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Pathology Exam II > Neoplasia IV > Flashcards

Neoplasia IV Flashcards

1
Q

dysplasia

A

disordered growth

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2
Q

how is grade of CIN defined

A

proportion of epithelium occupied by immature cells

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3
Q

carcinoma in situ

A

tull thickness dysplasi extending from BM to surface of epithelium

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4
Q

what can oral leukoplakia lead to

A

squamous cell carcinoma

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5
Q

what can barrett esophagus lead to

A

adenocarcinoma of esophagus

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6
Q

what can chronic atrophic gastritis of percincious anemia lead to

A

gastric adenocarcinoma

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7
Q

what can chronic ulcerative colitis lead to

A

adenocarcinoma of colon

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8
Q

what can hepatitis lead to

A

macronodular cirrhosis

hepatocellular carcinoma

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9
Q

what can simple/complex hyperplasia of endometrium lead to

A

atypical hyeprplain

endometrial adenocarcioma

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10
Q

what can solar keratosis of skin lead to

A

squamous cell carcinoma of skin

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11
Q

what are essetnial alterations for maligant transformation

A 
self-sufficeny in growth signals
insenstitiy to growth inhibitory signals
evasion of apoptosis
limitless replicative potential
sustained angiogenesis
ability to metastasize
defect in DNA repair
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12
Q

4 classes of normal regulatory genes

A

proto-oncogenes
tumor suppresor genes
genes regulating apoptosis
genes regulating DNA repair

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13
Q

proto-oncogene

A

responsible for regulation of growth and differentiation

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14
Q

what are activation mechanisms for proto onocogenes

A

point mutation
chromosomal translocation
amplification

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15
Q

HER2/Neu is a result of

A

amplification

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16
Q

RET is a result of

A

point mutation

17
Q

what does RET cause

A

MEN 2A and 2B

familial medullary thryoid carcinomas

18
Q

KRAS is a result of

A

point mutation

19
Q

KRAS results in

A

pancreas, colon, and lung cancers

20
Q

ABL is the result of

A

translocation

21
Q

what does ABL cause

A

chronic myeloid leuikemia

acute limp bizkuit

22
Q

what causes c-myc

A

translocation

23
Q

what does c-myc cause

A

burkitt lymphoma

24
Q

what causes n-myc

A

amplification

25
Q

what does n0myc cause

A

neuroblastoma

small cell CA of lung

26
Q

what casues cyclin D

A

translocation or amplication

27
Q

traslocation of cyclin D causes

A

mantle cell lymphoma

28
Q

amplification of cycline D causes

A

breast and esophageal cancers

29
Q

what happens when you have over-expression of bcl2

A

evade apoptosis

30
Q

what is the most common lyphoma

A

follicular

31
Q

what translation takes place in follicular lymphoma

A

14-`18

32
Q

what is the pathogenesis of collicular lymphoma

A

evasion of apoptosis

33
Q

what is the translocation of burkitt’s lymphoma

A

8-14

34
Q

what is the translocatino of chronic myelogenous leukema

A

9-22

Pathology Exam II (11 decks)

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