Neoplasia VI

Question 1

what is ,elanoma associated with

Answer 1

EV radation

Question 2

xeroderma pigmentosum

Answer 2

pre-cancerous

Question 3

inonization radation has what kind of effect

Answer 3

direct or indirected via free radicals

Question 4

most common mecnaism of ionizating radition

Answer 4

chromosome breakage

Question 5

what cancers does atomic bomb cause

Answer 5

leukemias
thyorid
NOT skin

Question 6

what cancers are common in x ray workers

Answer 6

radiation dermatitis

skin cancers

Question 7

osteosarcoma is associated with what

Answer 7

painting dials of watches with luminous radium

Question 8

pathogenesis of hepatitis B

Answer 8

chronic liver cell injury and regenerative hyperplasia

Question 9

associated neoplasms for epstein-barr virus

Answer 9

burkitt lymphoma
hodgkin lymphoma
b cell lymphoma in immuno suppressed patients
nasopharyngeal carcinoma

Question 10

high risk subtypes for HPVq

Answer 10

16. 18. 31

Question 11

E6 inhibits

Answer 11

p53

Question 12

E7 inhibits

Answer 12

RB

Question 13

low risk subtypes of HPV

Answer 13

6 and 11

Question 14

mode of transmission of human t cell leukemia type 1

Answer 14

sex, blood, breast feeding

Question 15

pathogensis of HTLV-1

Answer 15

stimulate transcripton of viral mRNA
activates c-fos, IL2, GM-CSF,
inactives p16INK4a

Question 16

HHV-8

Answer 16

kaposi sarcoma

Question 17

tumors assocaited with helicobacter pylori

Answer 17

MALT

gastric carcinoma

Question 18

genes assocaited with helicoacter pylori

Answer 18

CagA

Question 19

what does CagA do

Answer 19

stimulates growth factor pathway

Question 20

what cancers does estrogen promote

Answer 20

breast
quamous cell carcinoma of cervix
leiomyoma of uterus

Question 21

what cancers do contraceptive hormones cause

Answer 21

breast

benign/malignant liver tumors

Question 22

what cancers do anabolic steroids cause

Answer 22

benign/maligant liver tumors

Question 23

cancer cachexia

Answer 23

loss of body fat, wasting, profound weakness

Question 24

what is the cause of cancer cachexia

Answer 24

TNF

Question 25

para-neoplastic syndromes

Answer 25

distant effects of a tumor unreleated to primary tumor metastasis

Question 26

endocrinopathies is assocaited with

Answer 26

lung cancer, ACTH- sushing syndrome

Question 27

hyponatremia/SIADH is associated with

Answer 27

small cell carcinoma secreting ADH

Question 28

acanthosis nigricans

Answer 28

pigmented skin lesion - black

Question 29

leser-trelat sign

Answer 29

multiple, outcroppings of pigmented seborrheic keratosis

Question 30

what is acanthosis nigricans and leser trelat sign assocaited with

Answer 30

stomach carcinoma

Question 31

carcinoid syndrome

Answer 31

producing serotine

Question 32

clinical features of carcnoid syndrome

Answer 32

flushing, diarrhea, bonrchospasm, tachycardia

Question 33

important para-neoplastic syndrome

Answer 33

hypercalcemia

Question 34

what causes hypercalcemia in malignancy

Answer 34

release of PTH related peptide

Question 35

what is release of PTH related peptide associated with

Answer 35

squamou cell Ca of lung

Question 36

what is hypocalcemia associated with

Answer 36

medullary CA of thyorid

Question 37

what hormonce causes hypoclaemia

Answer 37

calcitonin

Question 38

what hormone calses gyneocomastia

Answer 38

beta-HCG

Question 39

what cancer is asociated with gyneomastia

Answer 39

chorioCA testis

Question 40

what is eaton-lamber syndrome

Answer 40

myasthenia gravis-like syndrome

Question 41

what is eaton-lambert syndrome associated with

Answer 41

small cell CA of lung

Question 42

when do you us IHC

Answer 42

when you doon't know cell of origin of tumor

Question 43

what does postiive cytokeratin mean

Answer 43

epithelial origin

Question 44

CD10 (CALLA) is assocaited with

Answer 44

acute limb biskuit

Question 45

what is placental alkaline phosphatase associated with

Answer 45

seminoma

Question 46

what is vWF, CD31 assoicated with

Answer 46

vascular neoplasms

Question 47

tumor marker

Answer 47

substance found in blood, urine, or body tissues that is elevated in cancer

Question 48

CEA is associated with

Answer 48

CA colon, pancrease stomach breast

Question 49

CA-125 is assocaited with

Answer 49

ovarian carcinoma

Question 50

AFP is associated with

Answer 50

hepatocellualr carcinomas | germ cell tumors of testes or ovary