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Summer 2017-Oral Medicine Final > Autoimmune Disease > Flashcards

Autoimmune Disease Flashcards

1
Q

Autoimmune Disease

A
  1. F&raquo_space; M
  2. middle-age
  3. positive family history
  4. multiple co-existent autoimmune diseases
    * *Raynaud disease
    * *Sjogren syndrome
  5. multiple auto-antibodies
  6. respond to immunosuppresive therapy
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2
Q

Raynaud Disease/Phenomenon

A
  1. W > M
  2. recurrent vasospasm of fingers and toes
  3. response to stress/cold
  4. tissue: white–>blue–>red
  5. primary–only Raynaud
  6. Secondary–Raynaud and another AI disorder
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3
Q

Consequences of Raynaud Disease

A
  1. tissue may die from repeated vascular injury
  2. very painful
  3. wear gloves all the time
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4
Q

Systemic Lupus

A
  1. F > M
  2. butterfly rash uncommon
  3. photosensitivity rash common (sensitive to sun)
  4. renal involvement with hypertension
  5. cardiac lesions (Libman-Sacks endocarditis)
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5
Q

Systemic Lupus-Dental Aspects

A
  1. mucosal lesions are indistinguishable from lichen planus

2. slit-like ulcers at gingival margin?

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6
Q

Drug-Induced Lupus

A
  1. resembles systemic lupus erythematosus

2. resolves when drug is discontinued

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7
Q

Discoid Lupus

A
  1. mucotaneous disease
  2. indistinguishable from systemic lupus
  3. serologic abnormalities minimal or absent
  4. no serious systemic effects
  5. rare progression to systemic lupus
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8
Q

Discoid Lupus-Clinical Features

A
  1. facial/sun-exposed skin rash
  2. scalp alopecia
  3. mucosal lesions
  4. respond to corticosteroids
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9
Q

Discoid Lupus - Dental Aspects

A
  1. mimic lichen planus
  2. biopsy essential
  3. malignant potential ?
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10
Q

Sjogren Syndrome

A
  1. F&raquo_space; M (5% of women; 0.5% of men)

2. middle-age

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11
Q

Primary Sjogren Syndrome

A
  1. dry mouth

2. dry eyes

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12
Q

Secondary Sjogren Syndrome

A
  1. dry mouth
  2. dry eyes
  3. Rheumatoid Arthritis or other CT DZ
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13
Q

What increased risk do people with Sjogren Syndrome have?

A
  1. lymphoma (MALT lymphoma)

2. usually parotid

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14
Q

Sjogren Syndrome - Diagnosis

A
  1. Serology
  2. Schirmer test (lacrimation)
  3. minor salivary gland biopsy (immune destruction)
  4. salivary flow rate/production
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15
Q

Sjogren Syndrome - Dental Aspects

A
  1. mucosal discomfort
  2. candidiasis
  3. parotid enlargement
  4. dysphagia, dysphonia, dysgeusiz
  5. difficulty wearing dentures
  6. symptomatic tx
  7. preventive care
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16
Q

Scleroderma

A
  1. hard skin
  2. localized - morphea
  3. linerar - coup de sabre
  4. systemic
    * *limited
    * *diffuse
    * *sine
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17
Q

Graulomatosis with Polyangiitis

A

1, AKA Wegener granulomatosis

  1. giant cell vasculitis w/ necrotizing respiratory granulomas
    * *nasopharyngeal inflammation
    * *pulmonary cavitation
    * *renal disease
  2. erythematous, swollen gingiva with strawberry-like texture
  3. mucosal ulceration
  4. delayed extraction socket healing
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18
Q

Scleroderma - Dental Aspects

A
  1. 80% with head and neck symptoms
  2. 30% are initial signs and symptoms
  3. mask-like face (Mona Lisa)
  4. restricted facial movements
  5. constricted mouth opening (fish mouth)
  6. limited tongue mobility (chicken tongue)
  7. jaw resorption
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19
Q

Urticarial plaques forming blisters, oral lesions

A

Linear IgA Disease

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20
Q

Autoimmune diseases are more common in __ (age)

A

middle age

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21
Q

Positive family history

A

Autoimmune disease

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22
Q

Recurrent vasospasm of fingers and toes

A

Raynaud Disease

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23
Q

Response to stress/cold

A

Raynaud Disease

24
Q

NO butterfly rash

A

Systemic Lupus

25
Q

Photosensitivity rash common (sensitive to sun)

A

Systemic Lupus, Discoid Lupus

26
Q

Renal involvement and hypertension

A

Systemic Lupus

27
Q

Cardiac lesions (Libman-Sacks endocarditis)

A

Systemic Lupus

28
Q

Mucosal lesions mimic lichen planus

A

Systemic Lupus, Discoid Lupus

29
Q

Resembles systemic lupus erythematosus

A

Drug-Induced Lupus

30
Q

Mucocutaneous Disease

A

Discoid Lupus

31
Q

Indistiguishable from systemic lupus

A

Discoid Lupus

32
Q

Serological abnormalities minimal/absent

A

Discoid Lupus

33
Q

Scalp alopecia

A

Discoid Lupus

34
Q

Responds to corticosteroids

A

Discoid Lupus

35
Q

Schirmer test

A

Sjogren syndrome

36
Q

Mucosal discomfort

A

Sjogren syndrome

37
Q

Candidiasis

A

Sjogren syndrome

38
Q

Parotid enlargment

A

Sjogren syndrome

39
Q

Dysphagia, dysphonia, dysgeuiz

A

Sjogren syndrome

40
Q

Difficulty wearing dentures

A

Sjogren syndrome

41
Q

Hard skin

A

scleroderma

42
Q

Wegener granulomatosis

A

Granulomatosis with polyangitis

43
Q

Giant cell vasculitis w/ necrotizing respiratory granulomas

A

Granulomatosis with polyangitis

44
Q

Erythematous, swollen gingiva with strawberry-like texture

A

Granulomatosis with polyangitis

45
Q

Mucosal ulceration

A

Granulomatosis with polyangitis

46
Q

Delayed extraction socket healing

A

Granulomatosis with polyangitis

47
Q

80% with head and neck symptoms

A

Scleroderma

48
Q

Mask-like Mona Lisa face

A

Scleroderma

49
Q

Restricted facial movements

A

Scleroderma

50
Q

Constricted mouth opening (fish mouth)

A

Scleroderma

51
Q

Limited tongue mobility (chicken tongue)

A

Scleroderma

52
Q

Jaw resorption

A

Scleroderma

53
Q

Urticarial plaques forming blisters, oral lesions

A

Linear IgA Disease

54
Q

Capillary malformation (port-wine stain)

A

Sturge-Weber Syndrome

55
Q

Distribution of V1

A

Sturge-Weber Syndrome

56
Q

Soft tissue overgrowth

A

Sturge-Weber Syndrome

Summer 2017-Oral Medicine Final (17 decks)

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