Neoplasia VI Flashcards
uv radiation via pyrimidine dimers –> DNA damage and NER pathway
skin cancer
those with enzyme defects in NER pathway are highly susceptible (xeroderma pigmentosum)
ionizing radiation
chromosome breakage, translocation and pt mutation
atomic bomb
leukemia (except CLL)
thyroid cancer
x ray workers
radiatin dermatitis and skin canceres
dials of watches with radium
osteosarcoma
hepatitis B virus –> hepatocellular carcinoma
chronic liver cell injury arnd regenrative hyperplasia
also HBx prtn with activates growth promoting genes and binds p53
hepatitis C virus –> hepatocellular carcinoma
chronic liver cell injury and regeneration
burkitt lymphoma
hodgkin lymphoma
Bcell lymphoma in immunosuppressed
nasopharyngeal carcinoma
EBV
high risk HPV
16,18,31 viral dna integrates into host genome
E6 HPV gene
inhibits p53
E7 HPV gene
inhibits Rb
HTLV-1 human t cell leukemia virus type 1
Cd4 tropism
Tax gnes which activates cFos IL2 GM-CSF and inactivates p16INK4a
stimualtes trx of viral mRNA
HIV –>
lymphoma
HHV8
kaposi sarcoma
helicobater pylori
gastric MALT lymphomas and gastric carcinoma
via CagA gnee stimulating growth factor pathway
estrogen hormonal carcinogenesis
breat cnacer
quamous cell carcinoma of cervic
leiomyoma of uterus
contraceptive hormones
breast cnacer
beinign/malignant liver tumors
anabolic steroids
benign/malignant liver tumors
loss of body fat wasteing and profound weakness
cancer cachexia ——- associated with TNF