
32
Serological abnormalities minimal/absent
Discoid Lupus
33
Scalp alopecia
Discoid Lupus
34
Responds to corticosteroids
Discoid Lupus
35
Schirmer test
Sjogren syndrome
36
Mucosal discomfort
Sjogren syndrome
37
Candidiasis
Sjogren syndrome
38
Parotid enlargment
Sjogren syndrome
39
Dysphagia, dysphonia, dysgeuiz
Sjogren syndrome
40
Difficulty wearing dentures
Sjogren syndrome
41
Hard skin
scleroderma
42
Wegener granulomatosis
Granulomatosis with polyangitis
43
Giant cell vasculitis w/ necrotizing respiratory granulomas
Granulomatosis with polyangitis
44
Erythematous, swollen gingiva with strawberry-like texture
Granulomatosis with polyangitis
45
Mucosal ulceration
Granulomatosis with polyangitis
46
Delayed extraction socket healing
Granulomatosis with polyangitis
47
80% with head and neck symptoms
Scleroderma
48
Mask-like Mona Lisa face
Scleroderma
49
Restricted facial movements
Scleroderma
50
Constricted mouth opening (fish mouth)
Scleroderma
51
Limited tongue mobility (chicken tongue)
Scleroderma
52
Jaw resorption
Scleroderma
53
Urticarial plaques forming blisters, oral lesions
Linear IgA Disease
54
Capillary malformation (port-wine stain)
Sturge-Weber Syndrome
55
Distribution of V1
Sturge-Weber Syndrome
56
Soft tissue overgrowth
Sturge-Weber Syndrome

Summer 2017-Oral Medicine Final (17 decks)

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