Neoplasia 3: Chemical Carcinogenicity Tests and Other Chemical Carcinogens

Question 1

Mutagens

Answer 1

Substances that can PERMANENTLY alter genetic composition

Mutagenicity in vitro correlates well with carcinogenicity in vivo

Question 2

Tests for mutagenicity

Answer 2

Ames Test

Question 3

Ames Test

Answer 3

Detects ability of a chemical to INDUCE MUTATION in a MUTANT STRAIN OF Salmonella Typhimurium

So, if the mutagen substance gives mutations in salmonella, it means that it’s a real carcinogen and can lead to malignancies

Question 4

Naturally Occurring Carcinogen

Answer 4

Aspergillus Flavus GIVES chemical toxin: Aflatoxin Beta 1

which can lead to hepatocellular carcinoma

Question 5

Nitrosamines and Amides

Answer 5

Gastric carcinomas

Question 6

Asbestos

Answer 6

Bronchogenic carcinomas
Mesotheliomas
GIT cancers