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Summer 2017-Oral Medicine Final > Immunity, Inflammatory Disorders, Immunosuppressive, and Anti-Inflammatory Agents > Flashcards

Immunity, Inflammatory Disorders, Immunosuppressive, and Anti-Inflammatory Agents Flashcards

1
Q

Innate Immunity

A
  1. soluble factors (complement and cytokines)
  2. recruit neutrophils and macrophages
  3. destroy microbes
  4. complement
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2
Q

Interferons

A

viral infections

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3
Q

Tumor necrosis factors

A

malignancy

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4
Q

Transforming growth factors

A

wound healing

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5
Q

Interleukins

A

multiple functions

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6
Q

chemokines

A

chemoattractants

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7
Q

Colony-stimulating factors

A

hemopoietic cell differentiation

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8
Q

Acute Phase Reactants

A
  1. injury/infection/trauma/malignancy
  2. neutrophils and macrophages secrete cytokines
  3. liver produces acute phase reactants
  4. suppress inflammation
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9
Q

IgA

A

secretory and mucosal immunity

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10
Q

IgD

A

unknown significance

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11
Q

IgE

A

allergy and parasitic diseases

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12
Q

IgG

A

bacterial infections

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13
Q

IgM

A

opsonization

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14
Q

Cell-Mediated Immunity

A
  1. antigen-presenting cells - macrophages and langerhans cells
  2. activated T cell induce cell-mediated immunity
    * *intracellular bacteria
    * *viral infetions
    * *fungal infections
    * *graft-versus-host disease
    * *delayed type hypersensitivity reaction
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15
Q

CD4 Helper T Cells

A
  1. induce B-cell differentiation
  2. induce CD8 cytotoxic T-cell
  3. produce lymphokines
  4. regulate erythropoiesis
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16
Q

CD8 (cytoxic/suppressor) T cells

A

destroy virally infected cells

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17
Q

Evaluation of B-cell function

A
  1. measure serum IgG, IgA, IgM

2. assessment of antibody function (titers)

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18
Q

Evaluation of T-cell function

A
  1. count circulating T cells

2. delayed-type hypersensitivity skin test

19
Q

Evaluation of Phagocyte function

A
  1. CBC and differential

2. in vitro assays of chemotaxis, phagocytosis bactericial activity

20
Q

What are autoinflammatory diseases?

A
  1. imbalance between pro-inflammatory and anti-inflammatory factors
  2. begins in childhood
  3. fluctuating episodes of fever and inflammation
  4. affects skin, mucosa, eyes, and joints
21
Q

Immunosuppressive Therapy

A
  1. depress cell mediated responses: transplant recipients
  2. depress autoantibody production: autoimmune and CT diseases
  3. control immunoproliferative diseases
22
Q

__ predisposes people to infection and malignancy (especially virally-induced such as HPV, EBV, HHV-8)

A

immunosuppressive therapy

23
Q

C3a

A

inflammation

24
Q

C5a

A

chemotaxis

25
Q

C5b

A

opsonization

26
Q

C5-9

A

cell membrane lysis

27
Q

B lymphocytes

A
  1. make plasma cells

2. produce antibodies (humoral immunity)

28
Q

T lymphocytes

A

cell mediated immunity

29
Q

Neutrophils and macrophages

A

phagocytosis

30
Q

Autoinflammatory Disease - Dental Aspects

A
  1. PFAPA
    * *periodi fever
    * *aphthous stomatitis
    * *pharyngitis
    * *adenitis
  2. famiial Mediterranean fever
  3. TRAPS–>Tumor necrosis factor receptor-associated periodic syndrome
31
Q

Systemic Non-Biological Immunomodulators

A
  1. cytotoxic/increased adverse effects
    * *azathoprine–>bone marrow suppression, lymphoma
  2. calcineurin inhibitors
    * *tacrolimus–>enhance tumor development
  3. biologics
    * *produced by recombinant DNA technology
    * *reactivation of viral disease, mycobacterial disease
32
Q

induce B cell differentiation

A

CD4 Helper T cells

33
Q

induce CD8 cytotoxic T cells

A

CD4 Helper T cells

34
Q

produce lymphokines

A

CD4 Helper T cells

35
Q

regulate erythropoiesis

A

CD4 Helper T cells

36
Q

imbalance between pro-inflammatory and anti-inflammatory factors

A

autoinflammatory diseases

37
Q

autoinflammatory diseases begin in __

A

childhood

38
Q

fluctuating periods of fever and inflammation

A

autoinflammatory disease

39
Q

affects skin, mucosa, eyes, and joints

A

autoinflammatory disease

40
Q

depresses cell mediated responses

A

immunosuppressive therapy

41
Q

depresses autoantibody responses

A

immunosuppressive therapy

42
Q

controls/prevents immunoproliferative diseases

A

immunosuppressive therapy

43
Q

predisposes people to infection/malignancy

A

immunosuppressive therapy

Summer 2017-Oral Medicine Final (17 decks)

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