Neoplasia IV Flashcards
dysplasia
disordered growth
how is grade of CIN defined
proportion of epithelium occupied by immature cells
carcinoma in situ
tull thickness dysplasi extending from BM to surface of epithelium
what can oral leukoplakia lead to
squamous cell carcinoma
what can barrett esophagus lead to
adenocarcinoma of esophagus
what can chronic atrophic gastritis of percincious anemia lead to
gastric adenocarcinoma
what can chronic ulcerative colitis lead to
adenocarcinoma of colon
what can hepatitis lead to
macronodular cirrhosis
hepatocellular carcinoma
what can simple/complex hyperplasia of endometrium lead to
atypical hyeprplain
endometrial adenocarcioma
what can solar keratosis of skin lead to
squamous cell carcinoma of skin
what are essetnial alterations for maligant transformation
self-sufficeny in growth signals insenstitiy to growth inhibitory signals evasion of apoptosis limitless replicative potential sustained angiogenesis ability to metastasize defect in DNA repair
4 classes of normal regulatory genes
proto-oncogenes
tumor suppresor genes
genes regulating apoptosis
genes regulating DNA repair
proto-oncogene
responsible for regulation of growth and differentiation
what are activation mechanisms for proto onocogenes
point mutation
chromosomal translocation
amplification
HER2/Neu is a result of
amplification
RET is a result of
point mutation
what does RET cause
MEN 2A and 2B
familial medullary thryoid carcinomas
KRAS is a result of
point mutation
KRAS results in
pancreas, colon, and lung cancers
ABL is the result of
translocation
what does ABL cause
chronic myeloid leuikemia
acute limp bizkuit
what causes c-myc
translocation
what does c-myc cause
burkitt lymphoma
what causes n-myc
amplification
