Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pathology II > Neoplasia II > Flashcards

Neoplasia II Flashcards

1
Q

limitless replicative potentail

A

neoplasms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

limited replicative potential

A

normal tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

loss of contact inhibition

A

neoplasm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

neoplastic cells remain in the …

A

cell cycle

higher percentage of cells in the cell cycle correlates with malignancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

clincally detectable mass

A

30 doublings- I g

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

max compatible with life

A

30 + 10 more doublings- 1 kg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

when is a tumor growth fraction highest

A

during earlier stages

it is growing rapidly at this time

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

indicators of proliferation

A

ki-67

PCNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

PCNA

A

marker for cell proliferation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

ki-67

A

marker for cell proliferation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

how do you figure mitotic activity

A

county number of mitotic figures at 10 high powre

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

fragmentation of the nuclear chromatin

A

apoptotic body

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

condensation of the nucelar chromatin

A

apoptotoic body

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is the clinical significance of difference in growth rate of tumors?

A

cells within the cell cycle are susceptible to chemo and radiotherapy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

highly susceptible to chemotherapy

A

cancers with rapid growth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

benign tumor differentiation

A

always differentiated

17
Q

malignant tumor differentiation

A

less differntiation

because within cell cycle

18
Q

complete lack of differentiation

A

anaplasia

hallmark of high grade malignant tumor

19
Q

resembles normal thyroid but forms an encapsulated thyroid mass

A

thyroid adeoma

20
Q

may resemble normal thyroid tissue but shosw invasion

A

thyroid carcinoma well-diff.

21
Q

poor resemblance to normal thyroid, few follicles scant colloid has metastatic potential

A

poorly idfferentiated carcinoma of thyroid

22
Q

no resemblance to normal thyroid tissue high metastatic potential

A

anaplastic carcinoma of thyroid

23
Q

where is cellular atypia seen?

A

only in pre-malignant and malignant tumors

24
Q

key features of cellular atypia

A
  • cells and their nuclei vary in size and shape
  • dense and irregular nuclear outline
  • nucelar hyperchromicity
  • 1:1 nucelus/cytoplasm ratio
25
Q

abundant dna, extremel dark staining

A

hyperchromasia

26
Q

variation in size and shape of cells and nuclei

A

pleomorphism

27
Q

tumor giant cells represent

A

anaplasia

nuceli are hyperchromatic and large

28
Q

more anormal the mitoses, the more

A

likely the neoplasm is malignant

29
Q

hyperplasia of activated fibroblasts

A

desmomplasia

30
Q

imporant factors in tumor angiogenesis

A

VEGF

FGF

31
Q

pro-angiogenic factors

A

VEGF
bFGF
HIF

32
Q

anti-angiogenic factors

A

thrombospondin-1
angiostatin
endostatin
turnstatin

33
Q

why do malignant tumors show central necrosis?

A

tumor outgrows its blood supply and areas of ischemic necrosis appear

Pathology II (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions