Immunity, Inflammatory Disorders, Immunosuppressive, and Anti-Inflammatory Agents

Question 1

Innate Immunity

Answer 1

1. soluble factors (complement and cytokines)
2. recruit neutrophils and macrophages
3. destroy microbes
4. complement

Question 2

Interferons

Answer 2

viral infections

Question 3

Tumor necrosis factors

Answer 3

malignancy

Question 4

Transforming growth factors

Answer 4

wound healing

Question 5

Interleukins

Answer 5

multiple functions

Question 6

chemokines

Answer 6

chemoattractants

Question 7

Colony-stimulating factors

Answer 7

hemopoietic cell differentiation

Question 8

Acute Phase Reactants

Answer 8

1. injury/infection/trauma/malignancy
2. neutrophils and macrophages secrete cytokines
3. liver produces acute phase reactants
4. suppress inflammation

Question 9

IgA

Answer 9

secretory and mucosal immunity

Question 10

IgD

Answer 10

unknown significance

Question 11

IgE

Answer 11

allergy and parasitic diseases

Question 12

IgG

Answer 12

bacterial infections

Question 13

IgM

Answer 13

opsonization

Question 14

Cell-Mediated Immunity

Answer 14

1. antigen-presenting cells - macrophages and langerhans cells
2. activated T cell induce cell-mediated immunity
   * *intracellular bacteria
   * *viral infetions
   * *fungal infections
   * *graft-versus-host disease
   * *delayed type hypersensitivity reaction

Question 15

CD4 Helper T Cells

Answer 15

1. induce B-cell differentiation
2. induce CD8 cytotoxic T-cell
3. produce lymphokines
4. regulate erythropoiesis

Question 16

CD8 (cytoxic/suppressor) T cells

Answer 16

destroy virally infected cells

Question 17

Evaluation of B-cell function

Answer 17

1. measure serum IgG, IgA, IgM

2. assessment of antibody function (titers)

Question 18

Evaluation of T-cell function

Answer 18

1. count circulating T cells

2. delayed-type hypersensitivity skin test

Question 19

Evaluation of Phagocyte function

Answer 19

1. CBC and differential

2. in vitro assays of chemotaxis, phagocytosis bactericial activity

Question 20

What are autoinflammatory diseases?

Answer 20

1. imbalance between pro-inflammatory and anti-inflammatory factors
2. begins in childhood
3. fluctuating episodes of fever and inflammation
4. affects skin, mucosa, eyes, and joints

Question 21

Immunosuppressive Therapy

Answer 21

1. depress cell mediated responses: transplant recipients
2. depress autoantibody production: autoimmune and CT diseases
3. control immunoproliferative diseases

Question 22

__ predisposes people to infection and malignancy (especially virally-induced such as HPV, EBV, HHV-8)

Answer 22

immunosuppressive therapy

Question 23

C3a

Answer 23

inflammation

Question 24

C5a

Answer 24

chemotaxis

Question 25

C5b

Answer 25

opsonization

Question 26

C5-9

Answer 26

cell membrane lysis

Question 27

B lymphocytes

Answer 27

1. make plasma cells | 2. produce antibodies (humoral immunity)

Question 28

T lymphocytes

Answer 28

cell mediated immunity

Question 29

Neutrophils and macrophages

Answer 29

phagocytosis

Question 30

Autoinflammatory Disease - Dental Aspects

Answer 30

1. PFAPA * *periodi fever * *aphthous stomatitis * *pharyngitis * *adenitis 2. famiial Mediterranean fever 3. TRAPS-->Tumor necrosis factor receptor-associated periodic syndrome

Question 31

Systemic Non-Biological Immunomodulators

Answer 31

1. cytotoxic/increased adverse effects * *azathoprine-->bone marrow suppression, lymphoma 2. calcineurin inhibitors * *tacrolimus-->enhance tumor development 3. biologics * *produced by recombinant DNA technology * *reactivation of viral disease, mycobacterial disease

Question 32

induce B cell differentiation

Answer 32

CD4 Helper T cells

Question 33

induce CD8 cytotoxic T cells

Answer 33

CD4 Helper T cells

Question 34

produce lymphokines

Answer 34

CD4 Helper T cells

Question 35

regulate erythropoiesis

Answer 35

CD4 Helper T cells

Question 36

imbalance between pro-inflammatory and anti-inflammatory factors

Answer 36

autoinflammatory diseases

Question 37

autoinflammatory diseases begin in __

Answer 37

childhood

Question 38

fluctuating periods of fever and inflammation

Answer 38

autoinflammatory disease

Question 39

affects skin, mucosa, eyes, and joints

Answer 39

autoinflammatory disease

Question 40

depresses cell mediated responses

Answer 40

immunosuppressive therapy

Question 41

depresses autoantibody responses

Answer 41

immunosuppressive therapy

Question 42

controls/prevents immunoproliferative diseases

Answer 42

immunosuppressive therapy

Question 43

predisposes people to infection/malignancy

Answer 43

immunosuppressive therapy