Neoplasia III

Question 1

e-cadherin

Answer 1

very important in detachment of tumor cells from each other

Question 2

laminin/laminin receptor

Answer 2

very important in tumor attachment to matrix component

Question 3

how does degradation of ECM happen

Answer 3

tumor cells release collagenases to degrade type IV basal membrane collegan

Question 4

how does migration of tumor cells happen

Answer 4

binding of fibronetin/it’s receptor

tumor cell secretes motility factor

Question 5

metastatic cascade

Answer 5

invasion of basement membrane
movement through ECM
vascular disseminiation
homing

Question 6

CD44

Answer 6

favors metastasis

Question 7

routes of metastasis

Answer 7

seeding of body cavities
lymphatic spread
hematogenous spread

Question 8

seeding of sub-arachnoid space

Answer 8

glioma

GBM

Question 9

what is the most common type of metastasis

Answer 9

lymphatic spread

Question 10

is lymphatic spread more typical of carcinoma or sarcoma

Answer 10

carcinoma

Question 11

what carcinomas do NOT have lymphatic spread

Answer 11

follicular carcinoma
renal cell carcinoma
hepatocellular carcinoma

Question 12

how do follicular carcinomas spread

Answer 12

local invasion

Question 13

how do renal cell carcinomas spread

Answer 13

into renal vein

Question 14

how do hepatocellular carcinomas spread

Answer 14

hematogenous

Question 15

what is hematogenous spread typical of

Answer 15

sarcomas

Question 16

does hematogenous spread normally go through veins or arteries

Answer 16

veins

Question 17

what are typical sites of hematogenous spread

Answer 17

liver
lungs
brains

Question 18

sentinel lymph node

Answer 18

1st node that recieves lymph from primary tumor

Question 19

how do you detect sentinel lymph node

Answer 19

radio labels tracers or blue dye

Question 20

what is the most common site for bony metastasis

Answer 20

vertebral column

Question 21

what are the two typies of bone metastasis

Answer 21

osteoblastic

osteolytic

Question 22

what does osteoblastic metastasis look like on an xray

Answer 22

radio dense loci

Question 23

what lab test is indicative of reactive bone formation

Answer 23

increased serum alk phosphatase

Question 24

what is the most common type o fosteoblastic metastatis

Answer 24

prostate cancer

Question 25

what does osteolytic metastasis look like on xray

Answer 25

lucencies in bone

Question 26

common metastatic site for stomach adenomacarcinoma

Answer 26

virchow’s left supraclacicular node

Question 27

what is the more important parameter - stage or grade

Answer 27

stage

Question 28

how can you find the grade of a tumor

Answer 28

degree of differentiation
mitotic index
uptake of BrdU by tumor cells

Question 29

TNM system of staging

Answer 29

size of primary tumor
nodal involvement
distant metastases

Question 30

most common tumors for men

Answer 30

prostate
lung
colorectal

Question 31

most common tumors for women

Answer 31

breast
lung
colon
rectum

Question 32

common nickle related cancer

Answer 32

nose lung

Question 33

radon cancer

Answer 33

lung

Question 34

vinyl chloride cancer

Answer 34

angiosarcoma of liver

Question 35

bladder cancer associated with

Answer 35

aniline dyes, textile, or rubber

Question 36

mesothelioma is associated with

Answer 36

abestos - pipe fitters, ship builders

Question 37

common tumors of infancy and childhood

Answer 37

blastomas
acute leukemia
rhabdomyosarcoma