Neoplasia 1: Inherited Cancer Syndromes: Autosomal Dominant, Autosomal Recessive (AR), and Familial

Question 1

Rb gene

Answer 1

Retinoblastoma

Question 2

p53

Answer 2

Li-Fraumeni syndrome (various tumors) - elderly

Question 3

p16/INK4A

Answer 3

Melanoma

Question 4

APC

Answer 4

Familial adenomatous polyposis/colon cancer (By second decade)

Question 5

BRCA1, BRCA2

Answer 5

Breast and ovarian tumors

Question 6

MEN 1, RET

Answer 6

Multiple Endocrine Neoplasia 1 and 2

Question 7

MSH2, MLH1, MSH6

Answer 7

Hereditary Nonpolyposis Colon Cancer (HNPCC)

Question 8

PTCH

Answer 8

Nevoid Basal Cell Carcinoma Syndrome

Question 9

PTEN

Answer 9

Cowden Syndrome (epithelial cancers)

Question 10

LKB1

Answer 10

Peutz-Jegher Syndrome (epithelial cancers)

Hamartoma!

Question 11

VHL

Answer 11

Renal Cell Carcinomas

Question 12

ATM, ATR gene

Answer 12

Ataxia Telangiectasia (AR)

Question 13

Bloom’s Syndrome (AR)

Answer 13

Lymphoma and Leukemia

Question 14

Fanconi’s Anemia (AR)

Answer 14

Lymphoma and leukemia

Question 15

Xeroderma Pigmentosum (AR)

Answer 15

Skin cancers

Question 16

Ataxia Telangiectasia (AR)

Answer 16

Lymphoma, leukemia, and breast cancers

Question 17

Familial cancers

Answer 17

Colon, breast, and pancreas

Question 18

NF1, NF2

Answer 18

Neurofibromatosis 1 and 2