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2 - CPR (renal) > Nephritic Syndrome (20-3) > Flashcards

Nephritic Syndrome (20-3) Flashcards

1
Q

Nephritic Syndrome includes _____ in the glomeruli

A

Inflammation

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2
Q

What are the 4 signs of Nephritic Syndrome?

A
  1. Proteinuria < 3.5 g/day
  2. Hematuria
  3. New onset HTN
  4. Azotemia
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3
Q

What are the 4 signs of Nephritic Syndrome?

A
  1. Proteinuria < 3.5 g/day
  2. Hematuria
  3. New onset HTN
  4. Azotemia
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4
Q

All of the diseases discussed in this deck can cause?

A

Nephritic Syndrome and/or Rapidly Progressive Glomerulonephritis

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5
Q

Post-Infectious Glomerulonephritis is most commonly due to infections with what bacteria and where and in who?

A

Streptococci of the pharynx/skin in children

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6
Q

What types of streptococci are the most common causes of Post-Infectious Glomerulonephritis?

A

Group A beta-hemolytic types 12, 4, 1

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7
Q

Post-Infectious Glomerulonephritis involves the proliferation of glomerular cells with leukocyte influx. Where do these complexes deposit?

A

Subepithelial humps

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8
Q

How does Post-Infectious Glomerulonephritis look on immunofluorescence?

A

Granular

– in situ immune complex formation

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9
Q

What occurs with Rapidly Progressive Glomerulonephritis (RPGN)?

A

Rapid loss of renal function

  • -> oliguria and nephritic syndrome signs
  • -> renal failure
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10
Q

What is a hallmark of RPGN?

A

Crescents in the glomeruli

– epithelial cells + leukocytes

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11
Q

What is 1 Anti-GBM antibody disease that can cause RPGN/Nephritic Syndrome?

A

Goodpasture Syndrome

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12
Q

What are the symptoms of Goodpasture Syndrome and in what patients?

A

Pulmonary hemorrhage + renal failure in young men

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13
Q

How will Goodpasture Syndrome appear on immunofluorescence?

A

Linear

– Anti-GBM antibodies

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14
Q

Goodpasture syndrome involves Anti-GBM antibodies that are specific to what portion?

A

Non-collagenous alpha 3 unit of collagen 4

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15
Q

What are the 3 immune complex deposition diseases that can cause RPGN/Nephritic Syndrome?

A
  1. Lupus Nephritis
  2. Henoch-Schonlein Purpura
  3. IgA Nephropathy
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16
Q

What are the 3 immune complex deposition diseases that can cause RPGN/Nephritic syndrome?

A
  1. Lupus Nephritis
  2. Henoch-schonlein purpura
  3. IgA Nephropathy
17
Q

What antibodies classify Lupus Nephritis type IV?

A

Anti-dsDNA

Anti-smith

18
Q

What is a hallmark of Lupus Nephritis?

A

Wire loop

= subendothelial deposits that cause circumferential thickening of capillary wall

19
Q

What is a hallmark of Lupus Nephritis?

A

Wire loop

= subendothelial deposits that cause circumferential thickening of capillary wall

20
Q

What population of people are usually affected by Henoch-schonlein purpura?

A

Children

21
Q

What are the symptoms in children with Henoch-Schonlein Purpura?

A

Purpura of the legs, arms, butt
Abdominal pain and GI bleed
Athralgias and renal abnormalities

22
Q

What are the symptoms in children with Henoch-Schonlein Purpura?

A

Purpura of the legs, arm, butt
Abdominal pain with GI bleed
Athralgias and renal abnormalities

23
Q

If Henoch-schonlein purpura presents in adults, what symptoms will be more severe?

A

Renal symptoms

24
Q

With Henoch-Schonlein purpura, what does the child of a background of and a history of?

A

Background of atopy

History of recent URI

25
Q

What is hallmark of Henoch-Schonlein purpuar?

A

IgA deposits in Mesangium

26
Q

IgA deposits in the mesangium could indicate what 2 immune complex deposition diseases?

A

Henoch-Schonlein Purpura

IgA Nephropathy

27
Q

IgA nephropathy is the most common cause of Nephritic syndrome/RPGN. Where will IgA be deposited?

A

Mesangium

28
Q

What is a recurrent symptom of IgA Nephropathy?

A

Recurrent hematuria

29
Q

What types of diseases can IgA nephropathy present with?

A

Celiac disease
Liver disease
Abnormal IgA synthesis

30
Q

Besides IgA deposits in the mesangium with IgA nephropathy, what else will be deposited?

A

C3

Properdin

31
Q

What is a Pauci-Immune cause of Nephritic Syndrome/RPGN?

A

Granulomatosis with Polyangiitis

32
Q

What marker will be (+) with Granulomatosis with Polyangiitis?

A

PR3 - ANCA

33
Q

What usually causes Granulomatosis with Polyangiitis?

A

T cell hypersensitivity to an inhaled antigen

34
Q

What are the general symptoms of Granulomatosis with Polyangiitis?

A

Granulomas and vasculitis of the respiratory tract

35
Q

What is RPGN?

A

Rapid loss of renal function

  • -> oliguria and signs of nephritic syndrome
  • -> renal failure

2 - CPR (renal) (27 decks)

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