Neisseria gonorrhoeae

Question 1

Neisseria gonorrhoeae is?

Answer 1

Is sexually transmitted

Question 2

Is Neisseria gonorrhoeae gram postive or negative?

Answer 2

Gram negative diplococci

Question 3

Culture for Neisseria gonorrhoeae?

Answer 3

2. culture (urethral pus; Thayer-martin VCN)
   a. WBCs
   b. high CO2 enviorment

Question 4

Neisseria gonorrhoeae does what?

Answer 4

ferments glucose

Question 5

Is Neisseria gonorrhoeae obligate aerobe or Facultative anaerobe?

Answer 5

Facultative anaerobe

Question 6

What are the virulence factors Neisseria gonorrhoeae involving pili?

Answer 6

a. adherence
b. antigenic variation
c. antiphagocytic: binds bacteria tightly to host cell

Question 7

What are the virulence factors Neisseria gonorrhoeae involving outer membrane proteins?

Answer 7

a. Protein I: porin

b. Protein II: (opacity protein): presence associated w/dark, opaque colonies for adherence

Question 8

What are the clinical manifestations for Neisseria gonorrhoeae?

Answer 8

1. endotoxin: LPS

Question 9

What are the clinical manifestations for Neisseria gonorrhoeae?

Answer 9

1. endotoxin: LPS
   a. men: urethritis
   b. women: cervical gonorrhea > PID (ascending)
   cx: sterility, ectopic pregnancies, abcesses, peritonitis, perihepatitis, salpingitis
   c. men and women: gonococcal bacteremia, septic arthritis
   d. neonates: opthalia neonatorum conjuctivitis (usu erupts in first 5 days)

Question 10

Treatment for Neisseria gonorrhoeae?

Answer 10

1. 1st line
   a. 3rd gen C’sporins (ceftriaxone)+ doxycycline for chlamydia and syphilis
2. 2nd line ( not efective for syphilis)
   a. fluoroquinolones
   b. spectinomycin
3. opthalmia neonatorum
   a. erythromycin eye drops prophylaxis
   b. w/disease: ceftriaxone + erythromycin serum for chlamydia