Neisseria Flashcards
mention the pathogenic and comensal of Neisseria
P:
N. gonorrhoea
N. meningitidis.
C: N. sicca N. mucosa N. flavescens N. lactamica M. catarrhalis
some cats favore milk
Mention some charachterstics of pathogenic N
gram negative diplococci
all N are aerobics, thay have cytochrome c
require enriched media as heated blood 80 choclate agar, or selective media MTM media
rapidly killed by dryness, sun light, moist, heat, disinfectants.
what’s the special characters about N endotoxins?
it’s lipooligosaccharide similar to rods
lack O antigen
compare between N. gonorrhoea and meningitidis from; 1_site 2_clinical presentation 3_polysaccharide capsule 4_plasmid 5_sugar fermentation 6_vaccine
G. M URT. Genital T meningitis. gonorrhoea present. absent absent. present. glucose and maltose. glucose only. available. no.
compare characters of N. meningitidis, N. lactamica?
1_N. lactamica ferment lactose
2_it gives yellow colonies on selective media, while meningitidis is non pigmented
Mention the common cause for menegitis in new born to 2 months.
S. agalacti, S. pneumonia, L. monocytogenes, E. coli
Mention the common cause for menegitis in babies and children.
S pneumonia, N. menengtidis, H. influenza b, S. agalacti.
Mention the common cause for menegitis in teens and young adults.
N. meng., S. pneumonia
Mention the common cause of meningitis in older adults.
S. pneumonia, N. meningitidis, Hi b, S. agalacti, L. monocytogenes.
what’s the special characters about N. go, N. men ifection?
they are pure human disease.
what’s the most common cause for menegitis epidemics?
N. menengtidis.
Mention the classification of N. menengtidis according to hetrogenecty.
1_13 serogroup based on capsular polysaccharide.
2_5 serotype based on mem.protein
3_immunotype according to lipooligosaccharide
what’s the most important serogroups for N. menengtidis?
A, C, Y, W135
What’s the function of different OMP of N. meningitidis?
1_class1,2,3 analog for por pn,promot intracellular survival.
2_class4 analog to RMP,protet other surfaceantigens from bactericidal ABa.
3_class5 analog to opa pn,play role in attachment to host cell.
Mention the virulance factors of N. meningitidis.
1_polysaccharide capsule. 2_pili 3_OMP 4_IgA protease 5_lipooligosaccharide
give the names of some diseasea caused by N. meningitidis.
1_meningitis
2_meningococcemia «waterhouse_friderichsen syndrome.
3_Pneumonia.
4_Arthritis
what’s waterhouse friderichsen syndrom and give some charachterstics of it.
most severe form of meningococcemia. charachtrized by: 1_high fever 2_shock 3_widespread purpura 4_Disseminated intravascular coagulation 5_Adrenal insufficiency
what’s the most common compilication of meningococcemia? How does it begins?
meningitis.
begins with: sever headache,fever,vomiting,nuchal rigidity,rigidity of back muscles.
kernigs and Brudzinskis signs are present.
may progress to coma.
what’s the speicmens taken for the diagnosis of N. meningitidis?
CSF, blood, puncture from joints fluid or petechiae.
Nasopharynx swap.
what’s the tests available for the diagnosis of N. meningitidis?
A_specimen: Phisical test chemical test bacteriological examination 1_coaggulutination test or quelling test 2_latex aggultination latex 3_presence of intracellular&extracellular gram negative diplococci 4_culture on chocolate agar(colonial morphology,biochemical tests).
B_blood culture
C_pcr
D_serology «aggultination latex or hemagglutination T».
what’s the proper treatment and prophylaxis for N. meningitidis?
combination of I. V antibiotics;
Ampicillin+third generation cephalosporin
(cefotaxime or ceftriaxone).
chemoprophylaxis:
Rifampicin for carriers
ciprofloxacin for contacts
mention the two available vaccines for N. meningitidis.
their function?
Which is better?
1_MPSV4
2_MCV4
They are protective, reduce the carrier rate, effective in preventing epidemics.
MCV4 gives better, longer lasting protection.
