Materials and Drugs Flashcards
Chlorhexidine Allergy
- rare allergy
- antiseptic/disinfectant
- treat like latex allergy
Metal allergies
- gold alloys: rare
- mercury amalgam: silver, tin, copper, zinc–>Lichenoid rxn
- Nickel: nickel titanium orthodontic wire, jewelry
- titanium: rare
Dental cement allergies are rare/common
rare
- zinc phosphate
- zinc oxide and eugenol
- polycaroxylate
- glass ionomer
Bis-phenol A allergy in dental sealants and composites
- in vitro estrogenic activity
- obesity, diabetes, cardiovascular disease, polycystic ovaries, low sperm count
- SMALL amount of leaching compared to plastic bottles and can liners
- NO basis for dental concern
Zinc in Polygrip and Fixodent
- absorption potentially causes copper deficiency
- can lead to myelopathy and polyneuropathy WHEN NOT USED IN ACCORDING TO MANUFACTURER’S DIRECTIONS
- Sln - reformulate products to “zinc free”
__ is the level of water fluoridation in WI
0.7 ppm
Fluoridation
No relationship to
- bladder cancer or osteosarcoma
- bone strength, mineral density, bone fracture
Mercury
high levels are neurotoxic and nephrotoxic
__ mercury poisoning is the most common
organic
ex: industrial pollution gets into fish
Inorganic mercury salt poisoning is rare/common
rare
- acrodynia: exfoliation, hypersalivation, muscular, hypotonia, peripheral edema
- GI ulceration, necrosis
- renal failure
Metallic mercury
- neurotoxic and nephrotic
- mining
- santeria - Carribean religious practice
- accidents
- suicide
Acute Mercury Toxicity
rare
- penumonitis
- CNS symptoms (tremors, excitability)
Chronic mercury toxicity
rare
- tremor
- incoordination
- polyneuropathies
- senility
- anorexia
- weight loss
- accelerated periodontal disease, gingival pigmentation
Mercury Hygiene
- no hand trituration of amalgam
- no carpeting in dental operatories
- no handling of amalgam scraps
- common sense
Amalgam emits mercury vapor when __
- chewing
- eating
- tooth brushing
- drinking hot liquids
- H2O2
- amalgam removal
__ (states) have statuatory informed consent for amalgam
- CA
- CT
- ME
- VT
Amalgam is illegal in __ (country)
Scandinavia
Mercury disposal
- amalgam separators (95% effective)
2. amalgam disposal
Water tx plants are __ (percent) effective in removing mercury
90%
OTC tooth-whitening
- trays (10% carbamide peroxide containing 3% H2O2)
- paint-on (3-10% H2O2(
- strips (6% H2O2)
Dentrifices
- contact dermatitis
- contact mucositis
* *cinnamon flavored products
* *plasma cell gingivitis
* *tartar-control dentrifices with cinnamon or pyrophosphates - orofacial granulomatosis
* *zirconium
Pediatric patients need higher/lower drug dosages than adults
lower
Most drug allergies/hypersensitivities are __ (antibody) mediated
IgE
Drug Allergy Diagnosis
- clinical: rash or anaphylaxis
2. lab: skin testing
Drug Allergy Tx
- discontinue drug
2. pt education
Adverse effects with IV anesthetics
anaphylaxis
Adverse effects with analgesics
- aspirin: platelet dysfunction
2. acetaminophen: liver dysfunction
Adverse effects with anti-convulsants
- usually skin eruptions
2. potentially fatal
Iodinated IV Contrast Media
- 5-8% of patients
- 1% of IgE-mediated urticaria/nausea/vomiting
- 0.1% anaphylaxis
How to avoid negative drug interactions
- avoid polypharmacy
- only use drugs you are familiar with
- get a consult with an MD
- be VERY careful
* *general anesthesia
* *geriatric patients
* *poor historians
Anticholinergic drugs cause __
hyposalivation
Chemotherapy drugs cause __
oral ulcers
Corticosteroids and antibiotics cause __
candidiasis
Phenytoin, cyclosporin, and calcium channel blockers cause __
gingival hyperplasia
Contact allergy to cosmetics or food causes __
chelitis
Halitosis is caused by __
- multiple drugs
2. xerostomia
Movement disorders can be caused by __
anti-psychotics
Neoplasms can be caused by __
long-term corticosteroids
Stomatodynia/dysesthesia can be caused by __
HTN medications
Pigmentation can be caused by __
- bismuth
- chlorhexidine
- amalgam
- metal crown copings
- heavy metals
- anti-malarials
- anti-psychotics
- anti-convulsants
- antibiotics
Anticholinergics can cause __
sialorrhea
Gingival enlargement can be caused by __
- phenytoin
- cyclosporine
- calcium channel blockers
Swelling in the lips/floor of mouth can be caused by __
Type 1 hypersensitivity reactions
Angioedema can be caused by __
- penicillins
- ACE inhibitors
- aspirin
Hypogeusia
loss of taste acuity
Dysgeusia
distortion of taste function
Ulceration
- misapplication of products: aspirin, tooth-ache drops, K+ tabs, H2O2
- chemotherapy drugs - MTX, 5-FU
- NSAIDs, beta blockers, bisphosphonates
Xerostomia can be caused by __
- smoking
- alcohol
- drugs