Chlamydia trachomatis

Question 1

Where is Chlamydia trachomatis found? how is it contacted?

Answer 1

• humans

- direct contact

Question 2

Is Chlamydia trachomatis gram positve or negative?

Answer 2

• Gram negative

- lack peptidoglycan layer

Question 3

what are thr virulence factors for Chlamydia trachomatis?

Answer 3

1. resistant to lysozyme
2. prevents phagosome-lysosome
   fusion
3. nonmotile
4. no pili
5. no exotoxins
   Cell Cycle:
6. elementary body infects cells >
   reticulate body that replicates (req’
   host ATP > elementary body that
   leaves cell and infects other cells
7. tropism for endothelial columnar
   cells

Question 4

What are the clinical manifestattion of Chlamydia trachomatis?

Answer 4

1. serotypes A, B, C:
   a. trachoma: scarring of inside of eyelidÆ
   redirection of eyelashes onto corneal
   surface (corneal scarring and blindness)
2. serotypes D-K:
   a. inclusion conjunctivitis (opthalmia
   neonatorum)
   b. infant pneumonia
   c. urethritis, cervicitis, PID in women
   d. nongonoccal urethritis, epididymitis,
   prostatitis in men
   cx: sterility, ectopic pregnancy, chronic pain,
   reiter’s syndrome, perihepatitis (Fitz-Hugh-
   Curtis Syndrome)
3. serotypes L (1-3):
   a. lymphogranuloma venereum

Question 5

What are the treatments for