Neoplasia 2: Invasion of ECM Steps

Question 1

1

Answer 1

Detachment “loosening up” of tumor cells from each other via down regulations of cadherins (adhesion molecules)

Question 2

2

Answer 2

Attachment to matrix components: to laminin and fibronectin via cell surface receptors

Question 3

3

Answer 3

Degradation of ECM: proteolytic enzymes (Type IV collagenases, cathepsin D, urokinase type plasminogen activator)

Question 4

4

Answer 4

Migration of tumor cells: poorly understood (autocrine motility factors)