Clostridium difficile

Question 1

Where is Clostridium difficle found?

Answer 1

• Gi tract
• hospitals
• nursinf homes

Question 2

Is Clostridium difficle gram positive or negative?

Answer 2

Gram postive spore forming rods

Question 3

What is the virulence factor for Clostridium difficle?

Answer 3

flagella (H-Ag(+))

Question 4

What are the clinical manifestations for Clostridium difficle?

Answer 4

1) Toxin a
- diarrhea
2) toxin B
- cytotoxic to colonic epithelial cells

> pseudomembranous enterocolitis (antibiotic- associated diarrhea)

Question 5

What is the Treatment for Clostridium difficle

Answer 5

1. Metronidazole
2. oral vancomycin
3. terminate use of responsible antibiotic