Neisseria

Question 1

mention the pathogenic and comensal of Neisseria

Answer 1

P:
N. gonorrhoea
N. meningitidis.

C: 
N. sicca
N. mucosa
N. flavescens
N. lactamica
M. catarrhalis

some cats favore milk

Question 2

Mention some charachterstics of pathogenic N

Answer 2

gram negative diplococci
all N are aerobics, thay have cytochrome c
require enriched media as heated blood 80 choclate agar, or selective media MTM media
rapidly killed by dryness, sun light, moist, heat, disinfectants.

Question 3

what’s the special characters about N endotoxins?

Answer 3

it’s lipooligosaccharide similar to rods

lack O antigen

Question 4

compare between N. gonorrhoea and meningitidis from;
1_site
2_clinical presentation
3_polysaccharide capsule
4_plasmid
5_sugar fermentation
6_vaccine

Answer 4

G.                  M
URT.         Genital T
meningitis.      gonorrhoea 
present.           absent
absent.           present. 
glucose and maltose.         glucose only. 
available.             no.

Question 5

compare characters of N. meningitidis, N. lactamica?

Answer 5

1_N. lactamica ferment lactose

2_it gives yellow colonies on selective media, while meningitidis is non pigmented

Question 6

Mention the common cause for menegitis in new born to 2 months.

Answer 6

S. agalacti, S. pneumonia, L. monocytogenes, E. coli

Question 7

Mention the common cause for menegitis in babies and children.

Answer 7

S pneumonia, N. menengtidis, H. influenza b, S. agalacti.

Question 8

Mention the common cause for menegitis in teens and young adults.

Answer 8

N. meng., S. pneumonia

Question 9

Mention the common cause of meningitis in older adults.

Answer 9

S. pneumonia, N. meningitidis, Hi b, S. agalacti, L. monocytogenes.

Question 10

what’s the special characters about N. go, N. men ifection?

Answer 10

they are pure human disease.

Question 11

what’s the most common cause for menegitis epidemics?

Answer 11

N. menengtidis.

Question 12

Mention the classification of N. menengtidis according to hetrogenecty.

Answer 12

1_13 serogroup based on capsular polysaccharide.
2_5 serotype based on mem.protein
3_immunotype according to lipooligosaccharide

Question 13

what’s the most important serogroups for N. menengtidis?

Answer 13

A, C, Y, W135

Question 14

What’s the function of different OMP of N. meningitidis?

Answer 14

1_class1,2,3 analog for por pn,promot intracellular survival.
2_class4 analog to RMP,protet other surfaceantigens from bactericidal ABa.
3_class5 analog to opa pn,play role in attachment to host cell.

Question 15

Mention the virulance factors of N. meningitidis.

Answer 15

1_polysaccharide capsule.
2_pili
3_OMP
4_IgA protease
5_lipooligosaccharide

Question 16

give the names of some diseasea caused by N. meningitidis.

Answer 16

1_meningitis
2_meningococcemia «waterhouse_friderichsen syndrome.
3_Pneumonia.
4_Arthritis

Question 17

what’s waterhouse friderichsen syndrom and give some charachterstics of it.

Answer 17

most severe form of meningococcemia. 
charachtrized by: 
1_high fever
2_shock
3_widespread purpura
4_Disseminated intravascular coagulation
5_Adrenal insufficiency

Question 18

what’s the most common compilication of meningococcemia? How does it begins?

Answer 18

meningitis.
begins with: sever headache,fever,vomiting,nuchal rigidity,rigidity of back muscles.
kernigs and Brudzinskis signs are present.
may progress to coma.

Question 19

what’s the speicmens taken for the diagnosis of N. meningitidis?

Answer 19

CSF, blood, puncture from joints fluid or petechiae.

Nasopharynx swap.

Question 20

what’s the tests available for the diagnosis of N. meningitidis?

Answer 20

A_specimen:
Phisical test 
chemical test 
bacteriological examination 
1_coaggulutination test or quelling test
2_latex aggultination latex
3_presence of intracellular&extracellular gram negative diplococci
4_culture on chocolate agar(colonial
 morphology,biochemical tests).

B_blood culture
C_pcr
D_serology «aggultination latex or hemagglutination T».

Question 21

what’s the proper treatment and prophylaxis for N. meningitidis?

Answer 21

combination of I. V antibiotics;
Ampicillin+third generation cephalosporin
(cefotaxime or ceftriaxone).

chemoprophylaxis:
Rifampicin for carriers
ciprofloxacin for contacts

Question 22

mention the two available vaccines for N. meningitidis.
their function?
Which is better?

Answer 22

1_MPSV4
2_MCV4
They are protective, reduce the carrier rate, effective in preventing epidemics.

MCV4 gives better, longer lasting protection.