Nephritic Syndrome (20-3) Flashcards
Nephritic Syndrome includes _____ in the glomeruli
Inflammation
What are the 4 signs of Nephritic Syndrome?
- Proteinuria < 3.5 g/day
- Hematuria
- New onset HTN
- Azotemia
What are the 4 signs of Nephritic Syndrome?
- Proteinuria < 3.5 g/day
- Hematuria
- New onset HTN
- Azotemia
All of the diseases discussed in this deck can cause?
Nephritic Syndrome and/or Rapidly Progressive Glomerulonephritis
Post-Infectious Glomerulonephritis is most commonly due to infections with what bacteria and where and in who?
Streptococci of the pharynx/skin in children
What types of streptococci are the most common causes of Post-Infectious Glomerulonephritis?
Group A beta-hemolytic types 12, 4, 1
Post-Infectious Glomerulonephritis involves the proliferation of glomerular cells with leukocyte influx. Where do these complexes deposit?
Subepithelial humps
How does Post-Infectious Glomerulonephritis look on immunofluorescence?
Granular
– in situ immune complex formation
What occurs with Rapidly Progressive Glomerulonephritis (RPGN)?
Rapid loss of renal function
- -> oliguria and nephritic syndrome signs
- -> renal failure
What is a hallmark of RPGN?
Crescents in the glomeruli
– epithelial cells + leukocytes
What is 1 Anti-GBM antibody disease that can cause RPGN/Nephritic Syndrome?
Goodpasture Syndrome
What are the symptoms of Goodpasture Syndrome and in what patients?
Pulmonary hemorrhage + renal failure in young men
How will Goodpasture Syndrome appear on immunofluorescence?
Linear
– Anti-GBM antibodies
Goodpasture syndrome involves Anti-GBM antibodies that are specific to what portion?
Non-collagenous alpha 3 unit of collagen 4
What are the 3 immune complex deposition diseases that can cause RPGN/Nephritic Syndrome?
- Lupus Nephritis
- Henoch-Schonlein Purpura
- IgA Nephropathy
What are the 3 immune complex deposition diseases that can cause RPGN/Nephritic syndrome?
- Lupus Nephritis
- Henoch-schonlein purpura
- IgA Nephropathy
What antibodies classify Lupus Nephritis type IV?
Anti-dsDNA
Anti-smith
What is a hallmark of Lupus Nephritis?
Wire loop
= subendothelial deposits that cause circumferential thickening of capillary wall
What is a hallmark of Lupus Nephritis?
Wire loop
= subendothelial deposits that cause circumferential thickening of capillary wall
What population of people are usually affected by Henoch-schonlein purpura?
Children
What are the symptoms in children with Henoch-Schonlein Purpura?
Purpura of the legs, arms, butt
Abdominal pain and GI bleed
Athralgias and renal abnormalities
What are the symptoms in children with Henoch-Schonlein Purpura?
Purpura of the legs, arm, butt
Abdominal pain with GI bleed
Athralgias and renal abnormalities
If Henoch-schonlein purpura presents in adults, what symptoms will be more severe?
Renal symptoms
With Henoch-Schonlein purpura, what does the child of a background of and a history of?
Background of atopy
History of recent URI
