Neoplasia

Question 1

What are the 2 components of a tumor?

Answer 1

1. Parenchyma

2. Supportive stroma: Reactive connective tissue and acellular components

Question 2

What are the 3 tumor characteristics?

Answer 2

1. Differentiation and anaplasia
2. Local invasion
3. Distant metastases

Question 3

Define differentiation and anaplasia

Answer 3

Differentiation: The extent to which neoplastic cells resemble normal cells
Anaplasia: A lack of differentiation

Question 4

Distinguish benign tumors from malignant tumors

Answer 4

Benign tumors are well differentiated. Malignant tumors range from well differentiated to undifferentiated.

Question 5

What are the morphologic marks of anaplasia?

Answer 5

1. Pleomorphism
2. Abnormal nuclear morphology
3. Abundant mitoses
4. Loss of polarity

Question 6

Discuss Metaplasia

Answer 6

Replacement of one type of cell with another. Almost always found in association with tissue damage and repair

Question 7

Describe Dysplasia

Answer 7

1. Loss in uniformity
2. Loss of orientation
3. Pleomorphism
4. Hyperchromatic, Large nuclei

Question 8

Discuss Local Invasion

Answer 8

Benign tumors expand locally and form a capsule consisting of CT around the tumor.