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M3 Path B1 > Neoplasia 2: Chromosomal Translocations Oncogenes (Dysregulation of Cancer Associated Genes) > Flashcards

Neoplasia 2: Chromosomal Translocations Oncogenes (Dysregulation of Cancer Associated Genes) Flashcards

1
Q

CML

A

Abl proto-oncogene
9 and 22
Philadelphia chromosome

Splenomegaly, increased platelets, increased myeloids (PMNs, myelocyes, and basophils)

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2
Q

AML

A

AML gene

8,21

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3
Q

AML with cytogenetic abnormalities

A

15,17 –> promyelocytic leukemia

PML Gene

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4
Q

Burkitt Lymphoma

A

8,14

C-MYC gene

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5
Q

Mantle Cell Lymphoma

A

11,14
Bcl-1

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6
Q

Follicular Lymphoma

A

14,18

BCL2

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7
Q

Ewing Sarcoma

A

11,22

Diaphysis

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M3 Path B1 (29 decks)

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