Inflammation 3 Flashcards
Describe a serous exudate.
An outpouring of watery low protein fluid from blood serum or secretions of mesothelial cells; Yellow or clear
Describe a fibrinous exudate
Contains large amounts of fibrin; Eosinophile, thin and linear
How is a fibronous exudate formed?
Soluble fibrinogen leaks out of the plasma and polymerizes into insoluble fibrin within tissues.
What is the role of fibronous exudate?
Blood clotting, chemotatic for neutrophils, Wall of area of irritation
What is a suppurative/purulent exudate?
Rich in neutrophils and necrotic cells. Often accompanied by liquefactive necrosis; Forms in response to pyogenic infection.
What are the 3 types of suppurative exudate?
- Abscesses: pus walled off by CT.
- Pyemia: Hyperemia surrounded by fibroblast proliferation around abscesed region.
- Empyema: Accumulation of pus in a hollow viscus
Describe granulomatous inflammation
Macrophages and lymphocytes cluster around the offending agent; Always chronic inflammation
Define chronic inflammation
Prolonged inflammation; weeks to months
What are some causes of chronic inflammation?
Persistent infection, Microbes that are difficult to kill, prolonged exposure
Differentiate Non-suppurative from granulomatous
Non-suppurative: An even mixture of mononuclear cells.
Granulomatous: when macrophages dominate, sign of repair by angiogenesis and fibrosis
Differentiate chronic vs acute inflammation in the lung.
Chronic: Parenchymal destruction, fibrotic replacement of CT
Acute: Cellular infiltrate composed of neutrophils, no fibrosis
What are the pyrogenic cytokines?
IL-1, TNF, IFN, and IL-6
What are the systemic clinical aspects of inflammation?
- Reactive Hyperplasia
- Negative Nitrogen Balance
- Pain
- Erythrocte sedimentation rate
- Coagulability
- Leukocytosis
- Acute phase proteins
