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Pathology Exam II > Neoplasia VI > Flashcards

Neoplasia VI Flashcards

1
Q

what is ,elanoma associated with

A

EV radation

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2
Q

xeroderma pigmentosum

A

pre-cancerous

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3
Q

inonization radation has what kind of effect

A

direct or indirected via free radicals

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4
Q

most common mecnaism of ionizating radition

A

chromosome breakage

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5
Q

what cancers does atomic bomb cause

A

leukemias
thyorid
NOT skin

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6
Q

what cancers are common in x ray workers

A

radiation dermatitis

skin cancers

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7
Q

osteosarcoma is associated with what

A

painting dials of watches with luminous radium

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8
Q

pathogenesis of hepatitis B

A

chronic liver cell injury and regenerative hyperplasia

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9
Q

associated neoplasms for epstein-barr virus

A

burkitt lymphoma
hodgkin lymphoma
b cell lymphoma in immuno suppressed patients
nasopharyngeal carcinoma

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10
Q

high risk subtypes for HPVq

A
    1. 31
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11
Q

E6 inhibits

A

p53

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12
Q

E7 inhibits

A

RB

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13
Q

low risk subtypes of HPV

A

6 and 11

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14
Q

mode of transmission of human t cell leukemia type 1

A

sex, blood, breast feeding

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15
Q

pathogensis of HTLV-1

A

stimulate transcripton of viral mRNA
activates c-fos, IL2, GM-CSF,
inactives p16INK4a

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16
Q

HHV-8

A

kaposi sarcoma

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17
Q

tumors assocaited with helicobacter pylori

A

MALT

gastric carcinoma

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18
Q

genes assocaited with helicoacter pylori

A

CagA

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19
Q

what does CagA do

A

stimulates growth factor pathway

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20
Q

what cancers does estrogen promote

A

breast
quamous cell carcinoma of cervix
leiomyoma of uterus

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21
Q

what cancers do contraceptive hormones cause

A

breast

benign/malignant liver tumors

22
Q

what cancers do anabolic steroids cause

A

benign/maligant liver tumors

23
Q

cancer cachexia

A

loss of body fat, wasting, profound weakness

24
Q

what is the cause of cancer cachexia

A

TNF

25
Q

para-neoplastic syndromes

A

distant effects of a tumor unreleated to primary tumor metastasis

26
Q

endocrinopathies is assocaited with

A

lung cancer, ACTH- sushing syndrome

27
Q

hyponatremia/SIADH is associated with

A

small cell carcinoma secreting ADH

28
Q

acanthosis nigricans

A

pigmented skin lesion - black

29
Q

leser-trelat sign

A

multiple, outcroppings of pigmented seborrheic keratosis

30
Q

what is acanthosis nigricans and leser trelat sign assocaited with

A

stomach carcinoma

31
Q

carcinoid syndrome

A

producing serotine

32
Q

clinical features of carcnoid syndrome

A

flushing, diarrhea, bonrchospasm, tachycardia

33
Q

important para-neoplastic syndrome

A

hypercalcemia

34
Q

what causes hypercalcemia in malignancy

A

release of PTH related peptide

35
Q

what is release of PTH related peptide associated with

A

squamou cell Ca of lung

36
Q

what is hypocalcemia associated with

A

medullary CA of thyorid

37
Q

what hormonce causes hypoclaemia

A

calcitonin

38
Q

what hormone calses gyneocomastia

A

beta-HCG

39
Q

what cancer is asociated with gyneomastia

A

chorioCA testis

40
Q

what is eaton-lamber syndrome

A

myasthenia gravis-like syndrome

41
Q

what is eaton-lambert syndrome associated with

A

small cell CA of lung

42
Q

when do you us IHC

A

when you doon’t know cell of origin of tumor

43
Q

what does postiive cytokeratin mean

A

epithelial origin

44
Q

CD10 (CALLA) is assocaited with

A

acute limb biskuit

45
Q

what is placental alkaline phosphatase associated with

A

seminoma

46
Q

what is vWF, CD31 assoicated with

A

vascular neoplasms

47
Q

tumor marker

A

substance found in blood, urine, or body tissues that is elevated in cancer

48
Q

CEA is associated with

A

CA colon,
pancrease
stomach
breast

49
Q

CA-125 is assocaited with

A

ovarian carcinoma

50
Q

AFP is associated with

A

hepatocellualr carcinomas

germ cell tumors of testes or ovary

Pathology Exam II (11 decks)

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